Effects of repeated stress on regeneration of serotonergic and noradrenergic axons in the cerebral cortex of adult rats.
Other Scholarly Work
Liu, Ying, Ishida, Yoshiyuki, Shinoda, Koh et al. (2003). Effects of repeated stress on regeneration of serotonergic and noradrenergic axons in the cerebral cortex of adult rats.
. Neuroscience Letters, 339(3), 227-230. 10.1016/s0304-3940(03)00014-4
Liu, Ying, Ishida, Yoshiyuki, Shinoda, Koh et al. (2003). Effects of repeated stress on regeneration of serotonergic and noradrenergic axons in the cerebral cortex of adult rats.
. Neuroscience Letters, 339(3), 227-230. 10.1016/s0304-3940(03)00014-4
We examined whether regeneration of serotonergic (5-HT) and noradrenergic (NA) axons might be affected by stress. Neurotoxins to 5-HT or NA axons were injected into the frontal cortex to cause partial denervation. Mild restraint stress (40 min/day) was started 16 days later and given for 14 consecutive days (30-day stressed group). Non-stressed animals were divided into two groups, animals sacrificed at 14 days (14-day control group) and those sacrificed at 30 days (30-day control group) after the toxin injection. In immunohistochemical study, the denervation area of 5-HT axons but not that of NA axons was significantly smaller in the 30-day control group than in the 14-day control group. However, there was no significant difference between the 14-day control and 30-day stressed groups. These findings suggested that regeneration of 5-HT axons occurred earlier than that of NA axons, and that stress exerted inhibitory influence on regeneration of 5-HT axons.
