Overview
biography
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Jerry Edward Chipuk's research centers on understanding how mitochondrial biology influences cancer development and progression, with a particular focus on melanoma and hematologic malignancies. In his role as chair of Cellular and Molecular Medicine, he aims to strengthen the collegeâs research infrastructure and expand collaborations with clinical partners to help accelerate the translation of scientific discoveries into real-world patient care.
Before joining FIU in 2026, Chipuk was a tenured professor of oncological sciences and dermatology at the Icahn School of Medicine at Mount Sinai and associate director of the National Cancer Institute-designated Mount Sinai Tisch Cancer Center.
Chipuk has authored more than 100 peer-reviewed publications, maintained National Institutes of Health funding and mentored dozens of trainees at multiple career stages. He has also established interdisciplinary collaborations that connect basic science discoveries with clinical and translational research.
research interests
- Mitochondrial Biology; Regulated Cell Death; Oncogenic Signaling; Cellular Metabolism; Cancer Mechanisms
Scholarly & Creative Works
selected scholarly works & creative activities
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Article
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2026LGBTQ plus Realities in the Biological Sciences. CBE Life Sciences Education. 25.Full Text via DOI: 10.1187/cbe.25-05-0098 Web of Science: 001824028900001
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2026A peptide-based screen for cell death inhibitors identifies the cytoprotective compound CDL36.. bioRxiv.Full Text via DOI: 10.64898/2026.07.09.737573
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2026A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAFV600E-Associated Mitochondrial Division in Cancer. Antibodies. 15.Full Text via DOI: 10.3390/antib15020038 Web of Science: 001749200100001
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2026Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia. CANCER DISCOVERY. 16:541-570.Full Text via DOI: 10.1158/2159-8290.CD-25-0556 Web of Science: 001707099800002
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2026A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function. NATURE COMMUNICATIONS. 17.Full Text via DOI: 10.1038/s41467-026-69836-9 Web of Science: 001732583400013
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2026Utilizing FLAMBE to study the structure-function relationship and regulation of monomeric BAX activation in solution. Methods in Cell Biology. 209:1-26.Full Text via DOI: 10.1016/bs.mcb.2026.04.007
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2025Resolvin D1-mediated cellular crosstalk protects against MASH. JHEP Reports. 7.Full Text via DOI: 10.1016/j.jhepr.2025.101454 Web of Science: 001533825400001
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2025Bone-Induced HER2 Promotes Secondary Metastasis in HR+/HER2- Breast Cancer. CANCER DISCOVERY. 15:818-837.Full Text via DOI: 10.1158/2159-8290.CD-23-0543 Web of Science: 001458212100009
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2025Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.. bioRxiv.Full Text via DOI: 10.1101/2025.03.19.643917
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2025Harnessing the TAF1 Acetyltransferase for Targeted Acetylation of the Tumor Suppressor p53. Advanced Science. 12.Full Text via DOI: 10.1002/advs.202413377 Web of Science: 001381985600001
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2025Metabolic adaptations to acute glucose uptake inhibition converge upon mitochondrial respiration for leukemia cell survival. Cell Communication and Signaling. 23.Full Text via DOI: 10.1186/s12964-025-02044-y Web of Science: 001405617200002
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2024A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function.. bioRxiv.Full Text via DOI: 10.1101/2024.12.23.630122
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2024606 The BRAFV600E induced mitochondrial unfolded protein response informs the melanoma immune landscape and patient survival. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 144:s105.Full Text via DOI: 10.1016/j.jid.2024.06.622
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2024S1PR1 inhibition induces proapoptotic signaling in T cells and limits humoral responses within lymph nodes. Journal of Clinical Investigation. 134.Full Text via DOI: 10.1172/JCI174984 Web of Science: 001178388500028
