FIU Discovery

Immunomodulatory LncRNA on antisense strand of ICAM-1 augments SARS-CoV-2 infection-associated airway mucoinflammatory phenotype

Novel Alzheimer risk factor IQ motif containing protein K is abundantly expressed in the brain and is markedly increased in patients with Alzheimer's disease

Abstract 2431: A novel role of MUC5AC/CD44v6/c-Met axis in breast cancer brain metastasis.  CANCER RESEARCH.  82:2431-2431.

Increased Expression of LASI lncRNA Regulates the Cigarette Smoke and COPD Associated Airway Inflammation and Mucous Cell Hyperplasia.  FRONTIERS IN IMMUNOLOGY.  13.

Omicron SARS-CoV-2 variant: Unique features and their impact on pre-existing antibodies

The role of synthetic coolants, WS-3 and WS-23, in modulating E-cigarette-induced reactive oxygen species (ROS) in lung epithelial cells

Distinct Exosomal miRNA Profiles from BALF and Lung Tissue of COPD and IPF Patients

Evolutionary analysis of the Delta and Delta Plus variants of the SARS-CoV-2 viruses

TFEB protein expression is reduced in aged brains and its overexpression mitigates senescence-associated biomarkers and memory deficits in mice.  NEUROBIOLOGY OF AGING.  106:26-36.

SARS-CoV-2 Infection in the Central and Peripheral Nervous System-Associated Morbidities and Their Potential Mechanism.  MOLECULAR NEUROBIOLOGY.  58:2465-2480.

A long noncoding RNA antisense to ICAM-1 is involved in allergic asthma associated hyperreactive response of airway epithelial cells.  MUCOSAL IMMUNOLOGY.  14:630-639.

SARS-CoV-2, Inflammatory Apoptosis, and Cytokine Storm Syndrome

HIV-1 Productively Infects and Integrates in Bronchial Epithelial Cells.  FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY.  10.

Differential plasma exosomal long non-coding RNAs expression profiles and their emerging role in E-cigarette users, cigarette, waterpipe, and dual smokers.  PLOS ONE.  15.

Gestational Exposure to Cigarette Smoke Suppresses the Gasotransmitter H₂S Biogenesis and the Effects Are Transmitted Transgenerationally.  FRONTIERS IN IMMUNOLOGY.  11.

ApoL6 Induces Dichotomous Cell Death Phenotype Involving Both Apoptosis and Necroptosis in Cancer Cells

Apoptosis Cellular Models in Cancer Therapeutics

Development of Multifunctional Biopolymeric Auto-Fluorescent Micro- and Nanogels as a Platform for Biomedical Applications.  FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY.  8.

Pulmonary Toxicity and the Pathophysiology of Electronic Cigarette, or Vaping Product, Use Associated Lung Injury.  FRONTIERS IN PHARMACOLOGY.  10.

Acetylcholinesterase Inhibitor Pyridostigmine Bromide Attenuates Gut Pathology and Bacterial Dysbiosis in a Murine Model of Ulcerative Colitis.  DIGESTIVE DISEASES AND SCIENCES.  65:141-149.

Development and challenges of nanotherapeutic formulations for targeting mitochondrial cell death pathways in lung and brain degenerative diseases.  CRC CRITICAL REVIEWS IN BIOMEDICAL ENGINEERING.  48:137-152.

Nontoxic amphiphilic carbon dots as promising drug nanocarriers across the blood-brain barrier and inhibitors of β-amyloid.  NANOSCALE.  11:22387-22397.

MRI-Guided, Noninvasive Delivery of Magneto-Electric Drug Nanocarriers to the Brain in a Nonhuman Primate.  ACS APPLIED BIO MATERIALS.  2:4826-4836.

TGF-β1 increases viral burden and promotes HIV-1 latency in primary differentiated human bronchial epithelial cells.  SCIENTIFIC REPORTS.  9.

Nanoparticle based treatment for cardiovascular diseases

Cigarette smoke and HIV synergistically affect lung pathology in cynomolgus macaques

A Small Molecule BH3-mimetic Suppresses Cigarette Smoke-Induced Mucous Expression in Airway Epithelial Cells.  SCIENTIFIC REPORTS.  8.

Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation.  MUCOSAL IMMUNOLOGY.  11:741-751.

IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells.  SCIENTIFIC REPORTS.  8.

Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria.  NATURE COMMUNICATIONS.  8.

