Overview
research interests
- Physics of the eye and visual system: Macular pigment and its possible relationship with age-related macular degeneration; non-invasive measurement of the macular pigment; cumulative light distribution on the human retina.
Scholarly & Creative Works
selected scholarly works & creative activities
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Article
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2018Efficacy of Diacetate Esters of Macular Carotenoids: Effect of Supplementation on Macular Pigment. JOURNAL OF NUTRITION AND METABOLISM. 2018.Full Text via DOI: 10.1155/2018/4632081 Web of Science: 000427231400001
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2016Lens density measurements by two independent psychophysical techniques. EYE AND VISION. 3.Full Text via DOI: 10.1186/s40662-016-0054-6 Web of Science: 000457297000023
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2014Improved charge transport of Nb-doped TiO2 nanorods in methylammonium lead iodide bromide perovskite solar cells. JOURNAL OF MATERIALS CHEMISTRY A. 2:19616-19622.Full Text via DOI: 10.1039/c4ta02635g Web of Science: 000344598700007
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2013Innovative Troxler-free measurement of macular pigment and lens density with correction of the former for the aging lens. JOURNAL OF BIOMEDICAL OPTICS. 18.Full Text via DOI: 10.1117/1.JBO.18.10.107003 Web of Science: 000326563000051
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2012Comparison of dietary supplementation with lutein diacetate and lutein: a pilot study of the effects on serum and macular pigment. ACTA BIOCHIMICA POLONICA. 59:167-169.Web of Science: 000302255700040
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2012Light distributions on the retina: relevance to macular pigment photoprotection. ACTA BIOCHIMICA POLONICA. 59:91-96.Web of Science: 000302255700021
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2010Dose-dependent response of serum lutein and macular pigment optical density to supplementation with lutein esters. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 504:50-55.Full Text via DOI: 10.1016/j.abb.2010.06.019 Web of Science: 000283673300008
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2007Macular pigment, photopigments, and melanin: Distributions in young subjects determined by four-wavelength reflectometry. VISION RESEARCH. 47:3259-3268.Full Text via DOI: 10.1016/j.visres.2007.09.002 Web of Science: 000251743000004
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2007Optical anisotropy of the human cornea determined with a polarizing microscope. APPLIED OPTICS. 46:8351-8357.Full Text via DOI: 10.1364/AO.46.008351 Web of Science: 000254673900020
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2007Macular pigment response to a supplement containing meso-zeaxanthin, lutein and zeaxanthinFull Text via DOI: 10.1186/1743-7075-4-12 Web of Science: 000246586100001
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2006Dose-ranging study of lutein supplementation in persons aged 60 years or older. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 47:5227-5233.Full Text via DOI: 10.1167/iovs.05-1513 Web of Science: 000242404900016
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2004Macular pigment and the edge hypothesis of flicker photometry. VISION RESEARCH. 44:3045-3051.Full Text via DOI: 10.1016/j.visres.2004.07.008 Web of Science: 000224631100007
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2004Dietary lutein & zeaxanthin: reducing the risk for macular degeneration. AGRO FOOD INDUSTRY HI-TECH. 15:22-25.Web of Science: 000227505800007
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2003Lutein and zeaxanthin dietary supplements raise macular pigment density and serum concentrations of these carotenoids in humans. JOURNAL OF NUTRITION. 133:992-998.Full Text via DOI: 10.1093/jn/133.4.992 Web of Science: 000182036700003
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2001Macular pigment in donor eyes with and without AMD: A case-control study. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 42:235-240.Web of Science: 000166159400035
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2000Lutein and zeaxanthin in the eyes, serum and diet of human subjects. EXPERIMENTAL EYE RESEARCH. 71:239-245.Full Text via DOI: 10.1006/exer.2000.0870 Web of Science: 000089435900004
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1999Carotenoids in the human retinaFull Text via DOI: 10.1351/pac199971122237 Web of Science: 000088728300005
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1997A one year study of the macular pigment: The effect of 140 days of a lutein supplement. EXPERIMENTAL EYE RESEARCH. 65:57-62.Full Text via DOI: 10.1006/exer.1997.0309 Web of Science: A1997XL81500008
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1997Distribution of lutein and zeaxanthin stereoisomers in the human retina. EXPERIMENTAL EYE RESEARCH. 64:211-218.Full Text via DOI: 10.1006/exer.1996.0210 Web of Science: A1997WL80400011
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1993STEREOCHEMISTRY OF THE HUMAN MACULAR CAROTENOIDS. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 34:2033-2040.Web of Science: A1993LB75500018
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1992OPTICAL-DENSITY SPECTRA OF THE MACULAR PIGMENT INVIVO AND INVITRO. VISION RESEARCH. 32:105-110.Full Text via DOI: 10.1016/0042-6989(92)90118-3 Web of Science: A1992GY49400014