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2023An optimized protocol for expression and purification of monomeric full-length BAX protein for functional interrogations. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 11.Full Text via DOI: 10.3389/fcell.2023.1322816 Web of Science: 001130237400001
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2023Sustained CD28 costimulation is required for self-renewal and differentiation of TCF-1+ PD-1+ CD8 T cells. Science Immunology. 8.Full Text via DOI: 10.1126/sciimmunol.adg0878 Web of Science: 001161704400001
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2022IFN-γ+ cytotoxic CD4+ T lymphocytes are involved in the pathogenesis of colitis induced by IL-23 and the food colorant Red 40. CELLULAR & MOLECULAR IMMUNOLOGY. 19:777-790.Full Text via DOI: 10.1038/s41423-022-00864-3 Web of Science: 000787133200001
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2022FLAMBE: A kinetic fluorescence polarization assay to study activation of monomeric BAX. STAR Protocols. 3.Full Text via DOI: 10.1016/j.xpro.2022.101252 Web of Science: 001062208700010
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2022Abstract 3613: CD28 signaling controls maintenance and differentiation of PD1+CD8 T cells during chronic antigen stimulation. CANCER RESEARCH. 82:3613-3613.Full Text via DOI: 10.1158/1538-7445.am2022-3613
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2022PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes. Cell Stem Cell. 29:559-+.Full Text via DOI: 10.1016/j.stem.2022.02.011 Web of Science: 000789475900010
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2022A kinetic fluorescence polarization ligand assay for monitoring BAX early activation. CELL REPORTS METHODS. 2.Full Text via DOI: 10.1016/j.crmeth.2022.100174 Web of Science: 000907653200001
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2021T cell-derived tumor necrosis factor induces cytotoxicity by activating RIPK1-dependent target cell death. JCI insight. 6.Full Text via DOI: 10.1172/jci.insight.148643 Web of Science: 000735237900001
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2021Mitochondrial localization and moderated activity are key to murine erythroid enucleation. BLOOD ADVANCES. 5:2490-2504.Full Text via DOI: 10.1182/bloodadvances.2021004259 Web of Science: 000656052200005
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2020Repeated hypoglycemia remodels neural inputs and disrupts mitochondrial function to blunt glucose-inhibited GHRH neuron responsiveness. JCI insight. 5.Full Text via DOI: 10.1172/jci.insight.133488 Web of Science: 000588434700002
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2020High-Throughput Cell Death Assays with Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling (SPARKL). STAR Protocols. 1.Full Text via DOI: 10.1016/j.xpro.2020.100034 Web of Science: 001050052600015
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2020Cell death through the ages: The ICDS 25th Anniversary Meeting. The FEBS Journal. 287:2201-2211.Full Text via DOI: 10.1111/febs.15252 Web of Science: 000536656600004
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2020Why not add some SPARKL to your life (and death)!?. Molecular and Cellular Oncology. 7.Full Text via DOI: 10.1080/23723556.2019.1685841 Web of Science: 000497348500001
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2019Single-Cell and Population-Level Analyses Using Real-Time Kinetic Labeling Couples Proliferation and Cell Death Mechanisms. DEVELOPMENTAL CELL. 51:277-+.Full Text via DOI: 10.1016/j.devcel.2019.08.016 Web of Science: 000491237500012
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2019Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool. Cell. 178:1102-+.Full Text via DOI: 10.1016/j.cell.2019.07.050 Web of Science: 000482191000009
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2019MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network. Molecular Cell. 74:452-+.Full Text via DOI: 10.1016/j.molcel.2019.02.012 Web of Science: 000466703900007
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2019Mitochondrial origins of fractional control in regulated cell death. NATURE COMMUNICATIONS. 10.Full Text via DOI: 10.1038/s41467-019-09275-x Web of Science: 000461881700018
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2019Late-onset megaconial myopathy in mice lacking group I Paks. Skeletal Muscle. 9.Full Text via DOI: 10.1186/s13395-019-0191-4 Web of Science: 000459427600001
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2019Aging of Antiviral CD8+ Memory T Cells Fosters Increased Survival, Metabolic Adaptations, and Lymphoid Tissue Homing. JOURNAL OF IMMUNOLOGY. 202:460-475.Full Text via DOI: 10.4049/jimmunol.1801277 Web of Science: 000455041800017
