Autophagy regulation as a promising approach for improving cancer immunotherapy.
Other Scholarly Work
Ishimwe, Nestor, Zhang, Wenbin, Qian, Jieying et al. (2020). Autophagy regulation as a promising approach for improving cancer immunotherapy.
. Cancer Letters, 475 34-42. 10.1016/j.canlet.2020.01.034
Ishimwe, Nestor, Zhang, Wenbin, Qian, Jieying et al. (2020). Autophagy regulation as a promising approach for improving cancer immunotherapy.
. Cancer Letters, 475 34-42. 10.1016/j.canlet.2020.01.034
Autophagy plays a critical role in intracellular metabolism and maintaining cellular homeostasis. Certain tumor cells present a higher basal autophagy rate and autophagy inhibition can lead to impaired metabolic dysfunction in autophagy-dependent tumor cells. Autophagy status in immune cells dictates their fate and response to antigen; however, autophagy in immune cells may be beneficial or detrimental depending on the developmental stage of the cell and more specifically its degree of differentiation. Autophagy-deficient hosts present variations in many metabolites, proteins and enzymes that may have tumor-promoting or -inhibiting effects. The centrality of autophagy in the metabolism of some cancers and immune cells poses as a critical target whose mechanisms must be further unraveled to optimize patient response and prevent tumor recurrence.
