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Diagnosis of manganism and manganese neurotoxicity: A workshop report. Other Scholarly Work

Mattison, Donald R, Momoli, Franco, Alyanak, Cemil et al. (2024). Diagnosis of manganism and manganese neurotoxicity: A workshop report. . 4(2), 11. 10.3892/mi.2024.135

cited authors

  • Mattison, Donald R; Momoli, Franco; Alyanak, Cemil; Aschner, Michael; Baker, Marissa; Cashman, Neil; Dydak, Ulrike; Farhat, Nawal; Guilarte, Tomás R; Karyakina, Nataliya; Ramoju, Siva; Shilnikova, Natalia; Taba, Pille; Krewski, Daniel

authors

abstract

  • With declining exposures to manganese (Mn) in occupational settings, there is a need for more sensitive exposure assessments and clinical diagnostic criteria for manganism and Mn neurotoxicity. To address this issue, a workshop was held on November 12-13, 2020, with international experts on Mn toxicity. The workshop discussions focused on the history of the diagnostic criteria for manganism, including those developed by the Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail (IRSST) in Quebec in 2005 and criteria developed by the Chinese government in 2002 and updated in 2006; the utility of biomarkers of exposure; recent developments in magnetic resonance imaging (MRI) for assessing Mn accumulation in the brain and diagnosing manganism; and potential future applications of metabolomics. The suggestions of the participants for updating manganism diagnostic criteria included the consideration of: i) A history of previous occupational and environmental exposure to Mn; ii) relevant clinical symptoms such as dystonia; iii) MRI imaging to document Mn accumulation in the neural tissues, including the basal ganglia; and iv) criteria for the differential diagnosis of manganism and other neurological conditions. Important research gaps include the characterization of Mn exposure and other co-exposures, exploration of the roles of different brain regions with MRI, understanding the complexity of metal ion transporters involved in Mn homeostasis, and a need for information on other neurotransmitter systems and brain regions underlying the pathophysiology of manganism.

publication date

  • March 1, 2024

Digital Object Identifier (DOI)

Medium

  • Electronic-eCollection

start page

  • 11

volume

  • 4

issue

  • 2