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2019Complex I and MDM2: hit me baby one more time. Molecular and Cellular Oncology. 6.Full Text via DOI: 10.1080/23723556.2019.1607457 Web of Science: 000471962100009
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2019Mitochondrial Isolation and Real-Time Monitoring of MOMP. Methods in molecular biology (Clifton, N.J.). 1877:121-130.Full Text via DOI: 10.1007/978-1-4939-8861-7_8 Web of Science: 000696321900009
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2018FBXW7 regulates a mitochondrial transcription program by modulating MITF. Pigment Cell and Melanoma Research. 31:636-640.Full Text via DOI: 10.1111/pcmr.12704 Web of Science: 000441249700009
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2018Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. Diabetes. 67:1561-1575.Full Text via DOI: 10.2337/db17-0943 Web of Science: 000439347300011
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2018Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition. Cell Death and Disease. 9.Full Text via DOI: 10.1038/s41419-017-0044-1 Web of Science: 000427452800001
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2018RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions. Journal of Experimental Medicine (JEM). 215:319-336.Full Text via DOI: 10.1084/jem.20161881 Web of Science: 000419134400023
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2017Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis. Oncogene. 36:4393-4404.Full Text via DOI: 10.1038/onc.2017.52 Web of Science: 000406806000002
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2017Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition. Journal of Biological Chemistry. 292:11727-11739.Full Text via DOI: 10.1074/jbc.M117.786442 Web of Science: 000405485600012
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2017Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells. NATURE. 546:158-+.Full Text via DOI: 10.1038/nature22352 Web of Science: 000402372800048
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2017Mitochondrial Fission in Human Diseases. Handbook of Experimental Pharmacology. 240:159-188.Full Text via DOI: 10.1007/164_2016_38 Web of Science: 000456457300008
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2016Robust high-throughput kinetic analysis of apoptosis with real-time high-content live-cell imaging. Cell Death and Disease. 7.Full Text via DOI: 10.1038/cddis.2016.332 Web of Science: 000391815800001
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2016Mouse Liver Mitochondria Isolation, Size Fractionation, and Real-time MOMP Measurement.. Bio-protocol. 6:e1892.Full Text via DOI: 10.21769/bioprotoc.1892
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2016From zero to sixty: cell death signaling in the city that never sleeps. Oncogene. 35:1457-1460.Full Text via DOI: 10.1038/onc.2015.194 Web of Science: 000372196400011
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2015Immune biomarkers are more accurate in prediction of survival in ulcerated than in non-ulcerated primary melanomas. Cancer Immunology, Immunotherapy. 64:1193-1203.Full Text via DOI: 10.1007/s00262-015-1726-0 Web of Science: 000359819400012
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2015Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3. EMBO Reports. 16:1164-1176.Full Text via DOI: 10.15252/embr.201439704 Web of Science: 000360716200013
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2015Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis. Molecular Cell. 59:677-684.Full Text via DOI: 10.1016/j.molcel.2015.06.029 Web of Science: 000362457900017
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2015Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance. Oncogene. 34:857-867.Full Text via DOI: 10.1038/onc.2014.21 Web of Science: 000349472000006
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2015Mitochondrial Division Is Requisite to RAS-Induced Transformation and Targeted by Oncogenic MAPK Pathway Inhibitors. Molecular Cell. 57:521-536.Full Text via DOI: 10.1016/j.molcel.2015.01.003 Web of Science: 000349550700014
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2015Mitochondrial Shape Governs BAX-Induced Membrane Permeabilization and Apoptosis. Molecular Cell. 57:69-82.Full Text via DOI: 10.1016/j.molcel.2014.10.028 Web of Science: 000347711100007
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2014B Cell Lymphoma-2 (BCL-2) Homology Domain 3 (BH3) Mimetics Demonstrate Differential Activities Dependent upon the Functional Repertoire of Pro-and Anti-apoptotic BCL-2 Family Proteins. Journal of Biological Chemistry. 289:26481-26491.Full Text via DOI: 10.1074/jbc.M114.569632 Web of Science: 000342128800039
