FIU Discovery

The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-implications for the toxic gain of function observed in ALS.  Neurobiology of Disease.  217.

The structure, redox chemistry and motor neuron toxicity of heterodimeric zinc-deficient SOD1-Implications for the toxic gain of function observed in ALS..  bioRxiv. 

ProDiVis: a method to normalize fluorescence signal localization in 3D specimens.  Frontiers in Cell and Developmental Biology.  12.

Selective nitration of Hsp90 acts as a metabolic switch promoting tumor cell proliferation.  Redox Biology.  75.

Tailored electrocardiographic-based criteria for different pacing locations within the left bundle branch.  Europace.  26:euae102.385.

Can peak left ventricular activation time measured in aVL identify left bundle capture during left bundle branch area pacing?.  Europace.  24:euac053.434.

Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation.  Redox Biology.  50.

Do we need cardiopulmonary exercise to determine the optimal time for intervention in valvular heart disease?.  European Heart Journal.  41:ehaa946.1915.

Prognostic role of NYHA class in heart failure patients undergoing primary prevention ICD therapy.  ESC heart failure.  7:280-284.

P2750Why should cardiopulmonary exercise testing be routinely used for assessing patients with valvular heart disease?.  European Heart Journal.  40:ehz748.1067.

P5425Prognostic value of NYHA functional class in heart failure patients undergoing primary prevention implantable cardioverter defibrillator therapy.  European Heart Journal.  40:ehz746.0382.

P5680One-year outcomes of heart failure patients undergoing cardiac resynchronization therapy using adaptivCRT algorithm.  European Heart Journal.  40:ehz746.0622.

Highlight article: Ligand-independent activation of the P2X7 receptor by Hsp90 inhibition stimulates motor neuron apoptosis.  Experimental Biology and Medicine.  244:901-914.

Survival and arrhythmic risk among ischemic and non-ischemic heart failure patients with prophylactic implantable cardioverter defibrillator only therapy: A propensity score-matched analysis.  International Journal of Cardiology.  274:163-169.

P3453Survival and arrhythmic mortality among ischemic and non-ischemic heart failure patients undergoing ICD-only therapy for primary prevention strategy.  European Heart Journal.  39:ehy563.p3453.

P1741Arrhythmic risk among ischemic and non-ischemic heart failure patients with narrow QRS: insigths from the umbrella registry.  Europace.  19:iii379-iii379.

P1744Inappropriate therapies in primary prevention ICD patients with narrow QRS: dual or single chamber ICD? The question remains.  Europace.  19:iii380-iii381.

Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis.  Journal of Neuroscience.  37:1413-1427.

Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD^G93A mice co-expressing the Copper-Chaperone-for-SOD.  Neurobiology of Disease.  89:1-9.

Chronic inhibitory effect of riluzole on trophic factor production.  Experimental Neurology.  271:301-307.

Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism.  Journal of Biological Chemistry.  290:19055-19066.

Reactive nitrogen species in cellular signaling.  Experimental Biology and Medicine.  240:711-717.

Nitration of Hsp90 induces cell death.  Proceedings of the National Academy of Sciences of the United States of America.  110:E1102-E1111.

Temporal patterns of tyrosine nitration in embryo heart development.  Free Radical Biology and Medicine.  55:101-108.

Mitochondrial Dynamics and Bioenergetic Dysfunction Is Associated with Synaptic Alterations in Mutant SOD1 Motor Neurons.  Journal of Neuroscience.  32:229-242.

Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex.  Journal of Biological Chemistry.  286:17640-17648.

Cu, Zn-Superoxide Dismutase Increases Toxicity of Mutant and Zinc-deficient Superoxide Dismutase by Enhancing Protein Stability.  Journal of Biological Chemistry.  285:33885-33897.

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis.  PLoS ONE.  4.

gamma-Aminobutyric Acid-Mediated Regulation of the Activity-Dependent Olfactory Bulb Dopaminergic Phenotype.  Journal of Neuroscience Research.  87:2211-2221.

Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for multiple sclerosis.  Journal of Neurochemistry.  109:93-104.

