Exploratory study to evaluate changes in serum lipid levels as early diagnostic and/or prognostic indicators for oral submucous fibrosis and cancer among Gutkha consumers in India
Article
Agarwal, A, Tijare, M, Saxena, A et al. (2015). Exploratory study to evaluate changes in serum lipid levels as early diagnostic and/or prognostic indicators for oral submucous fibrosis and cancer among Gutkha consumers in India
. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 16(15), 6439-6444. 10.7314/APJCP.2015.16.15.6439
Agarwal, A, Tijare, M, Saxena, A et al. (2015). Exploratory study to evaluate changes in serum lipid levels as early diagnostic and/or prognostic indicators for oral submucous fibrosis and cancer among Gutkha consumers in India
. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 16(15), 6439-6444. 10.7314/APJCP.2015.16.15.6439
Background: In India smokeless tobacco users account for 25.9% of total tobacco use, Gutkha being the most common form. This study evaluated the association between serum lipid profile and Gutkha use as an early diagnostic and/or prognostic indicator for oral submucous fibrosis (OSMF) and oral cancer (Oral Ca) in non-smokers and non-alcohol consumers. Materials and Methods: A total of 163 participants were recruited from two sites in India. Participants were divided into four groups: individuals without any Gutkha chewing habit and without any oral lesions (control group), individuals with Gutkha chewing habit but without any oral lesions (GWL), patients with a confirmed clinical diagnosis of OSMF, and patients with a confirmed diagnosis of Oral Ca. Mixed linear modelling (MLM) was conducted to detect the change in mean serum lipid levels among four groups. Results: The sample consisted of 69% males and 31% females. Results of MLM show an inverse relationship between serum lipid levels in OSMF, and Oral Ca groups when compared to the control group. Conclusions: The results of our study demonstrated that GWL, OSMF and Oral Ca patients had lower serum lipid l ipid levels. Low serum lipid levels could be an indicator of initial neoplastic changes in oral cancer.
