Structural proteomics of arsenic transport and detoxification
Book Chapter
Liu, Z, Mukhopadhyay, R, Shi, J et al. (2003). Structural proteomics of arsenic transport and detoxification
. 241-253. 10.1016/B978-044451441-7/50019-1
Liu, Z, Mukhopadhyay, R, Shi, J et al. (2003). Structural proteomics of arsenic transport and detoxification
. 241-253. 10.1016/B978-044451441-7/50019-1
All living organisms have systems for arsenic detoxification. Common features found in many organisms include: (a) arsenate uptake by phosphate transporters, (b) arsenite uptake by aquaglyceroporins, (c) enzymatic arsenate reduction to arsenite, the substrate of subsequent detoxification mechanisms and (d) arsenite detoxification by active extrusion out of cells or sequestration of As-thiol conjugates. In a number of organisms the genes and protein products for these transporters and enzymes have been identified, and the structures of some have been solved by X-ray crystallography.
