FIU Discovery

Mitochondrial hyperfusion induces metabolic remodeling in lung endothelial cells by modifying the activities of electron transport chain complexes I and III.  FREE RADICAL BIOLOGY AND MEDICINE.  210:183-194.

Simvastatin restores pulmonary endothelial function in the setting of pulmonary over-circulation.  NITRIC OXIDE-BIOLOGY AND CHEMISTRY.  142:58-68.

Novel Relationship between Mitofusin 2-Mediated Mitochondrial Hyperfusion, Metabolic Remodeling, and Glycolysis in Pulmonary Arterial Endothelial Cells

Endothelin-1 acutely increases nitric oxide production via the calcineurin mediated dephosphorylation of Caveolin-1.  NITRIC OXIDE-BIOLOGY AND CHEMISTRY.  140:50-57.

SOX17 Deficiency Mediates Pulmonary Hypertension At the Crossroads of Sex, Metabolism, and Genetics.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.  207:1055-1069.

Nitration-mediated activation of the small GTPase RhoA stimulates cellular glycolysis through enhanced mitochondrial fission

Abstract 13625: Autophagy Plays a Key Role in the Loss of Nitric Oxide Signaling and Endothelial Dysfunction in Pulmonary Vascular Diseases.  CIRCULATION.  146:a13625-a13625.

Abstract 14973: Upregulated Sphingosine-1-Phosphate Receptor 3 Disrupts Endothelial Cell Barrier and Mitochondrial Network Dynamics.  CIRCULATION.  146:a14973-a14973.

Arginine recycling in endothelial cells is regulated BY HSP90 and the ubiquitin proteasome system.  NITRIC OXIDE-BIOLOGY AND CHEMISTRY.  108:12-19.

The mitochondrial redistribution of eNOS is involved in lipopolysaccharide induced inflammasome activation during acute lung injury.  REDOX BIOLOGY.  41.

Activation of the mechanosensitive Ca2+ channel TRPV4 induces endothelial barrier permeability via the disruption of mitochondrial bioenergetics.  REDOX BIOLOGY.  38.

RAC1 nitration at Y-32 IS involved in the endothelial barrier disruption associated with lipopolysaccharide-mediated acute lung injury.  REDOX BIOLOGY.  38.

TGF-beta 1 attenuates mitochondrial bioenergetics in pulmonary arterial endothelial cells via the disruption of carnitine homeostasis.  REDOX BIOLOGY.  36.

Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  60:503-514.

LPS-induced Acute Lung Injury Involves NF-kappa B-mediated Downregulation of SOX18.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  58:614-624.

Endothelial HIF-2 alpha contributes to severe pulmonary hypertension due to endothelial-to-mesenchymal transition.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY.  314:L256-L275.

Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY.  312:1309-1325.

Hyper-activation of pp60(Src) limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.  FREE RADICAL BIOLOGY AND MEDICINE.  102:217-228.

Pulmonary artery smooth muscle cell hyperproliferation and metabolic shift triggered by pulmonary overcirculation.  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY.  311:H944-H957.

Asymmetric Dimethylarginine Stimulates Akt1 Phosphorylation via Heat Shock Protein 70-Facilitated Carboxyl-Terminal Modulator Protein Degradation in Pulmonary Arterial Endothelial Cells.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  55:275-287.

Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.  REDOX BIOLOGY.  6:278-286.

Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism.  REDOX BIOLOGY.  6:112-121.

313 Complex I Dysfunction Dictates Glycolytic Switch in Pulmonary Hypertensive Smooth Muscle Cells.  FREE RADICAL BIOLOGY AND MEDICINE.  87:s140.

Abstract 90: Akt Mediated Mitochondrial Dysfunction Involves Mitochondrial Endothelial Nitric Oxide Synthase Translocation.  CIRCULATION RESEARCH.  117.

Endothelin-1 Induces a Glycolytic Switch in Pulmonary Arterial Endothelial Cells via the Mitochondrial Translocation of Endothelial Nitric Oxide Synthase.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  50:1084-1095.

Ca2+/Calmodulin-Dependent Protein Kinase II Contributes to Hypoxic Ischemic Cell Death in Neonatal Hippocampal Slice Cultures.  PLOS ONE.  8.

L-Carnitine preserves endothelial function in a lamb model of increased pulmonary blood flow.  PEDIATRIC RESEARCH.  74:39-47.

Disruption of Endothelial Cell Mitochondrial Bioenergetics in Lambs with Increased Pulmonary Blood Flow.  ANTIOXIDANTS & REDOX SIGNALING.  18:1739-1752.

Asymmetric Dimethylarginine Induces Endothelial Nitric-oxide Synthase Mitochondrial Redistribution through the Nitration-mediated Activation of Akt1

Role of Carnitine Acetyl Transferase in Regulation of Nitric Oxide Signaling in Pulmonary Arterial Endothelial Cells.  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES.  14:255-272.

Groundwater Contaminated with Hexavalent Chromium [Cr (VI)]: A Health Survey and Clinical Examination of Community Inhabitants (Kanpur, India).  PLOS ONE.  7.

PPAR-gamma Regulates Carnitine Homeostasis and Mitochondrial Function in a Lamb Model of Increased Pulmonary Blood Flow.  PLOS ONE.  7.