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2014Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 111:8434-8439.Full Text via DOI: 10.1073/pnas.1407849111 Web of Science: 000336976000045
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2014Preclinical Pharmacological Evaluation of a Novel Multiple Kinase Inhibitor, ON123300, in Brain Tumor Models. MOLECULAR CANCER THERAPEUTICS. 13:1105-1116.Full Text via DOI: 10.1158/1535-7163.MCT-13-0847 Web of Science: 000335961600008
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2014Inducible Nitric Oxide Synthase Drives mTOR Pathway Activation and Proliferation of Human Melanoma by Reversible Nitrosylation of TSC2. CANCER RESEARCH. 74:1067-1078.Full Text via DOI: 10.1158/0008-5472.CAN-13-0588 Web of Science: 000331876600008
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2014How do I kill thee? Let me count the ways: p53 regulates PARP-1 dependent necrosis. BioEssays. 36:46-51.Full Text via DOI: 10.1002/bies.201300117 Web of Science: 000328391600009
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2013BAK/BAX activation and cytochrome c release assays using isolated mitochondria. Methods. 61:146-155.Full Text via DOI: 10.1016/j.ymeth.2013.03.030 Web of Science: 000321234700009
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2013BAK activation is necessary and sufficient to drive ceramide synthase-dependent ceramide accumulation following inhibition of BCL2-like proteins. BIOCHEMICAL JOURNAL. 452:111-119.Full Text via DOI: 10.1042/BJ20130147 Web of Science: 000318455700011
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2013Inter-organellar communication with mitochondria regulates both the intrinsic and extrinsic pathways of apoptosis.. Communicative and Integrative Biology. 6:e22872.Full Text via DOI: 10.4161/cib.22872
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2013PUMA binding induces partial unfolding within BCL-xL to disrupt p53 binding and promote apoptosis. Nature Chemical Biology. 9:163-168.Full Text via DOI: 10.1038/NCHEMBIO.1166 Web of Science: 000315132900011
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2013Survival of HER2-Positive Breast Cancer Cells: Receptor Signaling to Apoptotic Control Centers. Genes and Cancer. 4:187-195.Full Text via DOI: 10.1177/1947601913488598
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2013Getting away with murder: how does the BCL-2 family of proteins kill with immunity?. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 1285:59-79.Full Text via DOI: 10.1111/nyas.12045 Web of Science: 000324886100006
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2012Sensitization to the mitochondrial pathway of apoptosis augments melanoma tumor cell responses to conventional chemotherapeutic regimens. Cell Death and Disease. 3.Full Text via DOI: 10.1038/cddis.2012.161 Web of Science: 000311832600004
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2012Examining BCL-2 Family Function with Large Unilamellar Vesicles. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/4291-v
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2012Examining BCL-2 Family Function with Large Unilamellar Vesicles. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS.Full Text via DOI: 10.3791/4291 Web of Science: 000209225700038
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2012GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells. Immunity. 36:1031-1046.Full Text via DOI: 10.1016/j.immuni.2012.03.027 Web of Science: 000306097100019
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2012Genetically defining the mechanism of Puma- and Bim-induced apoptosis. Cell Death and Differentiation. 19:642-649.Full Text via DOI: 10.1038/cdd.2011.136 Web of Science: 000301374100010
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2012Sphingolipid Metabolism Cooperates with BAK and BAX to Promote the Mitochondrial Pathway of Apoptosis. Cell. 148:988-1000.Full Text via DOI: 10.1016/j.cell.2012.01.038 Web of Science: 000300985000018
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2011BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak. Journal of Biological Chemistry. 286:491-501.Full Text via DOI: 10.1074/jbc.M110.167148 Web of Science: 000285782800052
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2010PB1-F2 Proteins from H5N1 and 20th Century Pandemic Influenza Viruses Cause Immunopathology. PLOS PATHOGENS. 6.Full Text via DOI: 10.1371/journal.ppat.1001014 Web of Science: 000280527000042
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2010OR6,36 Characterization of a putative ‘BH3-like’ domain establishes IGFBP-3 as a unique intrinsic pathway activator that integrates cell survival and death signals in the mitochondrial regulatory network. Growth Hormone and IGF Research. 20:s16.Full Text via DOI: 10.1016/s1096-6374(10)70046-0