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1990CORRELATES OF LEAF OPTICAL PROPERTIES IN TROPICAL FOREST SUN AND EXTREME‐SHADE PLANTS. AMERICAN JOURNAL OF BOTANY. 77:370-380.Full Text via DOI: 10.1002/j.1537-2197.1990.tb13566.x
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1990CORRELATES OF LEAF OPTICAL-PROPERTIES IN TROPICAL FOREST SUN AND EXTREME-SHADE PLANTS. AMERICAN JOURNAL OF BOTANY. 77:370-380.Full Text via DOI: 10.2307/2444723 Web of Science: A1990CT14700010
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1990PHOTORECEPTOR-SPECIFIC EFFICIENCIES OF BETA-CAROTENE, ZEAXANTHIN AND LUTEIN FOR PHOTOPIGMENT FORMATION DEDUCED FROM RECEPTOR MUTANT DROSOPHILA-MELANOGASTER. JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY. 166:429-436.Web of Science: A1990CU16300001
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1988ANALYSIS OF THE MACULAR PIGMENT BY HPLC - RETINAL DISTRIBUTION AND AGE STUDY. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 29:843-849.Web of Science: A1988N882700002
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1988LINEAR DICHROISM AND ORIENTATIONAL STUDIES OF CAROTENOID LANGMUIR-BLODGETT FILMS. BIOCHIMICA ET BIOPHYSICA ACTA. 940:255-265.Full Text via DOI: 10.1016/0005-2736(88)90200-3 Web of Science: A1988N608700009
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1985EPIDERMAL-CELLS FUNCTIONING AS LENSES IN LEAVES OF TROPICAL RAIN-FOREST SHADE PLANTS. APPLIED OPTICS. 24:1408-1412.Full Text via DOI: 10.1364/AO.24.001408 Web of Science: A1985AHJ9500009
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1985PRELIMINARY IDENTIFICATION OF THE HUMAN MACULAR PIGMENT. VISION RESEARCH. 25:1531-1535.Full Text via DOI: 10.1016/0042-6989(85)90123-3 Web of Science: A1985AVZ8700001
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1984MACULAR PIGMENT IN HENLE FIBER MEMBRANES - A MODEL FOR HAIDINGER BRUSHES. VISION RESEARCH. 24:103-108.Full Text via DOI: 10.1016/0042-6989(84)90094-4 Web of Science: A1984SE78000003
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1983SIMPLE HEMOGLOBIN SCREENING DEVICE. APPROPRIATE TECHNOLOGY. 9:27-29.Web of Science: A1983QK28800008
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1981DENUDATION RATES, THERMAL EVOLUTION, AND PRESERVATION OF BLUESCHIST TERRAINS. JOURNAL OF GEOLOGY. 89:601-613.Full Text via DOI: 10.1086/628625 Web of Science: A1981MF63300005
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1980The role of the macular pigment in the detection of polarized light. VISION RESEARCH. 20:213-220.Full Text via DOI: 10.1016/0042-6989(80)90105-4
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1976Computer-enhanced resolution as an aid to identifying the macular pigment. VISION RESEARCH. 16:1191-1192.Full Text via DOI: 10.1016/0042-6989(76)90264-9
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1971Comparison of macular pigment densities in human eyes. VISION RESEARCH. 11:1057-1064.Full Text via DOI: 10.1016/0042-6989(71)90112-X
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Book
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2003Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Ed. 23.Full Text via DOI: 10.1146/annurev.nutr.23.011702.073307 Web of Science: 000185093400010
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Book Chapter
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2015The Human Lens: A Living Biometric Indicator of Health Status and Successful Aging. 155-186.Full Text via DOI: 10.1007/978-1-4939-1935-2_10
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2014Light Distribution on the Retina Implications for Age-Related Macular Degeneration. 223-242.Web of Science: 000355206800014
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2014Macular Pigment From Discovery to Function. 1-22.Web of Science: 000355206800003
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2013Multiple Influences of Xanthophylls within the Visual System. 169-192.Full Text via DOI: 10.1201/b15556-13
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2010Quantitative Methods for the Determination of Carotenoids in the Retina. 75-85.Web of Science: 000355146600006
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2010The Functional Role of Xanthophylls in the Primate Retina. 257-282.Web of Science: 000355146600014
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2009Quantitative Methods for the Determination of Carotenoids in the Retina. 75-85.Full Text via DOI: 10.1201/9781420052312-c5
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2009The Functional Role of Xanthophylls in the Primate Retina. 257-282.Full Text via DOI: 10.1201/9781420052312-c13
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2009The Eye. 301-334.Full Text via DOI: 10.1007/978-3-7643-7501-0_15 Web of Science: 000271255500015
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2004
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2002
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Conference
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2020Serum and Macular Pigment Response to a Carotenoid-Containing Nutritional Therapy. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.Web of Science: 000554528304222
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2016Bilateral Macular Protection Pigment and Lens Density Status in Recently Operated Unilateral Pseudophakic Patients. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.Web of Science: 000394210201404
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2015MACULAR CAROTENOIDS AND THEIR MEASUREMENT: SOME OPEN QUESTIONS. EUROPEAN JOURNAL OF OPHTHALMOLOGY. E72-E72.Web of Science: 000363047300062
