In keeping with several overview approaches suggested by Aldert Vrij and colleagues, we emphasize the role of cognition in detecting deception and suggest methods to magnify the differences between liars and truth-tellers. A persistent theme is that both the interviewee and the interviewer have limited cognitive resources. We describe how interviewers can take advantage of interviewees' limited cognition and the resulting strategies interviewees devise. A novel aspect of the chapter addresses the cognitive resources of the interviewer, and how interviewers can take their own cognitive limitations into account to perform more efficiently. In the interest of science as a “community approach,” we suggest novel experimental strategies and invite the reader to improve upon and/or test the suggestions.