Structure/function studies of arsenite oxidoreductase and xanthine oxidase Article

Manikandan, P, Ellis, P, Kuhn, P et al. (2002). Structure/function studies of arsenite oxidoreductase and xanthine oxidase . Indian Journal of Chemistry - Section A Inorganic, Physical, Theoretical and Analytical Chemistry, 41(1), 22-31.

cited authors

  • Manikandan, P; Ellis, P; Kuhn, P; Choi, EY; Hoffman, B; Hille, R

abstract

  • The recently solved X-ray crystal structure of the molybdenum-containing arsenite oxidoreductase from Alcaligenes faecalis, is discussed, keeping in view the known mechanistic and spectroscopic information regarding the protein in a structural context. In addition, recent mechanistic studies of xanthine oxidase are covered, with the conclusion that the reaction mechanism is initiated by nucleophilic attack of a Mo-OH group on substrate.

authors

publication date

  • January 1, 2002

published in

start page

  • 22

end page

  • 31

volume

  • 41

issue

  • 1