Estevez, Alvaro

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Estevez, Alvaro

Positions

Professor, Cellular and Molecular Medicine , Herbert Wertheim College of Medicine

alvestev@fiu.edu

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biography

Dr. Estevez is the Director of the PhD in Biomedical Sciences. His responsibilities include the overview of the program curriculum, and recruitment of graduate students.

research interests

Dr Estevez retired from active research activities to focus on the administration of the PhD in Biomedical Sciences graduate program.

selected scholarly works & creative activities

Article
- 2024
  
  ProDiVis: a method to normalize fluorescence signal localization in 3D specimens. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 12.
  Full Text via DOI: 10.3389/fcell.2024.1420161 Web of Science: 001329351600001
- 2024
  
  Selective nitration of Hsp90 acts as a metabolic switch promoting tumor cell proliferation. REDOX BIOLOGY. 75.
  Full Text via DOI: 10.1016/j.redox.2024.103249 Web of Science: 001283971800001
- 2024
  
  Tailored electrocardiographic-based criteria for different pacing locations within the left bundle branch
  Full Text via DOI: 10.1093/europace/euae102.385
- 2022
  
  Can peak left ventricular activation time measured in aVL identify left bundle capture during left bundle branch area pacing?
  Full Text via DOI: 10.1093/europace/euac053.434
- 2022
  
  Peroxynitrite nitration of Tyr 56 in Hsp90 induces PC12 cell death through P2X7R-dependent PTEN activation. REDOX BIOLOGY. 50.
  Full Text via DOI: 10.1016/j.redox.2022.102247 Web of Science: 000788270500001
- 2020
  
  Do we need cardiopulmonary exercise to determine the optimal time for intervention in valvular heart disease?. EUROPEAN HEART JOURNAL. 41:ehaa946.1915.
  Full Text via DOI: 10.1093/ehjci/ehaa946.1915
- 2020
  
  Prognostic role of NYHA class in heart failure patients undergoing primary prevention ICD therapy
  Full Text via DOI: 10.1002/ehf2.12548 Web of Science: 000501822800001
- 2019
  
  P2750Why should cardiopulmonary exercise testing be routinely used for assessing patients with valvular heart disease?. EUROPEAN HEART JOURNAL. 40:ehz748.1067.
  Full Text via DOI: 10.1093/eurheartj/ehz748.1067
- 2019
  
  P5425Prognostic value of NYHA functional class in heart failure patients undergoing primary prevention implantable cardioverter defibrillator therapy. EUROPEAN HEART JOURNAL. 40:ehz746.0382.
  Full Text via DOI: 10.1093/eurheartj/ehz746.0382
- 2019
  
  P5680One-year outcomes of heart failure patients undergoing cardiac resynchronization therapy using adaptivCRT algorithm. EUROPEAN HEART JOURNAL. 40:ehz746.0622.
  Full Text via DOI: 10.1093/eurheartj/ehz746.0622
- 2019
  
  Highlight article: Ligand-independent activation of the P2X7 receptor by Hsp90 inhibition stimulates motor neuron apoptosis. EXPERIMENTAL BIOLOGY AND MEDICINE. 244:901-914.
  Full Text via DOI: 10.1177/1535370219853798 Web of Science: 000480264200006
- 2019
  
  Survival and arrhythmic risk among ischemic and non-ischemic heart failure patients with prophylactic implantable cardioverter defibrillator only therapy: A propensity score-matched analysis. INTERNATIONAL JOURNAL OF CARDIOLOGY. 274:163-169.
  Full Text via DOI: 10.1016/j.ijcard.2018.09.003 Web of Science: 000450293300034
- 2018
  
  P3453Survival and arrhythmic mortality among ischemic and non-ischemic heart failure patients undergoing ICD-only therapy for primary prevention strategy. EUROPEAN HEART JOURNAL. 39:ehy563.p3453.
  Full Text via DOI: 10.1093/eurheartj/ehy563.p3453
- 2017
  
  P1741Arrhythmic risk among ischemic and non-ischemic heart failure patients with narrow QRS: insigths from the umbrella registry
  Full Text via DOI: 10.1093/ehjci/eux161.051
- 2017
  
  P1744Inappropriate therapies in primary prevention ICD patients with narrow QRS: dual or single chamber ICD? The question remains
  Full Text via DOI: 10.1093/ehjci/eux161.054
- 2017
  
