Overview
overview
- Dr. Jun Li is an Associate Professor in the Department of Biological Sciences. He studies vector biology and host-pathogen interaction. His group has successfully identified one novel pathway mediating Plasmodium parasite invasion in mosquitoes, a candidate protein as a malaria vaccine antigen, and a compound to block malaria transmission. As a PI, he has led several research projects supported by NSF CAREER award and NIH Research grants.
Publications
selected scholarly works & creative activities
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Article
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2025Transcriptome Analysis of Culex pipiens quinquefasciatus Larvae Exposed to a Semi-Lethal Dose of Vermistatin. Tropical Medicine and Infectious Disease. 10.Full Text via DOI: 10.3390/tropicalmed10020031 Web of Science: 001429571800001
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2024Leucinostatins target Plasmodium mitochondria to block malaria transmission. Parasites and Vectors. 17.Full Text via DOI: 10.1186/s13071-024-06608-8 Web of Science: 001381577800004
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2024Leucinostatins from fungal extracts block malaria transmission to mosquitoes. Parasites and Vectors. 17.Full Text via DOI: 10.1186/s13071-024-06450-y Web of Science: 001317777300001
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2024FcRider: a recombinant Fc nanoparticle with endogenous adjuvant activities for hybrid immunization. ANTIBODY THERAPEUTICS. 7:295-306.Full Text via DOI: 10.1093/abt/tbae023 Web of Science: 001306620400001
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2024Functional characterization of a conserved membrane protein, Pbs54, involved in gamete fertilization in Plasmodium berghei. International Journal for Parasitology. 54:99-107.Full Text via DOI: 10.1016/j.ijpara.2023.08.003 Web of Science: 001167649100001
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2023Talaromyces sp. Ethyl Acetate Crude Extract as Potential Mosquitocide to Control Culex pipiens quinquefasciatus. Molecules. 28.Full Text via DOI: 10.3390/molecules28186642 Web of Science: 001074161200001
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2023Plasmodium parasitophorous vacuole membrane protein Pfs16 promotes malaria transmission by silencing mosquito immunity. Journal of Biological Chemistry. 299.Full Text via DOI: 10.1016/j.jbc.2023.104824 Web of Science: 001433679100001
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2023Arsinothricin Inhibits Plasmodium falciparum Proliferation in Blood and Blocks Parasite Transmission to Mosquitoes. Microorganisms. 11.Full Text via DOI: 10.3390/microorganisms11051195 Web of Science: 000998111500001
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2023Targeting plasmodium α-tubulin-1 to block malaria transmission to mosquitoes. Frontiers in Cellular and Infection Microbiology. 13.Full Text via DOI: 10.3389/fcimb.2023.1132647 Web of Science: 000961245000001
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2023Cyprinid herpesvirus 2 infection changes microbiota and metabolites in the gibel carp (Carassius auratus gibelio) midgut. Frontiers in Cellular and Infection Microbiology. 12.Full Text via DOI: 10.3389/fcimb.2022.1017165 Web of Science: 000937299700001
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2022An Eco-Friendly Conversion of Aquaculture Suspended Solid Wastes Into High-Quality Fish Food by Improving Poly-β-Hydroxybutyrate Production. Frontiers in Physiology. 13.Full Text via DOI: 10.3389/fphys.2022.797625 Web of Science: 000812954900001
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2022Crystal Structure Determination and Hirshfeld Analysis of a New Alternariol Packing Polymorph. Crystals. 12.Full Text via DOI: 10.3390/cryst12050579 Web of Science: 000801550900001
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2021Discovery of mosquitocides from fungal extracts through a high-throughput cytotoxicity-screening approach. Parasites and Vectors. 14.Full Text via DOI: 10.1186/s13071-021-05089-3 Web of Science: 000726281100002
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2021Sterigmatocystin Limits Plasmodium falciparum Proliferation and Transmission. Pharmaceuticals. 14.Full Text via DOI: 10.3390/ph14121238 Web of Science: 000736901600001
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2021Studies of the Parasite-Midgut Interaction Reveal Plasmodium Proteins Important for Malaria Transmission to Mosquitoes. Frontiers in Cellular and Infection Microbiology. 11.Full Text via DOI: 10.3389/fcimb.2021.654216 Web of Science: 000671942600001
