Sperm Motility Loss Induced by Gossypol: Relation with OH. Scavengers, Motile Stimulators and Malondialdehyde Production Article

Fornes, MW, Barbieri, AM, Burgos, MH. (1993). Sperm Motility Loss Induced by Gossypol: Relation with OH. Scavengers, Motile Stimulators and Malondialdehyde Production . BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 195(3), 1289-1293. 10.1006/bbrc.1993.2183

cited authors

  • Fornes, MW; Barbieri, AM; Burgos, MH

authors

abstract

  • Aerobic incubation of rat spermatozoa in a balanced salt solution containing 10 μM of gossypol produced a loss of sperm motility. This effect was not reverted by the presence of 25 mM Teophylline, a well-known stimulant of motility, but was significantly diminished by the addition of 10 mM Mannitol. As mannitol is a superoxide scavenger and we found a close correlation between the loss of sperm motility and the malondialdehyde production, we concluded that gossypol affect rat spermatozoa by producing a peroxidative breakdown of membrane phospholipids. © 1993 Academic Press. All rights reserved.

publication date

  • September 30, 1993

published in

Digital Object Identifier (DOI)

start page

  • 1289

end page

  • 1293

volume

  • 195

issue

  • 3