  Targeting Extracellular Cyclophilin A Reduces Neuroinflammation and Extends Survival in a Mouse Model of Amyotrophic Lateral Sclerosis. JOURNAL OF NEUROSCIENCE. 37:1413-1427.
  Full Text via DOI: 10.1523/JNEUROSCI.2462-16.2016 Web of Science: 000393572400004
- 2016
  
  Copper delivery to the CNS by CuATSM effectively treats motor neuron disease in SOD^G93A mice co-expressing the Copper-Chaperone-for-SOD
  Full Text via DOI: 10.1016/j.nbd.2016.01.020 Web of Science: 000372668100001
- 2015
  
  Chronic inhibitory effect of riluzole on trophic factor production. EXPERIMENTAL NEUROLOGY. 271:301-307.
  Full Text via DOI: 10.1016/j.expneurol.2015.05.016 Web of Science: 000362627200031
- 2015
  
  Nitration of Hsp90 on Tyrosine 33 Regulates Mitochondrial Metabolism
  Full Text via DOI: 10.1074/jbc.M115.663278 Web of Science: 000358781100023
- 2015
  
  Reactive nitrogen species in cellular signaling. EXPERIMENTAL BIOLOGY AND MEDICINE. 240:711-717.
  Full Text via DOI: 10.1177/1535370215581314 Web of Science: 000356007700003
- 2013
  
  Nitration of Hsp90 induces cell death. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 110:E1102-E1111.
  Full Text via DOI: 10.1073/pnas.1215177110 Web of Science: 000317521600006
- 2013
  
  Temporal patterns of tyrosine nitration in embryo heart development. FREE RADICAL BIOLOGY AND MEDICINE. 55:101-108.
  Full Text via DOI: 10.1016/j.freeradbiomed.2012.10.535 Web of Science: 000315009600012
- 2012
  
  Mitochondrial Dynamics and Bioenergetic Dysfunction Is Associated with Synaptic Alterations in Mutant SOD1 Motor Neurons. JOURNAL OF NEUROSCIENCE. 32:229-242.
  Full Text via DOI: 10.1523/JNEUROSCI.1233-11.2012 Web of Science: 000299119700022
- 2011
  
  Inactivation and Reactivation of the Mitochondrial α-Ketoglutarate Dehydrogenase Complex
  Full Text via DOI: 10.1074/jbc.M110.203018 Web of Science: 000290585200027
- 2010
  
  Cu, Zn-Superoxide Dismutase Increases Toxicity of Mutant and Zinc-deficient Superoxide Dismutase by Enhancing Protein Stability
  Full Text via DOI: 10.1074/jbc.M110.118901 Web of Science: 000283354000035
- 2009
  
  Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis. PLOS ONE. 4.
  Full Text via DOI: 10.1371/journal.pone.0008130 Web of Science: 000272828800022
- 2009
  
  gamma-Aminobutyric Acid-Mediated Regulation of the Activity-Dependent Olfactory Bulb Dopaminergic Phenotype
  Full Text via DOI: 10.1002/jnr.22055 Web of Science: 000267450700003
- 2009
  
  Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for multiple sclerosis. JOURNAL OF NEUROCHEMISTRY. 109:93-104.
  Full Text via DOI: 10.1111/j.1471-4159.2009.05891.x Web of Science: 000264022700009
- 2009
  
  Mitigation of peroxynitrite-mediated nitric oxide (NO) toxicity as a mechanism of induced adaptive NO resistance in the CNS. JOURNAL OF NEUROCHEMISTRY. 109:74-84.
  Full Text via DOI: 10.1111/j.1471-4159.2009.05884.x Web of Science: 000264022700007
- 2009
  
  Characteristics and Outcome of Angiographically Confirmed Stent Thrombosis
  Full Text via DOI: 10.1016/S0300-8932(09)70166-6 Web of Science: 000263316300013
- 2008
  
  Long-term Outcome of Infective Endocarditis in Non-Intravenous Drug Users. MAYO CLINIC PROCEEDINGS. 83:1213-1217.
  Full Text via DOI: 10.4065/83.11.1213 Web of Science: 000260743900004
- 2008
  
  Chest Pain in the Emergency Department: Incidence, Clinical Characteristics and Risk Stratification
  Full Text via DOI: 10.1016/S1885-5857(08)60256-X Web of Science: 000260006300009
- 2008
  
  Control of Muscle Mitochondria by Insulin Entails Activation of Akt2-mtNOS Pathway: Implications for the Metabolic Syndrome. PLOS ONE. 3.
  Full Text via DOI: 10.1371/journal.pone.0001749 Web of Science: 000260723000003
- 2007
  
