Role of Pro-, Pre-, and Post-Biotic Targeting Gut Microbes for ROS Inhibition
Book Chapter
Kaur, N, Kumar, S, Pandey, NK et al. (2026). Role of Pro-, Pre-, and Post-Biotic Targeting Gut Microbes for ROS Inhibition
. 389-415. 10.1007/978-3-032-11752-6_20
Kaur, N, Kumar, S, Pandey, NK et al. (2026). Role of Pro-, Pre-, and Post-Biotic Targeting Gut Microbes for ROS Inhibition
. 389-415. 10.1007/978-3-032-11752-6_20
Reactive oxygen species (ROS) produced in living organisms are known to cause various disorders, including metabolic, cardiovascular, hepatic, as well and neurodegenerative disorders. It affects body homeostasis as it destroys gut microbes. Conventional as well as present medicines are resolving the issues due to several side effects and heavy doses. The use of probiotics, prebiotics, and post-biotics (PPP) is limited to nutritional supplements but not considered as a medicine. There are several pieces of evidence that suggest that PPP can enhance the effect of various drugs. Probiotics are a series of beneficial microorganisms, and prebiotics are traditionally nondigestible food ingredients that selectively stimulate the growth and activity of a limited number of bacteria in the digestive tract. Recently, there has been an emerging trend to explore whether post-biotics (inanimate microorganisms and/or their components that confer a health benefit on the host) possess good biological activities for the prevention of disorders associated with ROS. Probiotics are beneficial microbes that cause the interaction of GIT tract with the nervous system, along with the immune system. Probiotics are reported to perform antioxidant activity along with anti-inflammatory, antibacterial, and immunomodulatory activity. Prebiotics are formed from saccharides and are capable of enhancing the growth of healthy bacteria in the human body. Post-biotics are usually released by the metabolic events and exert a beneficial effect on the host gut. Post-biotics can produce anti-inflammatory activity, anticancer activity, antioxidant activity, and even immunomodulatory action. This chapter will elaborate on the impact of prebiotics, probiotics, and post-biotics utilized for the therapeutic approach in restoring gut homeostasis.
