Pharmacokinetics, Target Engagement of an Immunoproteasome Subunit Low-Molecular-Mass Polypeptide-2 (LMP2) Inhibitor AR-01, and Its Anti-Alzheimer's Effects in Rodents Article

Thapa Magar, Til Bahadur, Kim, Minsu, Kim, Yoonha et al. (2026). Pharmacokinetics, Target Engagement of an Immunoproteasome Subunit Low-Molecular-Mass Polypeptide-2 (LMP2) Inhibitor AR-01, and Its Anti-Alzheimer's Effects in Rodents . ACS Pharmacology and Translational Science, 9(7), 1869-1880. 10.1021/acsptsci.6c00116

cited authors

  • Thapa Magar, Til Bahadur; Kim, Minsu; Kim, Yoonha; Choi, Eun Young; Choi, Yoon Kyung; Kim, Dong-Eun; Kim, Kyung Bo; Park, Ji Eun

authors

publication date

  • July 10, 2026

published in

keywords

  • CARFILZOMIB
  • Chemistry, Medicinal
  • DISEASE
  • INDUCTION
  • IRREVERSIBLE INHIBITOR
  • Life Sciences & Biomedicine
  • METABOLISM
  • NEUROINFLAMMATION
  • Pharmacology & Pharmacy
  • Science & Technology
  • UBIQUITIN-PROTEASOME PATHWAY
  • alzheimer'sdisease
  • immunoproteasome inhibitors
  • macrocyclicpeptide epoxyketone
  • pharmacokinetics
  • target engagement

Digital Object Identifier (DOI)

publisher

  • AMER CHEMICAL SOC

start page

  • 1869

end page

  • 1880

volume

  • 9

issue

  • 7