  Mutant Cu/Zn-superoxide dismutase associated with amyotrophic lateral sclerosis destabilizes vascular endothelial growth factor mRNA and downregulates its expression. JOURNAL OF NEUROSCIENCE. 27:7929-7938.
  Full Text via DOI: 10.1523/JNEUROSCI.1877-07.2007 Web of Science: 000248484800006
- 2006
  
  Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells. CELL DEATH AND DIFFERENTIATION. 13:1506-1514.
  Full Text via DOI: 10.1038/sj.cdd.4401831 Web of Science: 000239920600009
- 2006
  
  Arginase 1 regulation of nitric oxide production is key to survival of trophic factor-deprived motor neurons. JOURNAL OF NEUROSCIENCE. 26:8512-8516.
  Full Text via DOI: 10.1523/JNEUROSCI.0728-06.2006 Web of Science: 000239817700011
- 2006
  
  Interactions between beta-neuregulin and neurotrophins in motor neuron apoptosis. JOURNAL OF NEUROCHEMISTRY. 97:222-233.
  Full Text via DOI: 10.1111/j.1471-4159.2006.03739.x Web of Science: 000235986000020
- 2006
  
  S-nitrosothiol depletion in amyotrophic lateral sclerosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 103:2404-2409.
  Full Text via DOI: 10.1073/pnas.0507243103 Web of Science: 000235411600072
- 2005
  
  A new risk score for patients with a normal or non-diagnostic ECG admitted to a chest pain unit
  Full Text via DOI: 10.1157/13077229 Web of Science: 000231652700005
- 2005
  
  Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis:: implications for amyotrophic lateral sclerosis. JOURNAL OF NEUROCHEMISTRY. 93:38-46.
  Full Text via DOI: 10.1111/j.1471-4159.2004.02984.x Web of Science: 000227533200004
- 2004
  
  Biosynthesis and catabolism of prostaglandin F-2(alpha) (PGF(2 alpha)) are controlled by progesterone in the rat uterus during pregnancy. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 91:211-218.
  Full Text via DOI: 10.1016/j.jsbmb.2004.05.001 Web of Science: 000224043500003
- 2004
  
  Induction of motor neuron apoptosis by free 3-nitro-L-tyrosine. JOURNAL OF NEUROCHEMISTRY. 89:602-612.
  Full Text via DOI: 10.1046/j.1471-4159.2004.02363.x Web of Science: 000220854900008
- 2004
  
  Astrocytic production of nerve growth factor in motor neuron apoptosis:: implications for amyotrophic lateral sclerosis. JOURNAL OF NEUROCHEMISTRY. 89:464-473.
  Full Text via DOI: 10.1111/j.1471-4159.2004.02357.x Web of Science: 000220545900018
- 2003
  
  Microtubule destabilization and nuclear entry are sequential steps leading to toxicity in Huntington's disease. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 100:12171-12176.
  Full Text via DOI: 10.1073/pnas.2034961100 Web of Science: 000186024300045
- 2002
  
  Ccs knockout mice establish an alternative source of copper for SOD in ALS. FREE RADICAL BIOLOGY AND MEDICINE. 33:1433-1435.
  Full Text via DOI: 10.1016/S0891-5849(02)01092-4 Web of Science: 000179128100015
- 2002
  
  Motoneuron death triggered by a specific pathway downstream of Fas:: Potentiation by ALS-linked SOD1 mutations. NEURON. 35:1067-1083.
  Full Text via DOI: 10.1016/S0896-6273(02)00905-4 Web of Science: 000178040000008
- 2002
  
  Cyclic guanosine 5 ' monophosphate (GMP) prevents expression of neuronal nitric oxide synthase and apoptosis in motor neurons deprived of trophic factors in rats
  Full Text via DOI: 10.1016/S0304-3940(02)00341-5 Web of Science: 000176976300014
- 2002
  
  Nitric oxide and superoxide, a deadly cocktail. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 962:207-211.
  Full Text via DOI: 10.1111/j.1749-6632.2002.tb04069.x Web of Science: 000176952400019
- 2002
  
  Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
  Full Text via DOI: 10.1002/jnr.10107 Web of Science: 000173098800003
- 2001
  
  Superoxide dismutase and the death of motoneurons in ALS. TRENDS IN NEUROSCIENCES. 24:15-20.
  Full Text via DOI: 10.1016/s0166-2236(01)00004-2
- 2000
  
  Hypercapnia induces injury to alveolar epithelial cells via a nitric oxide-dependent pathway. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 279:L994-L1002.
  Full Text via DOI: 10.1152/ajplung.2000.279.5.L994 Web of Science: 000090056200027
- 2000
  
