Ring-Opening of Donor-Acceptor Cyclopropane Diester for the Synthesis of Oxime Esters and 2,3-Dihydroazete Ester
Article
Yadav, N, Verma, K, Das, A et al. (2024). Ring-Opening of Donor-Acceptor Cyclopropane Diester for the Synthesis of Oxime Esters and 2,3-Dihydroazete Ester
. SYNTHESIS-STUTTGART, 57(1), 91-98. 10.1055/a-2335-8566
Yadav, N, Verma, K, Das, A et al. (2024). Ring-Opening of Donor-Acceptor Cyclopropane Diester for the Synthesis of Oxime Esters and 2,3-Dihydroazete Ester
. SYNTHESIS-STUTTGART, 57(1), 91-98. 10.1055/a-2335-8566
A simple and efficient approach for the synthesis of privileged oxime esters by employing donor-acceptor cyclopropane diesters (DACs) as one of the potential precursors is reported. The strategy involves Lewis acid catalyzed ring-opening of DACs, resulting in an open-chain intermediate followed by the base-mediated construction of the corresponding oxime esters in a one-pot reaction. Moreover, the process also features the synthesis of diethyl 4-(4-methoxyphenyl)azete-2,2(3 H)-dicarboxylate.
