Severe sepsis and septic shock in children: Pathophysiology and management - Part I Article

Totapally, BR. (2005). Severe sepsis and septic shock in children: Pathophysiology and management - Part I . International pediatrics : the journal of the Miami Children's Hospital, 20(3), 162-172.

cited authors

  • Totapally, BR

authors

abstract

  • Sepsis is the most common cause of death in infants and children throughout the world. Recent epidemiologic studies indicate increasing incidence of sepsis. Sepsis and septic shock are the end-result of interactions between invading microorganism or their products. The microbes and their products stimulate a wide range of effects including release of cytokines, activation of complement and coagulation pathways, and aggregation of platelets. The pathogenesis of sepsis is complex involving generation and participation of more than 150 mediators that are currently known. This review article describes the epidemiology, pathogenesis, and pathophysiology of sepsis and septic shock. Copyright © 2005 Miami Children's Hospital.

publication date

  • September 1, 2005

published in

start page

  • 162

end page

  • 172

volume

  • 20

issue

  • 3