  Liposome-delivered superoxide dismutase prevents nitric oxide-dependent motor neuron death induced by trophic factor withdrawal. FREE RADICAL BIOLOGY AND MEDICINE. 28:437-446.
  Full Text via DOI: 10.1016/S0891-5849(99)00261-0 Web of Science: 000085619000016
- 1999
  
  Induction of nitric oxide-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase. SCIENCE. 286:2498-2500.
  Full Text via DOI: 10.1126/science.286.5449.2498 Web of Science: 000084429700046
- 1999
  
  Microtubule dysfunction by posttranslational nitrotyrosination of α-tubulin:: A nitric oxide-dependent mechanism of cellular injury. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 96:6365-6370.
  Full Text via DOI: 10.1073/pnas.96.11.6365 Web of Science: 000080527100082
- 1999
  
  Binding of xanthine oxidase to vascular endothelium - Kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. JOURNAL OF BIOLOGICAL CHEMISTRY. 274:4985-4994.
  Full Text via DOI: 10.1074/jbc.274.8.4985 Web of Science: 000078698200068
- 1998
  
  Enhancement of peroxynitrite-induced apoptosis in PC12 cells by fibroblast growth factor-1 and nerve growth factor requires p21 Ras activation and is suppressed by Bcl-2. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 356:41-45.
  Full Text via DOI: 10.1006/abbi.1998.0741 Web of Science: 000075361800006
- 1998
  
  Nitric oxide-dependent production of cGMP supports the survival of rat embryonic motor neurons cultured with brain-derived neurotrophic factor. JOURNAL OF NEUROSCIENCE. 18:3708-3714.
  Web of Science: 000073484300022
- 1998
  
  Nitric oxide and superoxide contribute to motor neuron apoptosis induced by trophic factor deprivation. JOURNAL OF NEUROSCIENCE. 18:923-931.
  Web of Science: 000071620300013
- 1997
  
  Nerve growth factor protects PC12 cells against peroxynitrite-induced apoptosis via a mechanism dependent on phosphatidylinositol 3-kinase. JOURNAL OF NEUROCHEMISTRY. 69:53-59.
  Web of Science: A1997XF43100006
- 1997
  
  Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers
  Full Text via DOI: 10.1016/S0304-3940(97)00384-4 Web of Science: A1997XJ90100017
- 1995
  
  PEROXYNITRITE-INDUCED CYTOTOXICITY IN PC12 CELLS - EVIDENCE FOR AN APOPTOTIC MECHANISM DIFFERENTIALLY MODULATED BY NEUROTROPHIC FACTORS. JOURNAL OF NEUROCHEMISTRY. 65:1543-1550.
  Web of Science: A1995RW33500013
- 1995
  
  PROTECTIVE EFFECT OF RILUZOLE ON EXCITATORY AMINO ACID-MEDIATED NEUROTOXICITY IN MOTONEURON-ENRICHED CULTURES. EUROPEAN JOURNAL OF PHARMACOLOGY. 280:47-53.
  Full Text via DOI: 10.1016/0014-2999(95)00186-O Web of Science: A1995RF67300006
- 1992
  
  EFFECT OF FOLLICLE-STIMULATING-HORMONE ON INSULIN-LIKE GROWTH FACTOR-I-STIMULATED RAT GRANULOSA-CELL DEOXYRIBONUCLEIC-ACID SYNTHESIS. ENDOCRINOLOGY. 131:1223-1229.
  Full Text via DOI: 10.1210/en.131.3.1223 Web of Science: A1992JK94500032
- 1992
  
  Effect of follicle-stimulating hormone on insulin-like growth factor-I-stimulated rat granulosa cell deoxyribonucleic acid synthesis. ENDOCRINOLOGY. 131:1223-1229.
- 1991
  
  TUNICAMYCIN INHIBITS THE INITIATION OF DNA-SYNTHESIS STIMULATED BY PROSTAGLANDIN-F2-ALPHA IN SWISS MOUSE 3T3 CELLS. FEBS LETTERS. 290:239-242.
  Full Text via DOI: 10.1016/0014-5793(91)81269-E Web of Science: A1991GJ55300059
- 1990
  
  Role of dolichol in the control of DNA replication in swiss mouse 3T3 cells
  Full Text via DOI: 10.1016/0309-1651(90)90610-b
- 1989
  
  GABA AND ITS NEURAL REGULATION IN RAT BROWN ADIPOSE-TISSUE. JOURNAL OF NEURAL TRANSMISSION. 78:17-28.
  Full Text via DOI: 10.1007/BF01247110 Web of Science: A1989AP68100003
- 1989
  
