FIU Discovery

Regional alterations of parvalbumin interneurons in human App knock-in mouse model of Alzheimer's disease pathology.  Neurobiology of Aging.  166:41-49.

Bidirectional control of vesicular GABA release, LTP, and amotivation by GluN2D-selective allosteric modulators and ketamine.  Cell Reports.  45.

An Interactive Patch Clamping Simulation to Teach and Train Electrophysiology.  Biomedical Engineering Education.  6:57-65.

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes.  NEURON.  113:1525-1547.

Patch-walking, a coordinated multi-pipette patch clamp for efficiently finding synaptic connections.  eLife.  13.

Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology.  NATURE COMMUNICATIONS.  15.

Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer's pathology.  NATURE COMMUNICATIONS.  15.

An enhancer-AAV approach selectively targeting dentate granule cells of the mouse hippocampus.  CELL REPORTS METHODS.  4.

Streamlined Intravital Imaging Approach for Long-Term Monitoring of Epithelial Tissue Dynamics on an Inverted Confocal Microscope.  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 

Biophysical Kv channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s.  ALZHEIMERS & DEMENTIA.  18.

Cell-type specific alterations in intrinsic excitability and neurotransmission in short-term virally induced model of Alzheimer’s Disease.  ALZHEIMERS & DEMENTIA.  18.

Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons.  eLife.  11.

Biophysical K_v3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer's.  eLife.  11.

Cell type-specific biotin labeling in vivo resolves regional neuronal and astrocyte proteomic differences in mouse brain.  NATURE COMMUNICATIONS.  13.

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease..  Brain Neurosci Adv.  6:23982128221086464.

Mitochondrial Proteostasis Requires Genes Encoded in a Neurodevelopmental Syndrome Locus.  JOURNAL OF NEUROSCIENCE.  41:6596-6616.

Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling.  NATURE COMMUNICATIONS.  12.

Deep learning-based real-time detection of neurons in brain slices for in vitro physiology.  SCIENTIFIC REPORTS.  11.

Graded Control of Climbing-Fiber-Mediated Plasticity and Learning by Inhibition in the Cerebellum.  NEURON.  99:999-+.

Inhibition gates supralinear Ca²⁺ signaling in Purkinje cell dendrites during practiced movements.  eLife.  7.

Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice.  PLOS ONE.  12.

Rapid State-Dependent Alteration in Kv3 Channel Availability Drives Flexible Synaptic Signaling Dependent on Somatic Subthreshold Depolarization..  CELL REPORTS.  18:2018-2029.

Synapse-Level Determination of Action Potential Duration by K⁺ Channel Clustering in Axons.  NEURON.  91:370-383.

Distinct K_v Channel Subtypes Contribute to Differences in Spike Signaling Properties in the Axon Initial Segment and Presynaptic Boutons of Cerebellar Interneurons.  JOURNAL OF NEUROSCIENCE.  34:6611-6623.

Fast glutamate uptake via EAAT2 shapes the cone-mediated light offset response in bipolar cells.  JOURNAL OF PHYSIOLOGY-LONDON.  588:3943-3956.

Native-state and cell type-specific proteomics using TurboID proximity labeling in mouse models.  61-88.

Taurine Regulation of Voltage-Gated Channels in Retinal Neurons.  Advances in Experimental Medicine and Biology. 85-99.

Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology..  Res Sq.

Streamlined intravital imaging approach for long-term monitoring of epithelial tissue dynamics on an inverted confocal microscope..  bioRxiv.

An enhancer-AAV toolbox to target and manipulate distinct interneuron subtypes.

Regional susceptibility of PV interneurons in an hAPP-KI mouse model of Alzheimer's disease pathology.

Patch-walking: Coordinated multi-pipette patch clamp for efficiently finding synaptic connections.

Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology.

Native-state proteomics of Parvalbumin interneurons identifies novel molecular signatures and metabolic vulnerabilities to early Alzheimer's disease pathology.

A novel enhancer-AAV approach selectively targeting dentate granule cells.

A Novel Enhancer-AAV Approach Selectively Targeting Dentate Granule Cells

Biophysical Kv channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s

Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

Input-specific gating of NMDA amplification via HCN channels in mouse L2/3 pyramidal neurons

Patch-walking, a coordinated multi-pipette patch clamp for efficiently finding synaptic connections

Patch-walking: Coordinated multi-pipette patch clamp for efficiently finding synaptic connections

Patch-walking: Coordinated multi-pipette patch clamp for efficiently finding synaptic connections

Projection populations form a dorsoventral gradient of reward representations in the lateral septum

Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer’s disease

Regional susceptibility of PV interneurons in an hAPP-KI mouse model of Alzheimer’s disease pathology

Selective targeting of hippocampal fast-spiking basket cell interneurons via noninvasive enhancer-AAV delivery

Ultrafast Simulation of Large-Scale Neocortical Microcircuitry with Biophysically Realistic Neurons

‘Hidden’ HCN channels permit pathway-specific synaptic amplification in L2/3 pyramidal neurons