Pre-term birth (PTB) significantly impacts neonatal mortality and morbidity, causing developmental complications like neurological disorders. Our study used Mueller Matrix Imaging, alongside staining histological techniques, to investigate cervical remodeling during pregnancy. Cervical samples from pregnant mice at various gestational stages were analyzed, revealing detailed views of the extracellular matrix and cellular components. Complementary methods, including Hematoxylin and Eosin staining and a range of optical imaging techniques, were used to further explore tissue composition and vascular distribution. This multimodal approach offers a more comprehensive understanding of cervical remodeling, enhancing the ability to assess PTB risk and informing strategies to improve maternal and neonatal healthcare outcomes.