Gestational Exposure to Sidestream (Secondhand) Cigarette Smoke Promotes Transgenerational Epigenetic Transmission of Exacerbated Allergic Asthma and Bronchopulmonary Dysplasia.  JOURNAL OF IMMUNOLOGY.  198:3815-3822.

Connective Tissue Growth Factor Promotes Pulmonary Epithelial Cell Senescence and Is Associated with COPD Severity.  COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE.  14:228-237.

Extent of allergic inflammation depends on intermittent versus continuous sensitization to house dust mite

T cells suppress memory-dependent rapid mucous cell metaplasia in mouse airways.  RESPIRATORY RESEARCH.  17.

APO-9′-Fucoxanthinone Extracted from Undariopsis peteseniana Protects Oxidative Stress-Mediated Apoptosis in Cigarette Smoke-Exposed Human Airway Epithelial Cells.  MARINE DRUGS.  14.

Bik Mediates Caspase-Dependent Cleavage of Viral Proteins to Promote Influenza A Virus Infection.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  54:664-673.

HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.  PLOS ONE.  10.

Wood Smoke Enhances Cigarette Smoke-Induced Inflammation by Inducing the Aryl Hydrocarbon Receptor Repressor in Airway Epithelial Cells.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  52:377-386.

A genetic variant of p53 restricts the mucous secretory phenotype by regulating SPDEF and Bcl-2 expression.  NATURE COMMUNICATIONS.  5.

Gestational Exposure of Mice to Secondhand Cigarette Smoke Causes Bronchopulmonary Dysplasia Blocked by the Nicotinic Receptor Antagonist Mecamylamine.  ENVIRONMENTAL HEALTH PERSPECTIVES.  121:957-964.

Deacetylation of p53 induces autophagy by suppressing Bmf expression

Acute Inflammation Induces Insulin-like Growth Factor-1 to Mediate Bcl-2 and Muc5ac Expression in Airway Epithelial Cells.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY.  47:784-791.

Intracellular Insulin-like Growth Factor-1 Induces Bcl-2 Expression in Airway Epithelial Cells.  JOURNAL OF IMMUNOLOGY.  188:4581-4589.

Cowpox virus inhibits human dendritic cell immune function by nonlethal, nonproductive infection.  VIROLOGY.  412:411-425.

Human tissue factor pathway inhibitor-2 is internalized by cells and translocated to the nucleus by the importin system.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.  482:58-65.

Discriminating Virulence Mechanisms among Bacillus anthracis Strains by Using a Murine Subcutaneous Infection Model.  INFECTION AND IMMUNITY.  77:429-435.

Identification of a human TFPI-2 splice variant that is upregulated in human tumor tissues

Identification of a novel human tissue factor splice variant that is upregulated in tumor cells.  INTERNATIONAL JOURNAL OF CANCER.  118:1713-1720.

Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 in complex with trypsin - Implications for KD1 specificity of inhibition

A reference preparation of buffalo pituitary follicle stimulating hormone using lectin affinity chromatography

Crystal Structure of Kunitz Domain 1 (KD1) of Tissue Factor Pathway Inhibitor-2 with Trypsin and Molecular Model of KD1 with Plasmin and Factor VIIa/Tissue Factor: Implications for KD1 Specificity of Inhibition..  BLOOD.  104:121.

Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2.  JOURNAL OF BIOLOGICAL CHEMISTRY.  279:17500-17507.

The effect of human tissue factor pathway inhibitor-2 on the growth and metastasis of fibrosarcoma tumors in athymic mice.  BLOOD.  103:1069-1077.

Molecular cloning, expression, and characterization of bovine tissue factor pathway inhibitor-2.  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS.  417:96-104.

Human tissue factor pathway inhibitor-2 does not bind or inhibit activated matrix metalloproteinase-1.  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS.  1621:242-245.

Induction of hepatic antioxidants in freshwater catfish (Channa punctatus Bloch) is a biomarker of paper mill effluent exposure.  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS.  1523:37-48.

Hydrogels in Tissue Engineering.  105-122.

Cell-Line-Based Studies of Nanotechnology Drug-Delivery Systems: A Brief Review.  375-393.

Chapter 12 Cell-Line-Based Studies of Nanotechnology Drug-Delivery Systems A Brief Review.  375-393.