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2009PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis. Cell Cycle. 8:2692-2696.Full Text via DOI: 10.4161/cc.8.17.9412 Web of Science: 000269795800012
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2009Mitochondrial Outer Membrane Proteins Assist Bid in Bax-mediated Lipidic Pore Formation. MOLECULAR BIOLOGY OF THE CELL. 20:2276-2285.Full Text via DOI: 10.1091/mbc.E08-10-1056 Web of Science: 000265161400013
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2008Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 105:20327-20332.Full Text via DOI: 10.1073/pnas.0808036105 Web of Science: 000261995600057
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2008Chemical inhibition of the mitochondrial division dynamin reveals its role in Bax/Bak-dependent mitochondrial outer membrane permeabilization. DEVELOPMENTAL CELL. 14:193-204.Full Text via DOI: 10.1016/j.devcel.2007.11.019 Web of Science: 000253241400009
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2008Response to Callus et al on 'Cytoplasmic p53 is not required for PUMA-induced apoptosis'. Cell Death and Differentiation. 15:215-216.Full Text via DOI: 10.1038/sj.cdd.4402248 Web of Science: 000251820900025
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2005Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis. SCIENCE. 310:66-67.Full Text via DOI: 10.1126/science.1117105 Web of Science: 000232477000035
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2005PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. SCIENCE. 309:1732-1735.Full Text via DOI: 10.1126/science.1114297 Web of Science: 000231836700047
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2005BH3 domains of BH3-only proteins differentially regulate bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Molecular Cell. 17:525-535.Full Text via DOI: 10.1016/j.molcel.2005.02.003 Web of Science: 000227143400009
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2004Cytoplasmic p53 - Bax and forward. Cell Cycle. 3:429-431.Web of Science: 000222361700014
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2004Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. SCIENCE. 303:1010-1014.Full Text via DOI: 10.1126/science.1092734 Web of Science: 000188918000045
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2003Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription. Cancer Cell. 4:371-381.Full Text via DOI: 10.1016/S1535-6108(03)00272-1 Web of Science: 000186862000008
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2003p53's believe it or not: Lessons on transcription-independent death. Journal of Clinical Immunology. 23:355-361.Full Text via DOI: 10.1023/A:1025365432325 Web of Science: 000184844500003
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2002Identification and characterization of a novel rat ov-serpin family member, trespin. Journal of Biological Chemistry. 277:26412-26421.Full Text via DOI: 10.1074/jbc.M201244200 Web of Science: 000176908700078
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2002The androgen receptor represses transforming growth factor-β signaling through interaction with Smad3. JOURNAL OF BIOLOGICAL CHEMISTRY. 277:1240-1248.Full Text via DOI: 10.1074/jbc.M108855200 Web of Science: 000173166800049
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2001Bcl-xL, blocks transforming growth factor-β1-induced apoptosis by inhibiting cytochrome c release and not by directly antagonizing Apaf-1-dependent caspase activation in prostate epithelial cells. Journal of Biological Chemistry. 276:26614-26621.Full Text via DOI: 10.1074/jbc.M100913200 Web of Science: 000169823300126
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Book Chapter
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2021Mitochondrial Dynamics and Stress Signaling in CancerFull Text via DOI: 10.1093/oxfordhb/9780190932183.013.19
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Conference
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2025Single-cell analysis of BAX responses reveals venetoclax sensitivity and enables development of BAX-targeting combinations in AML. BLOOD. 5069-5069.Full Text via DOI: 10.1182/blood-2025-5069 Web of Science: 001664184500019
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2024Targeting Quiescent Leukemic Stem Cells and Overcoming Therapy Resistance in NUP98-NSD1 Fusion-Positive AML. BLOOD. 1340-1341.Full Text via DOI: 10.1182/blood-2024-208889 Web of Science: 001412547300037