  TIME-DEPENDENT EFFECT OF MELATONIN ON GLUTAMIC-ACID DECARBOXYLASE ACTIVITY AND CL-36(-) INFLUX IN RAT HYPOTHALAMUS
  Full Text via DOI: 10.1111/j.1365-2826.1989.tb00145.x Web of Science: A1989CJ72000011
- 1988
  
  BENZODIAZEPINE BINDING-SITES IN RAT INTERSCAPULAR BROWN ADIPOSE-TISSUE - EFFECT OF COLD ENVIRONMENT, DENERVATION AND ENDOCRINE ABLATIONS. LIFE SCIENCES. 42:393-402.
  Full Text via DOI: 10.1016/0024-3205(88)90077-X Web of Science: A1988L393300006
- 1987
  
  NORMAL SERUM-PROTEINS IN FEMALE BREAST CARCINOMAS AND FIBROADENOMAS - AN IMMUNOHISTOCHEMICAL STUDY
  Web of Science: A1987L235700007
- 1977
  
  SERUM IMMUNOGLOBULIN A CHANGES IN ALCOHOLIC PATIENTS
  Web of Science: A1977DE84700008
- LAPAROSCOPIC ADNEXECTOMY OF A GONADOBLASTOMA
  Full Text via DOI: 10.1089/gyn.1992.8.87 Web of Science: A1992JL29100008
- Stimulation of nerve growth factor expression in astrocytes by peroxynitrite
  Web of Science: 000222954800002
- Triterpenoid and phenolic compounds from two Chilean Celastraceae
  Web of Science: 000078985000022
Book
- 1999
  
  Examining apoptosis in cultured cells after exposure to nitric oxide and peroxynitrite. Ed. 301.
  Web of Science: 000079435000041
- 1999
  
  Immunohistochemical methods to detect nitrotyrosine. Ed. 301.
  Web of Science: 000079435000039
- 1998
  
  Role of endogenous nitric oxide and peroxynitrite formation in the survival and death of motor neurons in culture. Ed. 118.
  Web of Science: 000079831200019
Book Chapter
- 2016
  
  Amyotrophic Lateral Sclerosis: Present Understanding of the Role of SOD. 597-603.
  Full Text via DOI: 10.1007/978-3-319-30705-3_26 Web of Science: 000403568200028
- 2013
  
  Pathophysiology of Amyotrophic Lateral Sclerosis
  Full Text via DOI: 10.5772/56562
- 2013
  
  Superoxide Dismutase and Oxidative Stress in Amyotrophic Lateral Sclerosis
  Full Text via DOI: 10.5772/56488
- 2011
  
  Reactive Nitrogen Species in Motor Neuron Apoptosis. 313-334.
  Web of Science: 000430535700014
- 2002
  
  Peroxynitrite and injury to the vasculature and central nervous system in stroke and neurodegeneration. 23-46.
  Full Text via DOI: 10.1017/cbo9780511544910.004
- 2001
  
  Roles for Fas in Programmed Cell Death of Motoneurons. 33-45.
  Full Text via DOI: 10.1007/978-3-662-04333-2_4
- 2000
  
  Nitric Oxide Toxicity in Neuronal Injury and Degeneration. 262-278.
  Full Text via DOI: 10.1007/978-1-4612-1328-4_12
- 1997
  
  Peroxynitrite and Cell Signaling. 32-51.
  Full Text via DOI: 10.1007/978-1-4615-5981-8_2
- 1993
  
  CONCERTED MITOGENIC SIGNALS CONTROL MAMMALIAN DNA-REPLICATION PROTEIN-KINASE-C ROLE. 213-218.
  Web of Science: A1993BX34U00043
Conference
- 2021
  
  Single- vs dual-chamber ICDs to prevent from inappropriate shocks: the debate is still alive. EUROPEAN HEART JOURNAL. 686-686.
  Web of Science: 000720456900657
- 2021
  
  Validation of leadless atrioventricular synchronous pacing with Holter-ECG: a pilot study. EUROPEAN HEART JOURNAL. 674-674.
  Web of Science: 000720456900644
- 2020
  
  Apoptotic Signaling Pathways Activated by Peroxynitrite-Mediated Nitration. FREE RADICAL BIOLOGY AND MEDICINE. S13-S13.
  Full Text via DOI: 10.1016/j.freeradbiomed.2020.10.050 Web of Science: 000590930700021
- 2019
  
