Spurious Hyperchloremia and Negative Anion Gap in a Child with Refractory Epilepsy.
Article
Chegondi, Madhuradhar, Totapally, Balagangadhar R. (2016). Spurious Hyperchloremia and Negative Anion Gap in a Child with Refractory Epilepsy.
. Case Reports in Critical Care, 2016 7015463. 10.1155/2016/7015463
Chegondi, Madhuradhar, Totapally, Balagangadhar R. (2016). Spurious Hyperchloremia and Negative Anion Gap in a Child with Refractory Epilepsy.
. Case Reports in Critical Care, 2016 7015463. 10.1155/2016/7015463
We report a case with spurious hyperchloremia with negative anion gap in a child who was taking potassium bromide for refractory epilepsy. Blood chemistry showed a high chloride level (171 mEq/L) and a negative anion gap (-52 mEq/L). Plasma chloride concentration is measured by an ion-selective electrode method; however the presence of other anions like bromide and iodides can interfere with chloride level and largely overestimates the chloride concentration. Thus hyperchloremia with a negative anion gap is a clue to the diagnosis of halides like bromide and iodide ingestion.