Mitigation of peroxynitrite-mediated nitric oxide (NO) toxicity as a mechanism of induced adaptive NO resistance in the CNS.  Journal of Neurochemistry.  109:74-84.

Characteristics and Outcome of Angiographically Confirmed Stent Thrombosis.  Revista española de cardiología (English ed.).  62:220-223.

Long-term Outcome of Infective Endocarditis in Non-Intravenous Drug Users.  Mayo Clinic proceedings.  83:1213-1217.

Chest Pain in the Emergency Department: Incidence, Clinical Characteristics and Risk Stratification.  Revista española de cardiología (English ed.).  61:953-959.

Control of Muscle Mitochondria by Insulin Entails Activation of Akt2-mtNOS Pathway: Implications for the Metabolic Syndrome.  PLoS ONE.  3.

Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression.  Journal of Neuroscience.  27:7929-7938.

Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells.  Cell Death and Differentiation.  13:1506-1514.

Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons.  Journal of Neuroscience.  26:8512-8516.

Interactions between β-neuregulin and neurotrophins in motor neuron apoptosis.  Journal of Neurochemistry.  97:222-233.

S-nitrosothiol depletion in amyotrophic lateral sclerosis.  Proceedings of the National Academy of Sciences of the United States of America.  103:2404-2409.

A new risk score for patients with a normal or non-diagnostic ECG admitted to a chest pain unit.  Revista española de cardiología (English ed.).  58:782-788.

Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis.  Journal of Neurochemistry.  93:38-46.

Biosynthesis and catabolism of prostaglandin F₂(alpha) (PGF_2α) are controlled by progesterone in the rat uterus during pregnancy.  Journal of Steroid Biochemistry and Molecular Biology.  91:211-218.

Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine.  Journal of Neurochemistry.  89:602-612.

Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis.  Journal of Neurochemistry.  89:464-473.

Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease.  Proceedings of the National Academy of Sciences of the United States of America.  100:12171-12176.

Ccs knockout mice establish an alternative source of copper for SOD in ALS.  Free Radical Biology and Medicine.  33:1433-1435.

Motoneuron death triggered by a specific pathway downstream of Fas: Potentiation by ALS-linked SOD1 mutations.  Neuron.  35:1067-1083.

Cyclic guanosine 5 ' monophosphate (GMP) prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors in rats.  Neuroscience Letters.  326:201-205.

Nitric oxide and superoxide, a deadly cocktail.  Annals of the New York Academy of Sciences.  962:207-211.

Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis.  Journal of Neuroscience Research.  67:21-29.

Superoxide dismutase and the death of motoneurons in ALS.  Trends in Neurosciences.  24:15-20.

Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway.  American Journal of Physiology - Lung Cellular and Molecular Physiology.  279:L994-L1002.

Liposome-delivered superoxide dismutase prevents nitric oxide-dependent motor neuron death induced by trophic factor withdrawal.  Free Radical Biology and Medicine.  28:437-446.

Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase.  Science.  286:2498-2500.

Microtubule dysfunction by posttranslational nitrotyrosination of α-tubulin:: A nitric oxide-dependent mechanism of cellular injury.  Proceedings of the National Academy of Sciences of the United States of America.  96:6365-6370.

Binding of xanthine oxidase to vascular endothelium - Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling.  Journal of Biological Chemistry.  274:4985-4994.

Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21 Ras activation and is suppressed by Bcl-2.  Archives of Biochemistry and Biophysics.  356:41-45.

Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor.  Journal of Neuroscience.  18:3708-3714.

Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation.  Journal of Neuroscience.  18:923-931.

Nerve growth factor protects PC12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase.  Journal of Neurochemistry.  69:53-59.

Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers.  Neuroscience Letters.  228:207-211.

PEROXYNITRITE-INDUCED CYTOTOXICITY IN PC12 CELLS - EVIDENCE FOR AN APOPTOTIC MECHANISM DIFFERENTIALLY MODULATED BY NEUROTROPHIC FACTORS.  Journal of Neurochemistry.  65:1543-1550.

PROTECTIVE EFFECT OF RILUZOLE ON EXCITATORY AMINO ACID-MEDIATED NEUROTOXICITY IN MOTONEURON-ENRICHED CULTURES.  European Journal of Pharmacology.  280:47-53.

