Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons.
Other Scholarly Work
Liu, Ying, Kagechika, Hiroyuki, Ishikawa, Junko et al. (2008). Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons.
. Journal of Neurochemistry, 106(3), 1104-1116. 10.1111/j.1471-4159.2008.05445.x
Liu, Ying, Kagechika, Hiroyuki, Ishikawa, Junko et al. (2008). Effects of retinoic acids on the dendritic morphology of cultured hippocampal neurons.
. Journal of Neurochemistry, 106(3), 1104-1116. 10.1111/j.1471-4159.2008.05445.x
Vitamin A-derived retinoic acids (RAs) are known to exert a variety of biological actions, including modulatory effects on cell differentiation and apoptosis. A recent study has demonstrated that 13-cis-RA and all-trans-RA suppressed neurogenesis in the dentate gyrus of the hippocampus in adult mice. The present experiments were performed to see whether 13-cis-RA and all-trans-RA could alter the dendritic morphology of cultured hippocampal neurons via RA receptors: retinoic acid receptor (RAR) and retinoid X receptor (RXR). High doses of 13-cis-RA and all-trans-RA exerted a negative effect on the cultured hippocampal neurons, while a low dose of 13-cis-RA but not all-trans-RA caused a positive effect. The negative changes induced by 13-cis-RA and all-trans-RA were antagonized by RXR antagonists and RAR antagonists, respectively. The positive changes induced by a low dose of 13-cis-RA were blocked by both RXR antagonists and RAR antagonists. These results suggest that RAs at high concentrations cause a negative effect on the dendritic morphology of cultured hippocampal neurons through RA receptors, while RAs at low concentrations exert a positive influence on cultured hippocampal neurons.
