Spontaneous Factor XI Inhibitors: Seven Additional Cases and a Review of the Literature Article

Reece, EA, Clyne, LP, Romero, R et al. (1984). Spontaneous Factor XI Inhibitors: Seven Additional Cases and a Review of the Literature . Archives of Internal Medicine, 144(3), 525-529. 10.1001/archinte.1984.00350150119031

cited authors

  • Reece, EA; Clyne, LP; Romero, R; Hobbins, JC

abstract

  • Circulating anticoagulants are endogenous blood components that inhibit the action of clotting factors. In some inhibitor conditions this inactivation in the function of the hemostatic system may lead to life-threatening hemorrhagic diathesis. Inhibitors directed against factor XI are generally associated with little or no impairment of the hemostatic system. We analyzed all reported cases of spontaneous factor XI inhibitor in the international literature, as well as cases identified at the Yale—New Haven (Conn) Hospital between 1970 and 1980, considering clinical spectrum, diagnosis, and therapy. © 1984, American Medical Association. All rights reserved.

authors

publication date

  • January 1, 1984

published in

start page

  • 525

end page

  • 529

volume

  • 144

issue

  • 3