Cigarette Smoke Exposure Increases the Airway Epithelial Cell Susceptibility to HIV-1 Infection Mediated by ICAM-1 and Long Noncoding RNAs.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Exosomal miR122, a Potential Prognostic Marker and Therapeutic Target in COPD.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Immunomodulatory LASI lncRNA Regulates Cigarette Smoke Exacerbated SARS-CoV-2 Infectivity in COPD Airway Epithelial Cells.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

MiR-150-5p Modulates Pulmonary Inflammation and Secretory Mucin Expression Associated with Cigarette Smoke-Induced Chronic Obstructive Pulmonary Disease.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Genomic Integration and Productive Infection of HIV-1 in Human Bronchial Epithelial Cells and Persistence of HIV-Proviral RNA in Axial Airway Epithelium of HAART-Treated Patients.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Severe COVID19 Patients and a 3D Airway Tissue Model of SARS-CoV-2 Infection Express High Levels of Airway Mucins and Associated Immunomodulatory Long Noncoding RNAs.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

The Novel Long Noncoding RNA Transcript LASI Is Associated with Smoke-Induced Inflammation and Airway Pathology of COPD Patients.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

A Long Noncoding RNA Antisense to ICAM-1 Is Involved in Allergic Asthma Associated Hyperreactive Mucous Response of Airway Epithelial Cells.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Effect of TGF-Beta Induced Aberrant Micrornaomics on Cliogenesis in Primary Human Bronchial Epithelial Cells.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

The Role of MTFP1 in Regulating Airway Epithelial Mitochondria! Dynamics and Inflammatory Responses Following Cigarette Smoke Exposure and in COPD.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Bio-distribution and bio-safety assessment of magneto-electric nanoparticles in non-human primate.  JOURNAL OF NEUROVIROLOGY. S40-S41.

Intranasal Nanodelivery of Oxytocin to Treat Drug Addiction in HIV Patients using CRISPR Gene Editing.  JOURNAL OF NEUROVIROLOGY. S39-S39.

Intranasal Nanodelivery of Oxytocin to Treat Drug Addiction in HIV Patients using CRISPR Gene Editing.  JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S39-S39.

Cigarette Smoke Exposure Alters the Airway Epithelial Cell Fate by Modulating Mitochondrial Morphology and Bcl-2 Levels.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Mucoobstructive Lung Disease in the Era of Antiretroviral Therapy - A One-Two Blow of Tobacco Smoke Exposure and HIV Infection.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

The Bcl-2 Family Protein, Noxa, Inhibits NF-kappa B-Mediated Inflammation in Airway Epithelia by Delaying I kappa B alpha Degradation.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Transcriptomic Analysis of Early Airway Epithelial Inflammatory Responses.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Development and Delivery of Intranasal Cas9/gRNA Aerosol Nanoformulation to Eradicate Latent HIV-1 in CNS.  JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S58-S59.

MRI-assisted magnetically guided CNS delivery of magneto-electro nanoparticles in non-human primate.  JOURNAL OF NEUROIMMUNE PHARMACOLOGY. S48-S48.

Bik Selectively Induces Cell Death Only In Hyperplastic But Not Resting Airway Cells.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

A New Role For The Bcl-2 Family Of Proteins In Blocking Nf-Kappab Activation And Regulating House Dust Mite-Induced Inflammation.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

A Peptide Modeled After The Bik Bh3 Helix Dissociates The Bak-Bcl-2 Complex To Stabilize Bak And Reduce Allergen- And Cigarette Smoke-Induced Mucous Cell Metaplasia In Culture And In Vivo.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Connective Tissue Growth Factor That Promotes Pulmonary Epithelial Cell Senescence Is A Severity-Dependent Biomarker For COPD.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Innate Memory Of Airway Epithelial Cells Augments LPS-Induced Mucous Secretory Response.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

A Novel Role Of Bcl-2 Family Proteins In Regulating Nf-kappa b-Mediated Inflammation.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

A Small Molecule Bcl-2 Inhibitor Switches Il-13 To A Cell Death Inducer For Allergen-Induced Metaplastic Mucous Cells.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Noxa In Airway Epithelia Is Cross-Linked To Hsp27 And Inhibits Inflammation And The Development Of Emphysema.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Blocking Bcl-2 Switches Il-13 Into A Cell Death Inducer And Reduces Allergic Airway Inflammation And Mucous Cell Metaplasia.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Wood Smoke Exacerbates Cigarette Smoke-Induced Inflammation By Suppressing The Anti-Inflammatory Arachidonic Acid Pathway.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Bik Interacts With DAP-Kinase And ERK1/2 To Activate Bak And Cause Cell Death In Hyperplastic Epithelial Cells.  a6264-a6264.