  A Biochemical and Biophysical Investigation into the Pathological Gain -of-Function of Nitrated Hsp90. FREE RADICAL BIOLOGY AND MEDICINE. S29-S29.
  Full Text via DOI: 10.1016./j.freeradbiomed.2019.10.072 Web of Science: 000496777400059
- 2019
  
  Nitrated Hsp90 Mediates Peroxynitrite-Induced Apoptosis. FREE RADICAL BIOLOGY AND MEDICINE. S102-S102.
  Full Text via DOI: 10.1016/j.freeradbiomed.2019.10.273 Web of Science: 000496777400254
- 2018
  
  RISK OF LIFE-THREATENING ARRHYTHMIC EVENTS IN NON-ISCHEMIC HEART FAILURE PATIENTS WITH PROPHYLACTIC CARDIOVERTER DEFIBRILLATOR. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 485-485.
  Full Text via DOI: 10.1016/S0735-1097(18)31026-X Web of Science: 000429659701335
- 2013
  
  ALS and the role of zinc and copper bound to superoxide dismutase. JOURNAL OF NEUROCHEMISTRY. 61-61.
  Web of Science: 000316961700116
- 2011
  
  NITRATED HSP90 DECREASES MITOCHONDRIAL MEMBRANE POTENTIAL AND OXYGEN CONSUMPTION. JOURNAL OF NEUROCHEMISTRY. 153-153.
  Web of Science: 000431628300386
- 2011
  
  NITRATED HSP90 INDUCES APOPTOSIS IN MOTOR NEURONS BY A FAS-DEPENDENT MECHANISM. JOURNAL OF NEUROCHEMISTRY. 211-211.
  Web of Science: 000431628300523
- 2009
  
  Nitration of a Single HSP90 Tyrosine Residue is Sufficient to Induce Cell Death. FREE RADICAL BIOLOGY AND MEDICINE. S74-S75.
  Web of Science: 000271988500210
- 2007
  
  Indications, description, and results or percutaneous transcatheter repairs of mitral paravalvular regurgitations. AMERICAN JOURNAL OF CARDIOLOGY. 59L-59L.
  Web of Science: 000250393900129
- 2007
  
  Infective endocarditis in non intravenous drug users: determinants of long term survival after discharge. 439-440.
  Web of Science: 000246617500114
- 2007
  
  Induction therapy in heart transplantation: A comparison between two-dose daclizumab and antithymocyte globulin therapy.. AMERICAN JOURNAL OF TRANSPLANTATION. 425-425.
  Web of Science: 000246370201518
- 2007
  
  ALS-associated Cu/Zn SOD mutant protein is linked to VEGF mRNA destabilization and down-regulation in vitro. NEUROLOGY. A244-A245.
  Web of Science: 000245175001467
- 2006
  
  Arginase 1 prevents the death of trophic deprived motor neurons by inhibiting nitric oxide production. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. A67-A67.
  Full Text via DOI: 10.1016/j.niox.2006.04.219 Web of Science: 000238400500207
- 2006
  
  Temporal expression profiles of vascular endothelial growth factor and inducible nitric oxide synthase in a transgenic mouse of amyotrophic lateral sclerosis. NEUROLOGY. A137-A137.
  Web of Science: 000236068101214
- 2004
  
  A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis. 263-274.
  Full Text via DOI: 10.1016/j.brainresrev.2004.05.003 Web of Science: 000229308600019
- 2004
  
  Nitric oxide renders motor neurons vulnerable to p75NTR mediated apoptosis. FREE RADICAL BIOLOGY AND MEDICINE. S104-S104.
  Web of Science: 000221320200272
- 2003
  
  Peroxynitrite formation by zinc-deficient superoxide dismutase. FREE RADICAL BIOLOGY AND MEDICINE. S22-S22.
  Web of Science: 000186658900055
- 2002
  
  Superoxide dismutase and motor neuron death in ALS. FREE RADICAL BIOLOGY AND MEDICINE. S304-S304.
  Web of Science: 000179199600015
- 2001
  
  Zinc-deficient superoxide dismutase: A possible mechanism for ALS. 79-86.
  Web of Science: 000172402700011
- 2000
  
  Neuregulin supports the survival of embryonic rat spinal cord motor neurons.. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 458-458.
  Web of Science: 000086871100166
- 1999
  
  Interactions between peroxynitrite and trophic support in apoptosis and cell survival. 243-249.
  Web of Science: 000082191900024
- 1998
  
  Peroxynitrite and superoxide dismutase in amyotrophic lateral sclerosis.. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. U572-U572.
  Web of Science: 000075234901662
- 1998
  
