Helium-oxygen spirometry in experimental cotton dust exposure Article

Sepulveda, MJ, Hankinson, JL, Castellan, RM et al. (1984). Helium-oxygen spirometry in experimental cotton dust exposure . LUNG, 162(1), 347-356. 10.1007/BF02715667

cited authors

  • Sepulveda, MJ; Hankinson, JL; Castellan, RM; Cocke, JB

authors

abstract

  • Acute lung function responses to cotton dust were examined in 50 healthy adult volunteers known to respond acutely to cotton dust inhalation. Pre- and post-exposure air and helium-oxygen spirometry and specific airways conductance were employed for this purpose. Exposures were carefully controlled in a room ventilated with air from a model cardroom, lasted 6 h each, and were separated by 48 h intervals. Cotton dust exposure produced significant decrements in specific airways conductance (P<0.02), and in vital capacity, maximum expiratory flows breathing air (P<0.004) and on 80% helium-20% oxygen (HeO2) gas mixture (P<0.004). Cigarette smokers tended to have greater spirometric responses to cotton dust than nonsmokers, but differences between the groups were significant only for peak flow rate (PFR) andmax25 breathing HeO2 (P<0.05). Density dependence, defined as the mean HeO2:air ratio formax50 andmax25, was unaffected by cotton dust exposure. Changes in density dependence were not observed over shifts or between control and cotton dust exposures (P>0.05). This was true for the group as a whole as well as for the various smoking subgroups. The occurrence of central (SGAW, PFR, FEV1) and peripheral (max50,max25) airways narrowing among our subjects may explain the absence of a density dependence response to the levels of cotton dust used. Since only MEFV curves were employed, however, our ability to detect changes in density dependence may have been limited by the potential effect of the vital capacity maneuver on airways tone. © 1984 Springer-Verlag.

publication date

  • December 1, 1984

published in

Digital Object Identifier (DOI)

start page

  • 347

end page

  • 356

volume

  • 162

issue

  • 1