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2021A novel fungal metabolite inhibits Plasmodium falciparum transmission and infection. Parasites and Vectors. 14.Full Text via DOI: 10.1186/s13071-021-04677-7 Web of Science: 000632382300001
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2020Measurement of single-diffractive dijet production in proton-proton collisions at √s=8 TeV with the CMS and TOTEM experiments. European Physical Journal C. 80.Full Text via DOI: 10.1140/epjc/s10052-020-08562-y Web of Science: 000600230600003
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2020A diverse global fungal library for drug discovery. PeerJ. 8.Full Text via DOI: 10.7717/peerj.10392 Web of Science: 000593689800003
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2020Analysis of blood-induced Anopheles gambiae midgut proteins and sexual stage Plasmodium falciparum interaction reveals mosquito genes important for malaria transmission. Scientific Reports. 10.Full Text via DOI: 10.1038/s41598-020-71186-5 Web of Science: 000570035500063
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2020Fungal Metabolite Asperaculane B Inhibits Malaria Infection and Transmission. Molecules. 25.Full Text via DOI: 10.3390/molecules25133018 Web of Science: 000550294000001
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2020Search for a Narrow Resonance Lighter than 200 GeV Decaying to a Pair of Muons in Proton-Proton Collisions at √s=13 TeV. Physical Review Letters. 124.Full Text via DOI: 10.1103/PhysRevLett.124.131802 Web of Science: 000523412800003
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2019Jet Shapes of Isolated Photon-Tagged Jets in Pb-Pb and pp Collisions at √SNN=5.02 TeV. Physical Review Letters. 122.Full Text via DOI: 10.1103/PhysRevLett.122.152001 Web of Science: 000465181700001
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2019Observation of Single Top Quark Production in Association with a Z Boson in Proton-Proton Collisions at √s=13 TeV. Physical Review Letters. 122.Full Text via DOI: 10.1103/PhysRevLett.122.132003 Web of Science: 000463901800006
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2019Observation of Two Excited Bc+ States and Measurement of the Bc+ (2S) Mass in pp Collisions at √s=13 TeV. Physical Review Letters. 122.Full Text via DOI: 10.1103/PhysRevLett.122.132001 Web of Science: 000463900300005
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2019Combination of Searches for Higgs Boson Pair Production in Proton-Proton Collisions at √s=13 TeV. Physical Review Letters. 122.Full Text via DOI: 10.1103/PhysRevLett.122.121803 Web of Science: 000462936700008
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2019Search for Narrow Hγ Resonances in Proton-Proton Collisions at √s=13 TeV. Physical Review Letters. 122.Full Text via DOI: 10.1103/PhysRevLett.122.081804 Web of Science: 000460667600005
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2019A Low Frequency Mechanical Transmitter Based on Magnetoelectric Heterostructures Operated at Their Resonance Frequency. Sensors. 19.Full Text via DOI: 10.3390/s19040853 Web of Science: 000460829200104
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2017Tracking the morphology and phase transformations of anodic iron oxide nanotubes using X-ray spectroscopy. Journal of Electron Spectroscopy and Related Phenomena. 220:109-113.Full Text via DOI: 10.1016/j.elspec.2016.11.009
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2017FBN30 in wild Anopheles gambiae functions as a pathogen recognition molecule against clinically circulating Plasmodium falciparum in malaria endemic areas in Kenya. Scientific Reports. 7.Full Text via DOI: 10.1038/s41598-017-09017-3 Web of Science: 000407864000044
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2017The fibrinogen-like domain of FREP1 protein is a broad-spectrum malaria transmission-blocking vaccine antigen. Journal of Biological Chemistry. 292:11960-11969.Full Text via DOI: 10.1074/jbc.M116.773564 Web of Science: 000405485600031
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2017Nonsynonymous Polymorphisms in the Human AS3MT Arsenic Methylation Gene: Implications for Arsenic Toxicity. Chemical Research in Toxicology. 30:1481-1491.Full Text via DOI: 10.1021/acs.chemrestox.7b00113 Web of Science: 000405972100011
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2017Modulation-Doped In2O3/ZnO Heterojunction Transistors Processed from Solution. Advanced Materials. 29.Full Text via DOI: 10.1002/adma.201605837
