This chapter emphasizes the recent developments with the gas sensors based on two-dimensional (2D) MXene-based hybrid nanomaterials for the detection of various toxic gases. In the family of 2D materials, the new member, MXene has emerged as an outstanding gas sensing material due to its favorable characteristics like an abundance of interaction sites, metallic conductivity, tunable surface properties, bandgap, and excellent mechanical strength. Further, the ease of its solution processability and straightforward functionalization make it the choicest material for hybrids with different types of inorganic and organic nanomaterials. The synergic effect of MXene with these nanomaterials is found to enhance the response kinetics of the hybrid gas sensors. The synthesis of MXene-based nanohybrids, gas sensing kinetics, and sensing mechanisms of hybrid sensors have been elucidated in this chapter.