Effect of aerosolized milrinone during drug-induced pulmonary hypertension in lambs Article

Gelvez, J, Fakioglu, H, Olarte, JL et al. (2004). Effect of aerosolized milrinone during drug-induced pulmonary hypertension in lambs . Pharmacological Research, 50(1), 87-91. 10.1016/j.phrs.2003.12.005

cited authors

  • Gelvez, J; Fakioglu, H; Olarte, JL; Soliz, A; Totapally, BR; Torbati, D

authors

abstract

  • We tested whether aerosolized milrinone in lambs selectively reduces drug-induced acute pulmonary hypertension without reducing the mean systemic blood pressure (MSBP). Seven, 2-3-week-old lambs were anesthetized (50mg/kg ketamine), paralyzed (0.1mg/kg vecuronium bromide) and mechanically ventilated. A femoral artery, pulmonary artery, and jugular vein were catheterized for continuous monitoring of MSBP, mean pulmonary artery pressure, periodic gas-exchange analyses, and determination of cardiac output by thermodilution technique. An Airlife Misty nebulizer was used in a dry state to establish a stable baseline of an inspired fraction of oxygen (FiO2) at 0.21. Acute pulmonary hypertension with hypoxemia was then induced by increasing the mean pulmonary artery pressure up to 30-35% of the MSBP using 2-6μg/kg/min of Thromboxane A2 mimetic (U-46619), intravenously. The lambs were then subjected to 15min of saline nebulization without milrinone followed by 30min saline nebulization with a relatively high concentration of milrinone (10mg/ml, total dose of 40mg). Aerosolized milrinone had no effect on systemic or pulmonary artery pressure during combined acute pulmonary hypertension and hypoxemia. We speculate that our nebulization procedures failed to deliver sufficient amount of milrinone for producing a detectable hemodynamic effect. © 2003 Elsevier Ltd. All rights reserved.

publication date

  • July 1, 2004

published in

Digital Object Identifier (DOI)

start page

  • 87

end page

  • 91

volume

  • 50

issue

  • 1