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2017Conserved cysteine residues determine substrate specificity in a novel As(III) S-adenosylmethionine methyltransferase from Aspergillus fumigatus. Molecular Microbiology. 104:250-259.Full Text via DOI: 10.1111/mmi.13628 Web of Science: 000398569900004
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2017Response of gaseous carbon emissions to low-level salinity increase in tidal marsh ecosystem of the Min River estuary, southeastern China. Journal of Environmental Sciences. 52:210-222.Full Text via DOI: 10.1016/j.jes.2016.05.009
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2016Structures of PspAG97A α-glucoside hydrolase reveal a novel mechanism for chloride induced activation. Journal of Structural Biology. 196:426-436.Full Text via DOI: 10.1016/j.jsb.2016.09.009 Web of Science: 000389295000015
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2016Small fungal molecule metabolites targeting mosquito midgut FREP1 block malaria transmission. The FASEB Journal. 30.Full Text via DOI: 10.1096/fasebj.30.1_supplement.627.6
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2015Targeting mosquito FREP1 with a fungal metabolite blocks malaria transmission. Scientific Reports. 5.Full Text via DOI: 10.1038/srep14694 Web of Science: 000362258300001
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2015Anopheles Midgut FREP1 Mediates Plasmodium Invasion. Journal of Biological Chemistry. 290:16490-16501.Full Text via DOI: 10.1074/jbc.M114.623165 Web of Science: 000357572800003
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2015PD-1 Co-inhibitory and OX40 Co-stimulatory Crosstalk Regulates Helper T Cell Differentiation and Anti-Plasmodium Humoral Immunity. Cell Host and Microbe. 17:628-641.Full Text via DOI: 10.1016/j.chom.2015.03.007 Web of Science: 000356101500014
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2015Co-inhibitory and co-stimulatory crosstalk regulates helper T cell differentiation and humoral immunity during Plasmodium infection (MPF5P.742). Journal of Immunology. 194:137.5-137.5.Full Text via DOI: 10.4049/jimmunol.194.supp.137.5
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2015Constructing a Genome-Wide LD Map of Wild A. gambiae Using Next-Generation Sequencing. BioMed Research International. 2015.Full Text via DOI: 10.1155/2015/238139 Web of Science: 000361200400001
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2013Genome-block expression-assisted association studies discover malaria resistance genes in Anopheles gambiae. Proceedings of the National Academy of Sciences of the United States of America. 110:20675-20680.Full Text via DOI: 10.1073/pnas.1321024110 Web of Science: 000328548600073
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2013Genomic law guided gene prediction in fungi and metazoans. International Journal of Computational Biology and Drug Design. 6:157-169.Full Text via DOI: 10.1504/IJCBDD.2013.052197
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2012Comparative Transcriptome Analyses of Deltamethrin-Resistant and - Susceptible Anopheles gambiae Mosquitoes from Kenya by RNA-Seq. PLoS ONE. 7.Full Text via DOI: 10.1371/journal.pone.0044607 Web of Science: 000308462000037
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2010Allelic Gene Structure Variations in Anopheles gambiae Mosquitoes. PLoS ONE. 5.Full Text via DOI: 10.1371/journal.pone.0010699 Web of Science: 000277845400009
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2006Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region. Science. 312:577-579.Full Text via DOI: 10.1126/science.1124153 Web of Science: 000237296700045
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2006Anopheles gambiae genome reannotation through synthesis of ab initio and comparative gene prediction algorithms. Genome Biology. 7.Full Text via DOI: 10.1186/gb-2006-7-3-r24 Web of Science: 000237298700014
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2006A mosquito-specific protein family includes candidate receptors for malaria sporozoite invasion of salivary glands. Cellular Microbiology. 8:163-175.Full Text via DOI: 10.1111/j.1462-5822.2005.00611.x Web of Science: 000233817900015
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1999Bovine CD18 identified as a species specific receptor for Pasteurella haemolytica leukotoxin. Veterinary Microbiology. 67:91-97.Full Text via DOI: 10.1016/S0378-1135(99)00040-1 Web of Science: 000080908200002
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1999Lipopolysaccharide complexes with Pasteurella haemolytica leukotoxin. Infection and Immunity. 67:2920-2927.Full Text via DOI: 10.1128/IAI.67.6.2920-2927.1999 Web of Science: 000080473600031