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2024The BRAFV600E induced mitochondrial unfolded protein response informs the melanoma immune landscape and patient survival. JOURNAL OF INVESTIGATIVE DERMATOLOGY. S105-S105.Web of Science: 001276879001370
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2024THE BRAFV600E INDUCED MITOCHONDRIAL UNFOLDED PROTEIN RESPONSE INFORMS THE MELANOMA IMMUNE LANDSCAPE AND PATIENT SURVIVAL. JOURNAL OF GENERAL INTERNAL MEDICINE. S683-S684.Web of Science: 001433572701641
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2023Dual-Label Kinetic Assay to Monitor β-Cell Death and Proliferation. Diabetes.Full Text via DOI: 10.2337/db23-1723-P Web of Science: 001052854604029
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2023Strength of CD28 costimulation modulates differentiation of TCF1+PD1+CD8 T cells through metabolic regulation. Cancer Science. 741-741.Web of Science: 001057570902226
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2022CD28 signaling controls maintenance and differentiation of PD1+CD8 T cells during chronic antigen stimulation. CANCER RESEARCH.Web of Science: 000892509507399
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2020PCDH7 REGULATES OXIDATIVE PHOSPHORYLATION IN HEPATIC STELLATE CELLS. HEPATOLOGY. 211A-211A.Web of Science: 000574027000325
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2020A Functional Mitochondrial Unfolded Protein Response Regulates Mitochondrial Biology and Promotes Tumorigenesis in Melanoma. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. S274-S274.Web of Science: 000792068400785
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2019Dietary intake regulates the circulating inflammatory monocyte pool. European Journal of Immunology. 178-178.Web of Science: 000487085200292
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2019MAPK RENDERS DENDRITIC CELLS IN LANGERHANS CELL HISTIOCYTOSIS LESIONS TRAPPED AND RESISTANT TO CELL DEATH. PEDIATRIC BLOOD & CANCER. S3-S3.Web of Science: 000449991100006
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2018MDM2 integrates cellular respiration and apoptotic signaling through NDUFS1 and the mitochondrial network.. MOLECULAR BIOLOGY OF THE CELL.Web of Science: 000505772703057
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2018Origins of fractional control in regulated cell death. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2018-375 Web of Science: 000468818901439
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2016The Mitochondrial Candidate: Effects of BAM15 on BRAFV600E Melanoma. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. S264-S265.Web of Science: 000374763800737
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2016Understanding how oncogenic MAPK signaling inhibitors regulate mitochondrial function and survival in human melanoma. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. S103-S103.Web of Science: 000374763800287
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2015Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates With BRAFV600E Nevi Progression to Melanoma. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY. S148-S148.Web of Science: 000352578900411
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2014DRP1 serine 616 phosphorylation: A potential biomarker for BRAFV600E melanoma development and treatment. JOURNAL OF INVESTIGATIVE DERMATOLOGY. S4-S4.Web of Science: 000339126100056
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2009Cytosolic p53-Bc1-2 family interactions: Biological insights from structural studies. CANCER RESEARCH.Web of Science: 000209702600306
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2009Cytosolic p53-Bcl-2 family interactions: Biological insights from structural studies. CANCER RESEARCH.Web of Science: 000209701800041
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1999The transport of bifunctional proteins across respiratory epithelia in human tracheal xenografts by exploiting the polymeric immunoglobulin receptor. PEDIATRIC RESEARCH. 351A-351A.Full Text via DOI: 10.1203/00006450-199904020-02085 Web of Science: 000079476702069
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Editorial Material
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2015BCL-2 proteins: Melanoma lives on the edge. Oncoscience. 729-730.Full Text via DOI: 10.18632/oncoscience.193
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Letter
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2015Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAFV600E Melanoma. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2544-2547.Full Text via DOI: 10.1038/jid.2015.196 Web of Science: 000360995600031
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Other Scholarly Work