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2015Validation of the Mapcat for lens density measurements. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.Web of Science: 000362882202383
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2014Three Characteristics of the Central Macula: Light, AMD, and Macular Carotenoids. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.Web of Science: 000433203503176
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2013REPEATABILITY OF A NEW HETEROCHROMATIC FLICKER PHOTOMETER (HFP) FOR MEASURING MACULAR PIGMENT OPTICAL DENSITY. EUROPEAN JOURNAL OF OPHTHALMOLOGY. 608-608.Web of Science: 000324152400043
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2013Evaluation of a novel instrument for simultaneous measurement of macular pigment and lens optical density, and lens equivalent age. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.Web of Science: 000436232708324
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2010Cumulative Light Distribution on the Human Retina Under Natural Viewing Conditions. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.Web of Science: 000442387304365
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2006Macular pigment response to a xanthophyll supplement of lutein, zeaxanthin and meso-zeaxanthin. PROCEEDINGS OF THE NUTRITION SOCIETY. 105A-105A.Web of Science: 000243972600120
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2004Influence of lutein dosage on macular pigment response. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. U531-U531.Web of Science: 000223338001249
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2004Macular pigment (as well as cone and rod photopigment) distribution from a single retinal image: a pilot study. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. U531-U531.Web of Science: 000223338001247
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2004Macular pigment and the edge hypothesis of heterochromatic flicker photometry. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. U532-U532.Web of Science: 000223338001254
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2003Macular pigment and serum response to dietary supplementation with meso-zeaxanthin. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. U79-U79.Web of Science: 000184606800382
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2003Preferential deficiency of meso-zeaxanthin and lutein relative to zeaxanthin in the macular pigment of subjects with age-related macular degeneration. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. U277-U277.Web of Science: 000184607001022
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2002Selenium distribution in the human retina. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. U157-U157.Web of Science: 000184606600703
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2001Dependence of macular pigment density increases on elevated serum levels of lutein and zeaxanthin resulting from supplementation.. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. S233-S233.Web of Science: 000168392101245
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2001Distribution of a minor carotenoid component in the human retina.. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. S224-S224.Web of Science: 000168392101199
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2001Lutein alkyl ethers. FASEB JOURNAL. A297-A297.Web of Science: 000167438101694
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2001Oxidation of lutein and zeaxanthin. FASEB JOURNAL. A297-A297.Web of Science: 000167438101696
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2000Association between macular pigment carotenoids in the peripheral retina and AMD.. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. S600-S600.Web of Science: 000086246703258
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2000Lutein metabolism in human serum and retina. FASEB JOURNAL. A234-A234.Web of Science: 000085918101354
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2000Serum and macular pigment response to 2.4 mg dosage of lutein.. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. S601-S601.Web of Science: 000086246703261
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1999Serum response to low-dosage supplementation with lutein.. FASEB JOURNAL. A552-A552.Web of Science: 000082033303182
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1997A preliminary study of the stereochemistry of human lens zeaxanthin. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 4785-4785.Web of Science: A1997WN21501607
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1995IMPROVED TEMPORAL GAIN AND PHASE MEASUREMENTS (5-45 HZ) LEADING TO A TRIPHASIC IMPULSE-RESPONSE. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. S906-S906.Web of Science: A1995QM91504154
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1995MACULAR PIGMENT STEREOMERS IN INDIVIDUAL EYES - A COMPARISON BETWEEN NORMALS AND THOSE WITH AGE-RELATED MACULAR. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. S892-S892.Web of Science: A1995QM91504085
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1994DISTRIBUTION OF MACULAR PIGMENT STEREOMERS IN INDIVIDUAL EYES, INCLUDING THOSE WITH AGE-RELATED MACULAR DEGENERATION (AMD). INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 1502-1502.Web of Science: A1994MZ58501135
