Packianathan, Charles

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Packianathan, Charles

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selected scholarly works & creative activities

Article
- 2019
  
  Structures of two ArsR As(III)-responsive transcriptional repressors: Implications for the mechanism of derepression. Journal of Structural Biology. 207:209-217.
  Full Text via DOI: 10.1016/j.jsb.2019.05.009 Web of Science: 000477692100010
- 2018
  
  The Structure of an As(III) S-Adenosylmethionine Methyltransferase with 3-Coordinately Bound As(III) Depicts the First Step in Catalysis. Biochemistry. 57:4083-4092.
  Full Text via DOI: 10.1021/acs.biochem.8b00457 Web of Science: 000439397900006
- 2018
  
  Reorientation of the Methyl Group in MAs(III) is the Rate-Limiting Step in the ArsM As(III) S-Adenosylmethionine Methyltransferase Reaction. ACS Omega. 3:3104-3112.
  Full Text via DOI: 10.1021/acsomega.8b00197 Web of Science: 000427939400068
- 2018
  
  Arsenic methylation by a novel ArsM As(III) S-adenosylmethionine methyltransferase that requires only two conserved cysteine residues. Molecular Microbiology. 107:265-276.
  Full Text via DOI: 10.1111/mmi.13882 Web of Science: 000419518900009
- 2015
  
  High-throughput screening-compatible assays of As(III) S-adenosylmethionine methyltransferase activity. Analytical Biochemistry. 480:67-73.
  Full Text via DOI: 10.1016/j.ab.2015.04.011 Web of Science: 000354912300012
- 2015
  
  A disulfide-bond cascade mechanism for arsenic(III) S-adenosylmethionine methyltransferase. Acta Crystallographica Section D: Structural Biology. 71:505-515.
  Full Text via DOI: 10.1107/S1399004714027552 Web of Science: 000351155400009
- 2014
  
  Pathway of Human AS3MT Arsenic Methylation. Chemical Research in Toxicology. 27:1979-1989.
  Full Text via DOI: 10.1021/tx500313k Web of Science: 000345264300011
- 2014
  
  Crystallization and preliminary X-ray crystallographic studies of CrArsM, an arsenic(III) S-adenosylmethionine methyltransferase from Chlamydomonas reinhardtii. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS. 70:1385-1388.
  Full Text via DOI: 10.1107/S2053230X14018469 Web of Science: 000343060200016
- 2013
  
  Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities. Biochemical and Biophysical Research Communications. 440:277-282.
  Full Text via DOI: 10.1016/j.bbrc.2013.09.077 Web of Science: 000326137700014
- 2012
  
  Identification of an S-adenosylmethionine (SAM) dependent arsenic methyltransferase in Danio rerio. Toxicology and Applied Pharmacology. 262:185-193.
  Full Text via DOI: 10.1016/j.taap.2012.04.035 Web of Science: 000305845400010
- 2012
  
  Structure of an As(III) S-Adenosylmethionine Methyltransferase: insights into the Mechanism of Arsenic Biotransformation. Biochemistry. 51:5476-5485.
  Full Text via DOI: 10.1021/bi3004632 Web of Science: 000306203100011
Conference
- 2014
  
  Enzymes of arsenic biotransformation. Journal of Biological Inorganic Chemistry. S178-S178.
  Web of Science: 000332835300120

principal investigator on

Understanding the pathways of human AS3MT using X-ray crystallography awarded by DrHerbert & Nicole Wertheim Family Found 2017 - 2020

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