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2026RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions (vol 215, pg 319, 2018). Journal of Experimental Medicine (JEM).Full Text via DOI: 10.1084/jem.2016188107092026a Web of Science: 001830530100001
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2026Functional assessment and quantitative kinetic analysis of BAX activation using large unilamellar vesicles. Methods in Cell Biology. 55-80.Full Text via DOI: 10.1016/bs.mcb.2026.02.017
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2025A gated hydrophobic funnel within BAX binds long-chain alkenals to potentiate pro-apoptotic function. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2025-1383 Web of Science: 001499827502301
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2024The death gaze of MEDUSA. Nature Chemical Biology. 1391-1392.Full Text via DOI: 10.1038/s41589-024-01594-5 Web of Science: 001191038400001
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2024New trends in cell death: overview of the International Society of Cell Death (ICDS) annual meeting in Johannesburg South Africa (May 19-22, 2023). Cell Communication and Signaling.Full Text via DOI: 10.1186/s12964-024-01534-9 Web of Science: 001185614400002
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2023A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma (vol 13, 6041, 2022). NATURE COMMUNICATIONS.Full Text via DOI: 10.1038/s41467-022-33377-8 Web of Science: 001164830900058
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2023An optimized high-yield protocol for expression and purification of monomeric full-length BAX protein.. bioRxiv.Full Text via DOI: 10.1101/2023.10.16.562589
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2023A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma (vol 13, 6041, 2022). NATURE COMMUNICATIONS.Full Text via DOI: 10.1038/s41467-023-37640-4 Web of Science: 001191031100001
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2023A local tumor microenvironment acquired super-enhancer induces an oncogenic driver in colorectal carcinoma. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2023-3481 Web of Science: 001008499100416
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2023The multifaceted roles of mitochondria. Molecular Cell. 819-823.Full Text via DOI: 10.1016/j.molcel.2023.02.030 Web of Science: 000959445300001
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2022CD28 signaling strength regulates the cell fate of TCF-1+ PD-1+ CD8 T cells. JOURNAL OF IMMUNOLOGY.Full Text via DOI: 10.4049/jimmunol.208.Supp.55.09 Web of Science: 000892531600223
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2019Think We Understand the Role of DRP1 in Mitochondrial Biology? Zinc Again!. Molecular Cell. 197-198.Full Text via DOI: 10.1016/j.molcel.2018.12.024 Web of Science: 000456741300002
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2017Lymphatic endothelium increases antioxidant capacity of triple-negative breast cancer cells and protects from cell death. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2017-LB-333 Web of Science: 000442496700446
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2017Lymphatic endothelium protects breast cancer cells from death by inducing metabolic adaptations. CANCER RESEARCH.Full Text via DOI: 10.1158/1538-7445.AM2017-443 Web of Science: 000442496701436
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2017Robust high-throughput kinetic analysis of apoptosis with real-time high-content live-cell imaging (vol 7, e2493, 2016). Cell Death and Disease.Full Text via DOI: 10.1038/cddis.2017.156 Web of Science: 000402195700024
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2017The peroxisomes strike BAK: Regulation of peroxisome integrity by the Bcl-2 family. Journal of Cell Biology. 547-549.Full Text via DOI: 10.1083/jcb.201701187 Web of Science: 000395826200008
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2016Special Issue on Cell Death: Murder, mystery (and a little bit of mayhem) in Manhattan. The FEBS Journal. 2565-2567.Full Text via DOI: 10.1111/febs.13782 Web of Science: 000383602700001
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2016Cell Biology: ERADicating Survival with BOK. CURRENT BIOLOGY. R473-R476.Full Text via DOI: 10.1016/j.cub.2016.04.003 Web of Science: 000377390700013
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2008Apoptosis - Stabbed in the BAX. NATURE. 1047-1049.Full Text via DOI: 10.1038/4551047a Web of Science: 000260252600025
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2006p53 and metabolism: Inside the TIGAR. Cell. 30-32.Full Text via DOI: 10.1016/j.cell.2006.06.032 Web of Science: 000239224800013