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1995High-level excretion of heterologous proteins from E-coli directed by protein A singal peptide. Acta Biochimica et Biophysica Sinica. 27:616-623.Web of Science: A1995TM26400004
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Book Chapter
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2005Molecular genetics of mosquito resistance to malaria parasites. 383-415.Web of Science: 000233456400015
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Conference
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2021A DIVERSE GLOBAL FUNGAL LIBRARY FOR DRUG DISCOVERY. American Journal of Tropical Medicine and Hygiene. 204-204.Web of Science: 000778105602327
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2021A NEW MOSQUITO MIDGUT PROTEIN AGAP008138 FACILITATES PLASMODIUM FALCIPARUM TRANSMISSION IN ANOPHELES GAMBIAE MOSQUITOES. American Journal of Tropical Medicine and Hygiene. 41-41.Web of Science: 000778105601125
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2021FUNGAL METABOLITE ASPERACULANE B INHIBITS MALARIA INFECTION AND TRANSMISSION. American Journal of Tropical Medicine and Hygiene. 67-67.Web of Science: 000778105601211
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2021MOLECULAR MECHANISMS OF PLASMODIUM CANDIDATE PROTEINS INTERACTION DURING PARASITE INVASION OF MIDGUTS. American Journal of Tropical Medicine and Hygiene. 364-364.Web of Science: 000778105603232
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2021STUDIES OF THE PARASITE-MIDGUT INTERACTION REVEAL PLASMODIUM PROTEINS IMPORTANT FOR MALARIA TRANSMISSION TO MOSQUITOES. American Journal of Tropical Medicine and Hygiene. 59-59.Web of Science: 000778105601185
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2020Leveraging Stragglers in Coded Computing with Heterogeneous ServersFull Text via DOI: 10.1109/iwqos49365.2020.9213028 Web of Science: 000629047500040
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2020Local Re-encoding for Coded Matrix Multiplication. 2017 IEEE INTERNATIONAL SYMPOSIUM ON INFORMATION THEORY (ISIT). 221-226.Full Text via DOI: 10.1109/isit44484.2020.9174041 Web of Science: 000714963400038
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2020Straggler-free Coding for Concurrent Matrix Multiplications. 2017 IEEE INTERNATIONAL SYMPOSIUM ON INFORMATION THEORY (ISIT). 233-238.Full Text via DOI: 10.1109/isit44484.2020.9174239 Web of Science: 000714963400040
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2019EXPLORING FUNGAL METABOLITES FOR MALARIA TRANSMISSION BLOCKING AGENTS. American Journal of Tropical Medicine and Hygiene. 285-285.Web of Science: 000507364503286
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2019INTERACTION BETWEEN PLASMODIUMAL PHATUBULIN AND ANOPHELES FREP1 ASSISTS MALARIA TRANSMISSION. American Journal of Tropical Medicine and Hygiene. 220-220.Web of Science: 000507364503068
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2019SMALL MOLECULE ASPERACULANE B INHIBITS MALARIA INFECTION AND TRANSMISSION. American Journal of Tropical Medicine and Hygiene. 92-92.Web of Science: 000507364502303
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2006Quantitative analysis of the Anopheles gambiae hemolymph immune proteome. American Journal of Tropical Medicine and Hygiene. 6-6.Web of Science: 000242343900022
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Preprint
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Review
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2023Beyond antibody fucosylation: α-(1,6)-fucosyltransferase (Fut8) as a potential new therapeutic target for cancer immunotherapy. ANTIBODY THERAPEUTICS. 87-96.Full Text via DOI: 10.1093/abt/tbad004 Web of Science: 001324952700001
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2021Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission. npj Vaccines.Full Text via DOI: 10.1038/s41541-021-00401-9 Web of Science: 000723649900003
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2021Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy. 1-382.Full Text via DOI: 10.1080/15548627.2020.1797280 Web of Science: 000636121800001
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2017Overview on the Current Status of Zika Virus Pathogenesis and Animal Related Research. Journal of NeuroImmune Pharmacology. 371-388.Full Text via DOI: 10.1007/s11481-017-9743-8 Web of Science: 000406359000001
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Research
principal investigator on
- CIF: Small: Coding Techniques for Distributed Machine Learning awarded by National Science Foundation 2019 - 2022
Contact
full name
- Jun Li