EFFECT OF FOLLICLE-STIMULATING-HORMONE ON INSULIN-LIKE GROWTH FACTOR-I-STIMULATED RAT GRANULOSA-CELL DEOXYRIBONUCLEIC-ACID SYNTHESIS.  Endocrinology.  131:1223-1229.

Effect of follicle-stimulating hormone on insulin-like growth factor-I-stimulated rat granulosa cell deoxyribonucleic acid synthesis.  Endocrinology.  131:1223-1229.

TUNICAMYCIN INHIBITS THE INITIATION OF DNA-SYNTHESIS STIMULATED BY PROSTAGLANDIN-F2-ALPHA IN SWISS MOUSE 3T3 CELLS.  FEBS Letters.  290:239-242.

Role of dolichol in the control of DNA replication in swiss mouse 3T3 cells.  Cell Biology International.  14:127.

GABA AND ITS NEURAL REGULATION IN RAT BROWN ADIPOSE-TISSUE.  Journal of Neural Transmission.  78:17-28.

TIME-DEPENDENT EFFECT OF MELATONIN ON GLUTAMIC-ACID DECARBOXYLASE ACTIVITY AND CL-36(-) INFLUX IN RAT HYPOTHALAMUS.  Journal of Neuroendocrinology.  1:443-447.

CELL-SURFACE GLYCOCONJUGATES CONTROL THE ACTIVITY OF THE NADH-ASCORBATE FREE-RADICAL REDUCTASE OF RAT-LIVER PLASMA-MEMBRANE.  Biochemical and Biophysical Research Communications.  154:1029-1033.

BENZODIAZEPINE BINDING-SITES IN RAT INTERSCAPULAR BROWN ADIPOSE-TISSUE - EFFECT OF COLD ENVIRONMENT, DENERVATION AND ENDOCRINE ABLATIONS.  Life Sciences.  42:393-402.

NORMAL SERUM-PROTEINS IN FEMALE BREAST CARCINOMAS AND FIBROADENOMAS - AN IMMUNOHISTOCHEMICAL STUDY.  Annales de Pathologie.  7:209-215.

SERUM IMMUNOGLOBULIN A CHANGES IN ALCOHOLIC PATIENTS.  Annals of Clinical Research.  9:39-43.

LAPAROSCOPIC ADNEXECTOMY OF A GONADOBLASTOMA.  Journal of Gynecologic Surgery.  8:87-89.

Stimulation of nerve growth factor expression in astrocytes by peroxynitrite.  In Vivo.  18:269-274.

Triterpenoid and phenolic compounds from two Chilean Celastraceae.  Zeitschrift für Naturforschung - Section C Journal of Biosciences.  54:144-145.

Examining apoptosis in cultured cells after exposure to nitric oxide and peroxynitrite.  Ed. 301. 

Immunohistochemical methods to detect nitrotyrosine.  Ed. 301. 

Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture.  Ed. 118. 

Amyotrophic Lateral Sclerosis: Present Understanding of the Role of SOD.  597-603.

Pathophysiology of Amyotrophic Lateral Sclerosis

Superoxide Dismutase and Oxidative Stress in Amyotrophic Lateral Sclerosis

Reactive Nitrogen Species in Motor Neuron Apoptosis.  313-334.

Peroxynitrite and injury to the vasculature and central nervous system in stroke and neurodegeneration.  23-46.

Roles for Fas in programmed cell death of motoneurons.  33-45.

Nitric Oxide Toxicity in Neuronal Injury and Degeneration.  262-278.

Peroxynitrite and Cell Signaling.  32-51.

CONCERTED MITOGENIC SIGNALS CONTROL MAMMALIAN DNA-REPLICATION PROTEIN-KINASE-C ROLE.  213-218.

Single- vs dual-chamber ICDs to prevent from inappropriate shocks: the debate is still alive.  European Heart Journal. 686-686.

Validation of leadless atrioventricular synchronous pacing with Holter-ECG: a pilot study.  European Heart Journal. 674-674.

