Amphibians are important components of ecosystems worldwide and are already being negatively affected by contemporary rapid changes in climate. Climate strongly affects the distribution, abundance, and ecology of amphibian species. Changes in climate will have impacts on amphibian biodiversity that are not uniform across the globe. We highlight geographic areas expected to have more climate change impacts to amphibians in order to target them for biological mitigation and conservation action. Although adaptation by amphibians to climate change is happening, it will generally be too slow to prevent many negative consequences that will likely happen in the next few decades. We review known and potential impacts of climate change on amphibians and make recommendations for research and conservation actions.