AS3MT: Mechanism Conference

Rosen, BP, Dong, H, Li, JJ. (2016). AS3MT: Mechanism . 400-401. 10.1201/b20466-187

cited authors

  • Rosen, BP; Dong, H; Li, JJ

authors

abstract

  • Arsenic is the most ubiquitous environmental toxin and carcinogen. Human As(III) S-adenosylmethionine (SAM) methyltransferases (hAS3MT) methylates As(III) to trivalent methylated species that are more toxic and potentially more carcinogenic than inorganic arsenic. A synthetic hAS3MT gene was expressed, and the purified enzyme characterized. A new catalytic pathway is proposed in which the products are more toxic trivalent methylarsenicals, but arsenic undergoes oxidation and reduction as enzyme-bound intermediates.

publication date

  • January 1, 2016

Digital Object Identifier (DOI)

International Standard Book Number (ISBN) 13

start page

  • 400

end page

  • 401