  Post-translational nitrotyrosination of alpha-tubulin: A nitric oxide dependent mechanism of cytoskeletal dysfunction in inflammation. FREE RADICAL BIOLOGY AND MEDICINE. S59-S59.
  Web of Science: 000077051400172
- 1998
  
  Post-translational nitrotyrosination of alpha-tubulin: A nitric oxide-dependent mechanism of cytoskeletal dysfunction in inflammation. FREE RADICAL BIOLOGY AND MEDICINE. S45-S45.
  Web of Science: 000077051400127
- 1998
  
  SOD and ALS: Loss of zinc makes SOD toxic to motor neurons. FREE RADICAL BIOLOGY AND MEDICINE. S110-S110.
  Web of Science: 000077051400332
Letter
- 2010
  
  Chest Pain With an Elevated Troponin Level but Without Significant Coronary Artery Disease Is Not Usually Due to an Infarction. 371-372.
  Full Text via DOI: 10.1016/S0300-8932(10)70103-2 Web of Science: 000275721300021
- 2009
  
  The CPU-65 Risk Index: Validation and Clinical Value Response. 228-228.
  Full Text via DOI: 10.1016/S0300-8932(09)70170-8 Web of Science: 000263316300017
Other Scholarly Work
- 2022
  
  Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells (vol 13, pg 1506, 2006). CELL DEATH AND DIFFERENTIATION. 2563-2563.
  Full Text via DOI: 10.1038/s41418-022-01056-2 Web of Science: 000850773800001
- 2022
  
  Establishing Nitrated Hsp90 Cellular Interactome. FREE RADICAL BIOLOGY AND MEDICINE.
  Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.259 Web of Science: 000895512500272
- 2022
  
  Nitrated Hsp90 Supports Glioblastoma Multiforme Cell Survival by Maintaining P2X7 Receptor Activation. FREE RADICAL BIOLOGY AND MEDICINE.
  Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.200 Web of Science: 000895512500212
- 2022
  
  Site-Specific Nitration of Hsp90 Alters Cell Metabolism and Supports Schwannoma Cell Proliferation. FREE RADICAL BIOLOGY AND MEDICINE.
  Full Text via DOI: 10.1016/j.freeradbiomed.2022.10.190 Web of Science: 000895512500202
- 2022
  
  A Computational Method to Visualize Nitrated Hsp90 Distribution in 3D Culture Models. FREE RADICAL BIOLOGY AND MEDICINE. 36-36.
  Full Text via DOI: 10.1016/j.freeradbiomed.2021.12.073 Web of Science: 000778588700059
- 2022
  
  Nitrated Hsp90 Regulates Glioblastoma Multiforme Proliferation and Migration. FREE RADICAL BIOLOGY AND MEDICINE. 34-34.
  Full Text via DOI: 10.1016/j.freeradbiomed.2021.12.068 Web of Science: 000778588700054
- 2022
  
  Nitration of Heat Shock Protein 90 Affects its Spatial Distribution and Promotes the Survival/Proliferation of Schwannoma Cells. FREE RADICAL BIOLOGY AND MEDICINE. 32-32.
  Full Text via DOI: 10.1016/j.freeradbiomed.2021.12.064 Web of Science: 000778588700050
- 2022
  
  A Computational Method for the Visualization of Nitrated Hsp90 Distribution in 3D Culture Models. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fasebj.2022.36.S1.R5066 Web of Science: 000878430605454
- 2022
  
  Nitrated Hsp90 Supports Glioblastoma Multiforme Cell Survival and Migration. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fasebj.2022.36.S1.R3822 Web of Science: 000878430604075
- 2022
  
  Nitration of Hsp90 Affects its Spatial Distribution and Promotes Schwannoma Cell Proliferation. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fasebj.2022.36.S1.R4036 Web of Science: 000878430604269
- 2022
  
  Structural Changes Induced in Hsp90 by Nitration lead to a Pathological Gain-of-function. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fasebj.2022.36.S1.R5745 Web of Science: 000878430606326
- 2021
  
  Tyrosine Nitration Supports Gliobastoma Multiforme Cell Survival and Regulates Migration. FASEB JOURNAL.
  Full Text via DOI: 10.1096/fasebj.2021.35.S1.02940 Web of Science: 000669893102349
- 2020
  
  Impact of an adaptive CRT optimization algorithm on the risk of life-threatening ventricular arrythmias of heart failure patients. EUROPEAN HEART JOURNAL. 763-763.
  Web of Science: 000606106300763
- 2020
  
