Effect of a CNS-sensitive anticholinesterase methane sulfonyl fluoride on hippocampal acetylcholine release in freely moving rats Article

Imanishi, T, Hossain, MM, Suzuki, T et al. (2012). Effect of a CNS-sensitive anticholinesterase methane sulfonyl fluoride on hippocampal acetylcholine release in freely moving rats . Advances in Pharmacological Sciences, 2012 10.1155/2012/708178

cited authors

  • Imanishi, T; Hossain, MM; Suzuki, T; Xu, P; Sato, I; Kobayashi, H

abstract

  • Anticholinesterases (antiChEs) are used to treat Alzheimer's disease. The comparative effects of two antiChEs, methanesulfonyl fluoride (MSF) and donepezil, on the extracellular levels of ACh in the hippocampus were investigated by in vivo microdialysis in freely moving rats. MSF at 1 and 2mg/kg produced a dose-dependent increase in ACh efflux from 10min to at least 3hrs after injection. At 2mg/kg, the increase was still present at 24hr. Donepezil at 1mg/kg showed a similar but smaller effect, and, paradoxically, 2mg/kg showed no consistent effect. MSF at 1 and 2mg/kg decreased acetylcholinesterase activity in the hippocampus to 54.8 and 20.1% of control, respectively. These results suggest that MSF is a suitable candidate for the treatment of Alzheimer's disease. Copyright © 2012 Tamotsu Imanishi et al.

authors

publication date

  • January 1, 2012

published in

Digital Object Identifier (DOI)

volume

  • 2012