Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library Article

Lengyel, Laszlo, Gyollai, Viktor, Nagy, Tamas et al. (2011). Stepwise aromatic nucleophilic substitution in continuous flow. Synthesis of an unsymmetrically substituted 3,5-diamino-benzonitrile library . 15(3), 631-638. 10.1007/s11030-010-9300-3

Industry Collaboration

cited authors

  • Lengyel, Laszlo; Gyollai, Viktor; Nagy, Tamas; Dorman, Gyoergy; Terleczky, Peter; Hada, Viktor; Nogradi, Katalin; Sebok, Ferenc; Uerge, Laszlo; Darvas, Ferenc

authors

publication date

  • August 1, 2011

webpage

keywords

  • AMINATION
  • ANXIOLYTIC ACTIVITY
  • BENZENES
  • Biochemistry & Molecular Biology
  • Chemistry
  • Chemistry, Applied
  • Chemistry, Medicinal
  • Chemistry, Multidisciplinary
  • Continuous flow chemistry
  • DISCOVERY
  • Enhanced parameter space
  • Fluorine-amine exchange
  • HIGH-PRESSURE
  • HIGHLY POTENT
  • Life Sciences & Biomedicine
  • Nucleophilic substitution
  • Pharmacology & Pharmacy
  • Physical Sciences
  • SUBTYPE-5 RECEPTOR ANTAGONISTS
  • Science & Technology

Digital Object Identifier (DOI)

publisher

  • SPRINGER

start page

  • 631

end page

  • 638

volume

  • 15

issue

  • 3