Modulating the Mechanochemistry of Peptide-Polymer Hybrids for Precision Tissue Repair
Book Chapter
Spencer, P, Misra, A, Ye, Q et al. (2022). Modulating the Mechanochemistry of Peptide-Polymer Hybrids for Precision Tissue Repair
. 1-4 397-406. 10.1016/B978-0-12-820352-1.00208-X
Spencer, P, Misra, A, Ye, Q et al. (2022). Modulating the Mechanochemistry of Peptide-Polymer Hybrids for Precision Tissue Repair
. 1-4 397-406. 10.1016/B978-0-12-820352-1.00208-X
By 2030, the National Institutes of Health predicts that 72 million Americans will be 65 and older − and nearly 80% of them will suffer a chronic health condition that requires tissue, joint, or organ repair. Biomaterials will be key to meeting this demand. Biomaterials are used in millions of medical devices including implants, stents, catheters, and drug-delivery systems. These devices present a myriad of tissue-interaction issues and they can fail due to infection, material fouling, or rejection. Given the unprecedented demand for biomaterials and medical devices, alternative design solutions are critically needed. This urgent clinical need is the focus of research to develop “biologically-aware” materials — materials that respond to biological cues to simultaneously promote tissue repair and inhibit bacterial attachment. This article explores peptide-polymer hybrids as a model system for “biologically-aware” materials.