Preserving mitochondrial function prevents the proteasomal degradation of GTP cyclohydrolase I.  FREE RADICAL BIOLOGY AND MEDICINE.  53:216-229.

C-Terminus of Heat Shock Protein 70-Interacting Protein-Dependent GTP Cyclohydrolase I Degradation in Lambs with Increased Pulmonary Blood Flow.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  45:163-171.

Estradiol Increases Guanosine 5 '-Triphosphate Cyclohydrolase Expression Via the Nitric Oxide-Mediated Activation of Cyclic Adenosine 5 '-Monophosphate Response Element Binding Protein.  ENDOCRINOLOGY.  150:3742-3752.

GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY.  297:L309-L317.

Hydrogen Peroxide Decreases Endothelial Nitric Oxide Synthase Promoter Activity through the Inhibition of Sp1 Activity

Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of AP-1 activity.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY.  295:L370-L377.

Sp1/AP2‐dependent regulation of the TATA‐less promoter of the CMP‐NeuAc:GM3 2,8 sialyltransferase (GD3‐synthase) gene.  FASEB JOURNAL.  22:782.3-782.3.

Down-regulation of WNK1 protein kinase in neural progenitor cells suppresses cell proliferation and migration.  JOURNAL OF NEUROCHEMISTRY.  99:1114-1121.

Critical role of Brg1 member of the SWI/SNF chromatin remodeling complex during neurogenesis and neural crest induction in zebrafish.  DEVELOPMENTAL DYNAMICS.  235:2722-2735.

Minor proteins and enzymes of the Drosophila eggshell matrix.  DEVELOPMENTAL BIOLOGY.  293:127-141.

The Mitochondrial Redistribution of eNOS is involved in Lipopolysaccharide Induced Inflammasome Activation During Acute Lung Injury.  FREE RADICAL BIOLOGY AND MEDICINE. S101-S101.

Cyclic stretch-induced eNOS translocation to the mitochondrion induces mitochondrial dysfunction and oxidative stress in pulmonary artery endothelial cells.  FREE RADICAL BIOLOGY AND MEDICINE. S45-S45.

Inhibition of PHD2 Induces Endothelial-to-Mesenchymal Transition in Pulmonary Vascular Endothelial Cells.  FASEB JOURNAL.

Hot, Heat and Stretch All Contribute to the Enhanced Ca2+ Signaling in Pulmonary Arterial Hypertension.  FASEB JOURNAL.

Asymmetric Dimethylarginine (ADMA) Mediated Activation Of Akt1 Signaling In Endothelial Cells.  a4824-a4824.

CHIP-dependent GTP cyclohydrolase I degradation underlies the decrease in tetrahydrobipterin levels in lambs with congenital heart disease and increased pulmonary blood flow: Role of asymmetric dimethyarginine.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Targeting the mitochondrial fission-mediator Drp1 is a potential therapeutic strategy for ventilator induced lung injury.  FREE RADICAL BIOLOGY AND MEDICINE. S94-S94.

Mitochondrial Hyperfusion Disrupts Carbohydrate Metabolism In Lung Endothelial Cells By Modifying The Activities Of Electron Transport Chain Complexes I And III.  FREE RADICAL BIOLOGY AND MEDICINE.

Mitochondrial redistribution of eNOS is regulated by CHIP mediated disruption of Dimerization.  FREE RADICAL BIOLOGY AND MEDICINE.

NAMPT induces Mitochondrial and Barrier Dysfunction in Pulmonary Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE.

The anti-apoptotic protein, Survivin induces a shift in endothelial cell in carbon metabolism through a mitochondrial-ROS-dependent increase in HIF-1a signaling.  FREE RADICAL BIOLOGY AND MEDICINE.

Autophagy plays a key role in hyper-proliferative phenotype in pulmonary vascular diseases.  FREE RADICAL BIOLOGY AND MEDICINE. 52-52.

Increased Mitochondrial Fission Induces a Warburg Phenotype Via the Hydrogen Peroxide Mediated inhibition of Prolyl Hydroxylase 2 (PHD2) in Pulmonary Arterial Endothelial Cells.  FREE RADICAL BIOLOGY AND MEDICINE. 100-100.

Mitochondrial Fission Drives A Glycolytic Endothelial Phenotype In Pulmonary Hypertension: Role Of Nitrated RhoA.  FREE RADICAL BIOLOGY AND MEDICINE. 49-49.

Role Of Mitochondrial ROS and HIF Signaling in the Metabolic Reprogramming Associated with Increased Sox18 Expression.  FREE RADICAL BIOLOGY AND MEDICINE. 56-57.

VILI Induced Nitration of RhoA Disrupts Mitochondrial Function Through Increased Generation of Reactive Oxygen Species.  FREE RADICAL BIOLOGY AND MEDICINE. 46-46.

Role of Carboxyl-Terminal Modulator Protein in the Nitration Mediated Activation of Akt1.  FREE RADICAL BIOLOGY AND MEDICINE. S166-S166.

Nitration Mediated Activation of Akt Involved in Endothelial Nitric Oxide Synthase (eNOS) Mitochondria Translocation.  FREE RADICAL BIOLOGY AND MEDICINE. S139-S139.