Species differences in [11C]clorgyline binding in brain.
Other Scholarly Work
Fowler, JS, Ding, YS, Logan, J et al. (2001). Species differences in [11C]clorgyline binding in brain.
. Nuclear Medicine and Biology, 28(7), 779-785. 10.1016/s0969-8051(01)00245-1
Fowler, JS, Ding, YS, Logan, J et al. (2001). Species differences in [11C]clorgyline binding in brain.
. Nuclear Medicine and Biology, 28(7), 779-785. 10.1016/s0969-8051(01)00245-1
[11C]Clorgyline selectively binds to MAO A in the human brain. This contrasts with a recent report that [11C]clorgyline (in contrast to other labeled MAO A inhibitors) is not retained in the rhesus monkey brain [4]. To explore this difference, we compared [11C]clorgyline in the baboon brain before and after clorgyline pretreatment and we also synthesized deuterium substituted [11C]clorgyline (and its nor-precursor) for comparison. [11C]Clorgyline was not retained in the baboon brain nor was it influenced by clorgyline pretreatment or by deuterium substitution, contrasting to results in humans. This suggests a species difference in the susceptibility of MAO A to inhibition by clorgyline and represents an unusual example of where the behavior of a radiotracer in the baboon brain does not predict its behavior in the human brain.