Apoptotic Signaling Pathways Activated by Peroxynitrite-Mediated Nitration.  Free Radical Biology and Medicine. S13-S13.

A Biochemical and Biophysical Investigation into the Pathological Gain -of-Function of Nitrated Hsp90.  Free Radical Biology and Medicine. S29-S29.

Nitrated Hsp90 Mediates Peroxynitrite-Induced Apoptosis.  Free Radical Biology and Medicine. S102-S102.

RISK OF LIFE-THREATENING ARRHYTHMIC EVENTS IN NON-ISCHEMIC HEART FAILURE PATIENTS WITH PROPHYLACTIC CARDIOVERTER DEFIBRILLATOR.  Journal of the American College of Cardiology. 485-485.

ALS and the role of zinc and copper bound to superoxide dismutase.  Journal of Neurochemistry. 61-61.

NITRATED HSP90 DECREASES MITOCHONDRIAL MEMBRANE POTENTIAL AND OXYGEN CONSUMPTION.  Journal of Neurochemistry. 153-153.

NITRATED HSP90 INDUCES APOPTOSIS IN MOTOR NEURONS BY A FAS-DEPENDENT MECHANISM.  Journal of Neurochemistry. 211-211.

Nitration of a Single HSP90 Tyrosine Residue is Sufficient to Induce Cell Death.  Free Radical Biology and Medicine. S74-S75.

Indications, description, and results or percutaneous transcatheter repairs of mitral paravalvular regurgitations.  American Journal of Cardiology. 59L-59L.

Infective endocarditis in non intravenous drug users: determinants of long term survival after discharge.  Clinical Research in Cardiology. 439-440.

Induction therapy in heart transplantation: A comparison between two-dose daclizumab and antithymocyte globulin therapy..  American Journal of Transplantation. 425-425.

ALS-associated Cu/Zn SOD mutant protein is linked to VEGF mRNA destabilization and down-regulation in vitro.  Neurology. A244-A245.

Arginase 1 prevents the death of trophic deprived motor neurons by inhibiting nitric oxide production.  Nitric Oxide - Biology and Chemistry. A67-A67.

Temporal expression profiles of vascular endothelial growth factor and inducible nitric oxide synthase in a transgenic mouse of amyotrophic lateral sclerosis.  Neurology. A137-A137.

A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis.  Brain Research Reviews. 263-274.

A two-locus FHM2 family with unique ATP1A2 mutation and comparative study in C-elegans showing regulation of tryptophan hydroxylase by EAT-6 and UNC-2, the orthologous FHM2 and FHM1 genes.  Cephalalgia. 149-150.

Nitric oxide renders motor neurons vulnerable to p75NTR mediated apoptosis.  Free Radical Biology and Medicine. S104-S104.

Peroxynitrite formation by zinc-deficient superoxide dismutase.  Free Radical Biology and Medicine. S22-S22.

Superoxide dismutase and motor neuron death in ALS.  Free Radical Biology and Medicine. S304-S304.

Zinc-deficient superoxide dismutase: A possible mechanism for ALS.  International Congress Series. 79-86.

Neuregulin supports the survival of embryonic rat spinal cord motor neurons..  Journal of Neuropathology and Experimental Neurology. 458-458.

Interactions between peroxynitrite and trophic support in apoptosis and cell survival.  243-249.

Peroxynitrite and superoxide dismutase in amyotrophic lateral sclerosis..  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U572-U572.

Post-translational nitrotyrosination of alpha-tubulin: A nitric oxide dependent mechanism of cytoskeletal dysfunction in inflammation.  Free Radical Biology and Medicine. S59-S59.

Post-translational nitrotyrosination of alpha-tubulin: A nitric oxide-dependent mechanism of cytoskeletal dysfunction in inflammation.  Free Radical Biology and Medicine. S45-S45.

SOD and ALS: Loss of zinc makes SOD toxic to motor neurons.  Free Radical Biology and Medicine. S110-S110.

Chest Pain With an Elevated Troponin Level but Without Significant Coronary Artery Disease Is Not Usually Due to an Infarction.  Revista española de cardiología (English ed.). 371-372.