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1993DISTRIBUTION OF THE MACULAR CAROTENOIDS ZEAXANTHIN, MESO-ZEAXANTHIN AND LUTEIN IN THE HUMAN RETINA. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 1199-1199.Web of Science: A1993KT89302435
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1992MACULAR PIGMENT REVEALED AS A MIXTURE OF ZEAXANTHIN, MESO-ZEAXANTHIN, AND LUTEIN BY CHIRAL COLUMN HPLC. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 1010-1010.Web of Science: A1992HK13501601
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1991DETERMINATION OF THE ABSOLUTE-CONFIGURATION OF THE MACULAR PIGMENT CAROTENOIDS. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 1009-1009.Web of Science: A1991FC76201681
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1991GAIN AND PHASE CHARACTERISTICS OF TEMPORAL PROCESSING DETERMINED BY INCREMENT THRESHOLDS. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 840-840.Web of Science: A1991FC76200852
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Letter
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2016Comments on Enrichment of Macular Pigment Enhances Contrast Sensitivity in Subjects Free of Retinal Disease: CREST - Report 1. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 5415-5415.Full Text via DOI: 10.1167/iovs.16-20295 Web of Science: 000392469600043
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1983DICHROISM OF LUTEIN - A POSSIBLE BASIS FOR HAIDINGER BRUSHES. APPLIED OPTICS. 775-776.Full Text via DOI: 10.1364/AO.22.000775 Web of Science: A1983QG75900007
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Other Scholarly Work
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2012Comparison of dietary supplementation with lutein diacetate and lutein. FASEB JOURNAL.Web of Science: 000310711305020
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2007Changes in carotenoid stereoisomers in the primate retina with age. FASEB JOURNAL. A350-A350.Web of Science: 000245708502525
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1997One year study of macular pigment enhancement by a lutein supplement. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 435-435.Web of Science: A1997WN18600433
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1997A 1 year study on the effect of supplementation with lutein on the macular pigment. FASEB JOURNAL. 2588-2588.Web of Science: A1997WL53002586
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1997The macular pigment: a possible role in protection from age-related macular degeneration.. 537-556.Full Text via DOI: 10.1016/s1054-3589(08)60998-9
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1996Dietary lutein supplementation increases macular pigment (MP).. FASEB JOURNAL. 1394-1394.Web of Science: A1996TZ28401392
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1996Effect of dietary supplementation with lutein on macular pigment density. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 532-532.Web of Science: A1996TX39700531
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Review
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2004Heterochromatic flicker photometry. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 137-142.Full Text via DOI: 10.1016/j.abb.2004.04.003 Web of Science: 000224104500002
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2001Lutein, zeaxanthin, and the macular pigment. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 28-40.Full Text via DOI: 10.1006/abbi.2000.2171 Web of Science: 000166375700006
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1999Analysis of zeaxanthin distribution within individual human retinas. METHODS IN ENZYMOLOGY. 457-467.Web of Science: 000079431900040
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1992DISTRIBUTION OF MACULAR PIGMENT COMPONENTS, ZEAXANTHIN AND LUTEIN, IN HUMAN RETINA. METHODS IN ENZYMOLOGY. 360-366.Web of Science: A1992KL57600033
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Works By Students
chaired theses and dissertations
- Mukherjee, Anirbaan, Macular Pigment and Lens Optical Density Measurements-Evaluating a Flicker Machine with Novel Features 2015
- Gibert, Jorge C., Distribution of Light in the Human Retina under Natural Viewing Conditions 2013
- Diaz, Liset, Distribution of light on the human retina 2001
- Chen, Yuping, Improved frequency response measurements in the human visual system 1994
advised honors theses
- Ruiz, Camilo Andres, Selenium Distribution in the Human Retina 2002
Research
principal investigator on
- GHS Bioavailability Study awarded by Guardion Health Sciences 2018 - 2020
- Macular Pigment Research. awarded by Four Leaf Japan 2009 - 2019
- IOSA Bioavailability Study Phase III awarded by Industrial Organica S.A. de CV 2014 - 2016
- The Distribution of Light on the Human Retina awarded by General Medical Sciences 2009 - 2013
- Four Leaf Bioavailability Study Phase 2 awarded by Four Leaf Japan 2010 - 2012
- IOSA Bioavailability Study awarded by Industrial Organica S.A. de CV 2009 - 2011
co-principal investigator on
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Grant
- Industrial Organica/Four Leaf Bioavailability Study. awarded by Four Leaf Japan 2008 - 2009
subproject principal investigator on
- 2007-2008 MBRS Support of Continuous Research Excellence at FIU. awarded by General Medical Sciences 2007 - 2009
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Contact
full name
- Richard Bone
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publication subject areas
Citation index-derived subject areas the researcher has published in