  Tyrosine Nitration Supports Glioblastoma Multiforme Cell Survival and Regulates Migration. FREE RADICAL BIOLOGY AND MEDICINE. S59-S59.
  Full Text via DOI: 10.1016/j.freeradbiomed.2020.10.158 Web of Science: 000590930700126
- 2014
  
  Nitrated Hsp90-induced PC12 cell apoptosis requires p38 and JINK MAP kinase activation. NITRIC OXIDE-BIOLOGY AND CHEMISTRY. 135-135.
  Full Text via DOI: 10.1016/j.niox.2014.09.108 Web of Science: 000345812900115
- 2014
  
  Site-Specific Nitrated Hsp90 Is a Target for Drug Development in Cancer. FREE RADICAL BIOLOGY AND MEDICINE. S125-S125.
  Full Text via DOI: 10.1016/j.freeradbiomed.2014.10.191 Web of Science: 000359525800314
- 2012
  
  Nitrated Hsp90 Regulates Mitochondrial Membrane Potential and Oxygen Consumption in Cancer Cells. FREE RADICAL BIOLOGY AND MEDICINE. S42-S43.
  Full Text via DOI: 10.1016/j.freeradbiomed.2012.10.110 Web of Science: 000310660600104
- 2011
  
  Nitrated Hsp90 Decreases Mitochondrial Membrane Potential and Oxygen Consumption. FREE RADICAL BIOLOGY AND MEDICINE. S28-S28.
  Full Text via DOI: 10.1016/j.freeradbiomed.2011.10.065 Web of Science: 000297036600059
- 2011
  
  Nitrated Hsp90 Induces Apoptosis in Motor Neurons by a Fas-Dependent Mechanism. FREE RADICAL BIOLOGY AND MEDICINE. S28-S28.
  Full Text via DOI: 10.1016/j.freeradbiomed.2011.10.066 Web of Science: 000297036600060
- 2008
  
  Positive non-invasive tests in the chest pain unit: importance of the clinical profile for estimating the probability of coronary artery disease.. 205-208.
  Full Text via DOI: 10.1080/17482940701805408
- 2007
  
  Good science shows the way - Highlight Commentary on "Redox proteomics analysis of oxidatively modified proteins in G93A-SOD1 transgenic mice - A model of familial amyotrophic lateral sclerosis". FREE RADICAL BIOLOGY AND MEDICINE. 163-164.
  Full Text via DOI: 10.1016/j.freeradbiomed.2007.04.011 Web of Science: 000248012400003
Review
- 2017
  
  Permanent Cerebellar Degeneration After Acute Hyperthermia with Non-toxic Lithium Levels: a Case Report and Review of Literature. 973-978.
  Full Text via DOI: 10.1007/s12311-017-0868-3 Web of Science: 000417196600011
- 2017
  
  Cellular mechanisms of peroxynitrite-induced neuronal death. BRAIN RESEARCH BULLETIN. 4-11.
  Full Text via DOI: 10.1016/j.brainresbull.2017.05.008 Web of Science: 000410869700002
- 2014
  
  Tyrosine nitration as mediator of cell death. CELLULAR AND MOLECULAR LIFE SCIENCES. 3939-3950.
  Full Text via DOI: 10.1007/s00018-014-1662-8 Web of Science: 000342420300005
- 2012
  
  Nitric Oxide-Mediated Oxidative Damage and the Progressive Demise of Motor Neurons in ALS. 251-264.
  Full Text via DOI: 10.1007/s12640-012-9322-y Web of Science: 000308966400001
- 2007
  
  Harnessing hypoxic adaptation to prevent, treat, and repair stroke. JOURNAL OF MOLECULAR MEDICINE-JMM. 1331-1338.
  Full Text via DOI: 10.1007/s00109-007-0283-1 Web of Science: 000251487500008
- 2007
  
  Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides. 6324-6337.
  Full Text via DOI: 10.1074/jbc.M610800200 Web of Science: 000244867200039
- 2001
  
  Superoxide dismutase and the death of motoneurons in ALS. TRENDS IN NEUROSCIENCES. S15-S20.
  Full Text via DOI: 10.1016/S0166-2236(00)01981-0 Web of Science: 000172144400004
- 2000
  
  Nitric oxide and peroxynitrite in the perinatal period. 37-41.
  Full Text via DOI: 10.1016/S0146-0005(00)80053-1 Web of Science: 000085552400010

full name

Alvaro Estevez

ORCID iD

https://orcid.org/0000-0003-2671-3773 (confirmed)

visualizations

Co-author Network