The CPU-65 Risk Index: Validation and Clinical Value Response.  Revista española de cardiología (English ed.). 228-228.

Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells (vol 13, pg 1506, 2006).  Cell Death and Differentiation. 2563-2563.

Establishing Nitrated Hsp90 Cellular Interactome.  Free Radical Biology and Medicine.

Nitrated Hsp90 Supports Glioblastoma Multiforme Cell Survival by Maintaining P2X7 Receptor Activation.  Free Radical Biology and Medicine.

Site-Specific Nitration of Hsp90 Alters Cell Metabolism and Supports Schwannoma Cell Proliferation.  Free Radical Biology and Medicine.

A Computational Method to Visualize Nitrated Hsp90 Distribution in 3D Culture Models.  Free Radical Biology and Medicine. 36-36.

Nitrated Hsp90 Regulates Glioblastoma Multiforme Proliferation and Migration.  Free Radical Biology and Medicine. 34-34.

Nitration of Heat Shock Protein 90 Affects its Spatial Distribution and Promotes the Survival/Proliferation of Schwannoma Cells.  Free Radical Biology and Medicine. 32-32.

A Computational Method for the Visualization of Nitrated Hsp90 Distribution in 3D Culture Models.  The FASEB Journal.

Nitrated Hsp90 Supports Glioblastoma Multiforme Cell Survival and Migration.  The FASEB Journal.

Nitration of Hsp90 Affects its Spatial Distribution and Promotes Schwannoma Cell Proliferation.  The FASEB Journal.

Structural Changes Induced in Hsp90 by Nitration lead to a Pathological Gain-of-function.  The FASEB Journal.

Tyrosine Nitration Supports Gliobastoma Multiforme Cell Survival and Regulates Migration.  The FASEB Journal.

Impact of an adaptive CRT optimization algorithm on the risk of life-threatening ventricular arrythmias of heart failure patients.  European Heart Journal. 763-763.

Tyrosine Nitration Supports Glioblastoma Multiforme Cell Survival and Regulates Migration.  Free Radical Biology and Medicine. S59-S59.

Nitrated Hsp90-induced PC12 cell apoptosis requires p38 and JINK MAP kinase activation.  Nitric Oxide - Biology and Chemistry. 135-135.

Site-Specific Nitrated Hsp90 Is a Target for Drug Development in Cancer.  Free Radical Biology and Medicine. S125-S125.

Nitrated Hsp90 Regulates Mitochondrial Membrane Potential and Oxygen Consumption in Cancer Cells.  Free Radical Biology and Medicine. S42-S43.

Nitrated Hsp90 Decreases Mitochondrial Membrane Potential and Oxygen Consumption.  Free Radical Biology and Medicine. S28-S28.

Nitrated Hsp90 Induces Apoptosis in Motor Neurons by a Fas-Dependent Mechanism.  Free Radical Biology and Medicine. S28-S28.

Positive non-invasive tests in the chest pain unit: importance of the clinical profile for estimating the probability of coronary artery disease..  Acute Cardiac Care. 205-208.

Good science shows the way - Highlight Commentary on "Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice - A model of familial amyotrophic lateral sclerosis".  Free Radical Biology and Medicine. 163-164.

Permanent Cerebellar Degeneration After Acute Hyperthermia with Non-toxic Lithium Levels: a Case Report and Review of Literature.  Cerebellum. 973-978.

Cellular mechanisms of peroxynitrite-induced neuronal death.  Brain Research Bulletin. 4-11.

Tyrosine nitration as mediator of cell death.  Cellular and Molecular Life Sciences. 3939-3950.

Nitric Oxide-Mediated Oxidative Damage and the Progressive Demise of Motor Neurons in ALS.  Neurotoxicity Research. 251-264.

Harnessing hypoxic adaptation to prevent, treat, and repair stroke.  Journal of Molecular Medicine. 1331-1338.

Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides.  Journal of Biological Chemistry. 6324-6337.

Superoxide dismutase and the death of motoneurons in ALS.  Trends in Neurosciences. S15-S20.

Nitric oxide and peroxynitrite in the perinatal period.  Seminars in Perinatology. 37-41.