Human Mutant Dynactin Subunit 1 Causes Profound Motor Neuron Disease Consistent with Possible Mechanisms Involving Axonopathy, Mitochondriopathy, Protein Nitration, and T-Cell-Mediated Cytolysis Article

Xie, Victor, Franco, Maria Clara, Martin, Lee J. (2025). Human Mutant Dynactin Subunit 1 Causes Profound Motor Neuron Disease Consistent with Possible Mechanisms Involving Axonopathy, Mitochondriopathy, Protein Nitration, and T-Cell-Mediated Cytolysis . 15(12), 10.3390/biom15121637

Open Access

cited authors

  • Xie, Victor; Franco, Maria Clara; Martin, Lee J

sustainable development goals

authors

publication date

  • November 21, 2025

keywords

  • ALS
  • AMYOTROPHIC-LATERAL-SCLEROSIS
  • APOPTOSIS
  • Biochemistry & Molecular Biology
  • CD8
  • DEGENERATION
  • DNA-DAMAGE
  • Fas
  • G59S MUTATION
  • Life Sciences & Biomedicine
  • NITRIC-OXIDE
  • PERMEABILITY TRANSITION PORE
  • SINGLE-STRAND BREAKS
  • SUPEROXIDE-DISMUTASE
  • Science & Technology
  • T cell
  • TRANSGENIC MICE
  • cell death
  • heat-shock protein-90
  • mitochondria
  • motor neuron

Digital Object Identifier (DOI)

publisher

  • MDPI

volume

  • 15

issue

  • 12