IL-13 Induces BCL-2 Levels In Airway Epithelial Cells To Counter BIK Mediated Cell Death And Facilitate MUC5AC Expression.  a5106-a5106.

NOXA Interacts With HSP27 To Inhibit NF-ºB-Mediated Inflammation In Cigarette Smokers.  a1318-a1318.

Targeted Disruption Of Bcl2-Interacting Killer (Bik) Augments Cigarette Smoke-Induced Lung Inflammation And Persistence Of Emphysema In Mice.  a5287-a5287.

Insulin-Like Growth Factor-I Mediates IL-1Beta-Induced BCL-2 Expression In Hyperplastic Mucous Cells In Cystic Fibrosis And Chronic Bronchitis.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Insulin-Like Growth Factor-I Modulates Bcl-2 Expression in Hyperplastic Mucous Cells.  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Localization and Enumeration of Human Lung Dendritic Cells from Asthmatic Patients Undergoing Anti-IgE Therapy: A Multispectral Confocal Microscopy Study..  AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE.

Crystal structure of Kunitz domain 1 (KD1) of tissue factor pathway inhibitor-2 with trypsin and molecular model of KD1 with plasmin and factor VIIa/tissue factor: Implications for KD1 specificity of inhibition..  BLOOD. 38A-38A.

The plasmin inhibitor TFPI-2 blocks mononuclear cell transepithelial migration into airways in a murine model of allergic asthma.  44.

The effect of human tissue factor pathway inhibitor-2 on the growth and metastasis of fibrosarcoma tumors in athymic mice..  BLOOD. 186B-186B.

Metabolomics to Predict Antiviral Drug Efficacy in COVID-19.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 396-398.

Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner.  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1456-+.

Anti-IgE therapy results in decreased myeloid dendritic cells in asthmatic airways.  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1157-1158.

Quantitative real-time reverse transcription polymerase chain reaction analysis of a novel tissue factor splice variant in select human solid tumors.  640-641.

Increased expression of LASI LncRNA regulates the cigarette smoke and COPD associated airway inflammation and mucous cell hyperplasia (vol 13, 803362, 2022).  FRONTIERS IN IMMUNOLOGY.

Distinct Mucoinflammatory Phenotype and the Immunomodulatory Long Noncoding Transcripts Associated with SARS-CoV-2 Airway Infection

Lung Bronchial Epithelial Cells are HIV Targets for Proviral Genomic Integration

Erratum: Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2 (Journal of Biological Chemistry (2004) 279 (17500-17507)).  JOURNAL OF BIOLOGICAL CHEMISTRY. 24906.

Structure-function analysis of the reactive site in the first Kunitz-type domain of human tissue factor pathway inhibitor-2 (vol 279, pg 17500, 2004).  JOURNAL OF BIOLOGICAL CHEMISTRY. 24906-24906.

Distinct Exosomal miRNA Profiles from BALF and Lung Tissue from COPD and IPF Patients

Distinct exosomal miRNA profiles from BALF and lung tissue from COPD and IPF patients

E-Cigarette Synthetic Cooling Agent WS-23 and Nicotine Aerosols Differentially Modulate Airway Epithelial Cell Responses

Synthetic Coolant WS-23 increases E-Cigarette Generated Aerosolized Acellular Reactive Oxygen Species (ROS) Levels

Rethinking the chemokine cascade in brain metastasis: Preventive and therapeutic implications.  914-930.

Human Immunodeficiency Virus and Severe Acute Respiratory Syndrome Coronavirus 2 Coinfection: A Systematic Review of the Literature and Challenges.  AIDS RESEARCH AND HUMAN RETROVIRUSES. 266-282.

Cellular stress responses and dysfunctional Mitochondrial-cellular senescence, and therapeutics in chronic respiratory diseases.  REDOX BIOLOGY.

Role of Non-Coding RNAs in Lung Circadian Clock Related Diseases

Long Noncoding Transcriptome in Chronic Obstructive Pulmonary Disease.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 678-688.

Nanoparticle-mediated approaches for Alzheimer's disease pathogenesis, diagnosis, and therapeutics.  JOURNAL OF CONTROLLED RELEASE. 125-140.

Intimacy and a deadly feud: the interplay of autophagy and apoptosis mediated by amino acids.  2089-2099.

Molecular Processes that Drive Cigarette Smoke-Induced Epithelial Cell Fate of the Lung.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 471-482.

Structure, function and biology of tissue factor pathway inhibitor-2.  1122-1130.