A genomic mutational constraint map using variation in 76,156 human genomes Article

Chen, Siwei, Francioli, Laurent C, Goodrich, Julia K et al. (2024). A genomic mutational constraint map using variation in 76,156 human genomes . NATURE, 625(7993), 10.1038/s41586-023-06045-0

International Collaboration

cited authors

  • Chen, Siwei; Francioli, Laurent C; Goodrich, Julia K; Collins, Ryan L; Kanai, Masahiro; Wang, Qingbo; Alfoldi, Jessica; Watts, Nicholas A; Vittal, Christopher; Gauthier, Laura D; Poterba, Timothy; Wilson, Michael W; Tarasova, Yekaterina; Phu, William; Grant, Riley; Yohannes, Mary T; Koenig, Zan; Farjoun, Yossi; Banks, Eric; Donnelly, Stacey; Gabriel, Stacey; Gupta, Namrata; Ferriera, Steven; Tolonen, Charlotte; Novod, Sam; Bergelson, Louis; Roazen, David; Ruano-Rubio, Valentin; Covarrubias, Miguel; Llanwarne, Christopher; Petrillo, Nikelle; Wade, Gordon; Jeandet, Thibault; Munshi, Ruchi; Tibbetts, Kathleen; O'Donnell-Luria, Anne; Solomonson, Matthew; Seed, Cotton; Martin, Alicia R; Talkowski, Michael E; Rehm, Heidi L; Daly, Mark J; Tiao, Grace; Neale, Benjamin M; MacArthur, Daniel G; Karczewski, Konrad J; Abreu, Maria; Aguilar Salinas, Carlos A; Ahmad, Tariq; Albert, Christine M; Alfoldi, Jessica; Ardissino, Diego; Armean, Irina M; Atkinson, Elizabeth G; Atzmon, Gil; Banks, Eric; Barnard, John; Baxter, Samantha M; Beaugerie, Laurent; Benjamin, Emelia J; Benjamin, David; Bergelson, Louis; Boehnke, Michael; Bonnycastle, Lori L; Bottinger, Erwin P; Bowden, Donald W; Bown, Matthew J; Brand, Harrison; Brant, Steven; Brookings, Ted; Bryant, Sam; Calvo, Sarah E; Campos, Hannia; Chambers, John C; Chan, Juliana C; Chao, Katherine R; Chapman, Sinead; Chasman, Daniel I; Chen, Siwei; Chisholm, Rex; Cho, Judy; Chowdhury, Rajiv; Chung, Mina K; Chung, Wendy K; Cibulskis, Kristian; Cohen, Bruce; Collins, Ryan L; Connolly, Kristen M; Correa, Adolfo; Covarrubias, Miguel; Cummings, Beryl B; Dabelea, Dana; Danesh, John; Darbar, Dawood; Darnowsky, Phil; Denny, Joshua; Donnelly, Stacey; Duggirala, Ravindranath; Dupuis, Josee; Ellinor, Patrick T; Elosua, Roberto; Emery, James; England, Eleina; Erdmann, Jeanette; Esko, Tonu; Evangelista, Emily; Farjoun, Yossi; Fatkin, Diane; Ferriera, Steven; Florez, Jose; Francioli, Laurent C; Franke, Andre; Fu, Jack; Farkkila, Martti; Gabriel, Stacey; Garimella, Kiran; Gauthier, Laura D; Gentry, Jeff; Getz, Gad; Glahn, David C; Glaser, Benjamin; Glatt, Stephen J; Goldstein, David; Gonzalez, Clicerio; Goodrich, Julia K; Grant, Riley; Groop, Leif; Gudmundsson, Sanna; Gupta, Namrata; Haessly, Andrea; Haiman, Christopher; Hall, Ira; Hanis, Craig L; Harms, Matthew; Hiltunen, Mikko; Holi, Matti M; Hultman, Christina M; Jalas, Chaim; Jeandet, Thibault; Kallela, Mikko; Kanai, Masahiro; Kaplan, Diane; Kaprio, Jaakko; Kathiresan, Sekar; Kenny, Eimear E; Kim, Bong-Jo; Kim, Young Jin; King, Daniel; Kirov, George; Koenig, Zan; Kooner, Jaspal; Koskinen, Seppo; Krumholz, Harlan M; Kugathasan, Subra; Kwak, Soo Heon; Laakso, Markku; Lake, Nicole; Langsford, Trevyn; Laricchia, Kristen M; Lehtimaki, Terho; Lek, Monkol; Lipscomb, Emily; Llanwarne, Christopher; Loos, Ruth JF; Lu, Wenhan; Lubitz, Steven A; Tusie Luna, Teresa; Ma, Ronald CW; Marcus, Gregory M; Marrugat, Jaume; Mattila, Kari M; McCarroll, Steven; McCarthy, Mark I; McCauley, Jacob L; McGovern, Dermot; McPherson, Ruth; Meigs, James B; Melander, Olle; Metspalu, Andres; Meyers, Deborah; Minikel, Eric V; Mitchell, Braxton D; Mootha, Vamsi K; Munshi, Ruchi; Naheed, Aliya; Nazarian, Saman; Nilsson, Peter M; Novod, Sam; O'Donnell-Luria, Anne; O'Donovan, Michael C; Okada, Yukinori; Ongur, Dost; Orozco, Lorena; Owen, Michael J; Palmer, Colin; Palmer, Nicholette D; Palotie, Aarno; Park, Kyong Soo; Pato, Carlos; Petrillo, Nikelle; Phu, William; Poterba, Timothy; Pulver, Ann E; Rader, Dan; Rahman, Nazneen; Reiner, Alex; Remes, Anne M; Rhodes, Dan; Rich, Stephen; Rioux, John D; Ripatti, Samuli; Roazen, David; Roden, Dan M; Rotter, Jerome I; Ruano-Rubio, Valentin; Sahakian, Nareh; Saleheen, Danish; Salomaa, Veikko; Saltzman, Andrea; Samani, Nilesh J; Samocha, Kaitlin E; Sanchis-Juan, Alba; Scharf, Jeremiah; Schleicher, Molly; Schunkert, Heribert; Schoenherr, Sebastian; Seaby, Eleanor G; Shah, Svati H; Shand, Megan; Sharpe, Ted; Shoemaker, Moore B; Shyong, Tai; