A system for the intraoperative localization of the focus of epilepsy from array electrocorticography is presented. The spatio-temporal structure that characterizes the surface potential field during the occurrence of focal interictal events is discussed. The Spatio-Temporal Laplacian (STL) transformation is proposed for selectively emphasizing these occurrences. The implementation of the on-line localization system in a multi-processor platform is outlined and detailed results from three surgery cases are shown.