FIU Discovery

A cancer-associated RNA polymerase III identity drives robust transcription and expression of snaR-A noncoding RNA

Monocyte-released HERV-K dUTPase engages TLR4 and MCAM causing endothelial mesenchymal transition

PPAR gamma Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis.  CELL REPORTS.  26:1333-+.

Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1

Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA

Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases

PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption.  EBIOMEDICINE.  10:174-184.

PPAR gamma Antagonist Gleevec Improves Insulin Sensitivity and Promotes the Browning of White Adipose Tissue

Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPAR gamma Antagonists.  ACS MEDICINAL CHEMISTRY LETTERS.  6:998-1003.

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers.  NATURE COMMUNICATIONS.  6.

Pharmacological repression of PPAR gamma promotes osteogenesis.  NATURE COMMUNICATIONS.  6.

Identification of Bexarotene as a PPAR gamma Antagonist with HDX

HDX-MS guided drug discovery: small molecules and biopharmaceuticals

An alternate binding site for PPAR gamma ligands.  NATURE COMMUNICATIONS.  5.

Antidiabetic actions of a non-agonist PPAR gamma ligand blocking Cdk5-mediated phosphorylation.  NATURE.  477:477-U131.

The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu.  PROTEIN SCIENCE.  19:2131-2140.

A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from Bacteroides thetaiotaomicron at 2.2 angstrom resolution

Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas campestris pv. campestris

Open and closed conformations of two SpoIIAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding

Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules

Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 angstrom resolution: the first structural representative of a new protein family that may play a role in carbohydrate metabolism

Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism

Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron

Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15

Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster

Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and Rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation

Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism

Structure of the gamma-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-gamma-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases

Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism

Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction

Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved alpha plus beta core domain and an auxiliary C-terminal treble-clef zinc finger

The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function

The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes

The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 angstrom resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator

The structure of KPN03535 (gi vertical bar 152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold

The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role

The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism

The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation

Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA Repair.  JOURNAL OF MOLECULAR BIOLOGY.  397:647-663.

Bacterial Pleckstrin Homology Domains: A Prokaryotic Origin for the PH Domain.  JOURNAL OF MOLECULAR BIOLOGY.  396:31-46.

Structural and Functional Characterizations of SsgB, a Conserved Activator of Developmental Cell Division in Morphologically Complex Actinomycetes.  JOURNAL OF BIOLOGICAL CHEMISTRY.  284:25268-25279.

Crystal Structure of Histidine Phosphotransfer Protein ShpA, an Essential Regulator of Stalk Biogenesis in Caulobacter crescentus.  JOURNAL OF MOLECULAR BIOLOGY.  390:686-698.

Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 angstrom resolution.  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS.  75:296-307.

Crystal structure of the Fic (Filamentation Induced by cAMP) family protein SO4266 (gi vertical bar 24375750) from Shewanella oneidensis MR-1 at 1.6 angstrom resolution.  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS.  75:264-271.

Structural Basis of Murein Peptide Specificity of a gamma-D-Glutamyl-L-Diamino Acid Endopeptidase

A Structural Basis for the Regulatory Inactivation of DnaA.  JOURNAL OF MOLECULAR BIOLOGY.  385:368-380.

Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold.  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS.  71:1589-1596.

Fragment-based discovery of hepatitis C virus NS5b RNA polymerase inhibitors.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS.  18:2990-2995.

Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif.  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS.  69:223-233.

Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA.  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS.  69:234-243.

Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 angstrom resolution.  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS.  68:999-1005.

Personalized Metabolomics.  447-456.

A cancer-associated RNA polymerase III identity drives robust transcription and expression of SNAR-A noncoding RNA

Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks

Defining a canonical ligand-binding pocket in the orphan nuclear receptor Nurr1

The Therapeutic Potential of Nuclear Receptor Modulators for Treatment of Metabolic Disorders: PPAR gamma, RORs, and Rev-erbs.  193-208.