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Preprint
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Review
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2025Mitochondrial metabolism: A moving target in hepatocellular carcinoma therapy. Journal of Cellular Physiology.Full Text via DOI: 10.1002/jcp.31441 Web of Science: 001319592600001
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2024Dynamic death decisions: How mitochondrial dynamics shape cellular commitment to apoptosis and ferroptosis. DEVELOPMENTAL CELL. 2549-2565.Full Text via DOI: 10.1016/j.devcel.2024.09.004 Web of Science: 001387993300001
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2023Apoptotic cell death in disease-Current understanding of the NCCD 2023. Cell Death and Differentiation. 1097-1154.Full Text via DOI: 10.1038/s41418-023-01153-w Web of Science: 000992438100001
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2021Mechanistic connections between mitochondrial biology and regulated cell death. DEVELOPMENTAL CELL. 1221-1233.Full Text via DOI: 10.1016/j.devcel.2021.03.033 Web of Science: 000646730200005
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2019MDM2 and mitochondrial function: One complex intersection. Biochemical Pharmacology. 14-20.Full Text via DOI: 10.1016/j.bcp.2018.10.032 Web of Science: 000462952700003
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2018Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death and Differentiation. 486-541.Full Text via DOI: 10.1038/s41418-017-0012-4 Web of Science: 000426395800006
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2017Mitochondrial dynamics as regulators of cancer biology. CELLULAR AND MOLECULAR LIFE SCIENCES. 1999-2017.Full Text via DOI: 10.1007/s00018-016-2451-3 Web of Science: 000400856800005
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2016Physiological and Pharmacological Control of BAK, BAX, and Beyond. Trends in Cell Biology. 906-917.Full Text via DOI: 10.1016/j.tcb.2016.07.002 Web of Science: 000389096800004
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2016The deadly landscape of pro-apoptotic BCL-2 proteins in the outer mitochondrial membrane. The FEBS Journal. 2676-2689.Full Text via DOI: 10.1111/febs.13624 Web of Science: 000383602700010
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2015Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 58-73.Full Text via DOI: 10.1038/cdd.2014.137 Web of Science: 000347841600008
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2014Death upon a Kiss: Mitochondrial Outer Membrane Composition and Organelle Communication Govern Sensitivity to BAK/BAX-Dependent Apoptosis. CHEMISTRY & BIOLOGY. 114-123.Full Text via DOI: 10.1016/j.chembiol.2013.10.009 Web of Science: 000330082200008
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2014Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?. Cancer & Metabolism.Full Text via DOI: 10.1186/2049-3002-2-16 Web of Science: 000217121500010
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2011Born to be alive: a role for the BCL-2 family in melanoma tumor cell survival, apoptosis, and treatment. Frontiers in Oncology.Full Text via DOI: 10.3389/fonc.2011.00034 Web of Science: 000218145200001
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2011The role of BH3-only proteins in tumor cell development, signaling, and treatment. Genes and Cancer. 523-537.Full Text via DOI: 10.1177/1947601911417177
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2010The BCL-2 Family Reunion. Molecular Cell. 299-310.Full Text via DOI: 10.1016/j.molcel.2010.01.025 Web of Science: 000274774600003
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2008How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?. Trends in Cell Biology. 157-164.Full Text via DOI: 10.1016/j.tcb.2008.01.007 Web of Science: 000255452300002
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2006Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death and Differentiation. 1396-1402.Full Text via DOI: 10.1038/sj.cdd.4401963 Web of Science: 000239084900025
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2006Dissecting p53-dependent apoptosis. Cell Death and Differentiation. 994-1002.Full Text via DOI: 10.1038/sj.cdd.4401908 Web of Science: 000237703600018
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2005Do inducers of apoptosis trigger caspase-independent cell death?. Nature Reviews Molecular Cell Biology. 268-275.Full Text via DOI: 10.1038/nrm1573 Web of Science: 000227303200019
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Contact
full name
- Jerry Chipuk
Identifiers
ORCID iD
- https://orcid.org/0000-0002-1337-842X (confirmed)
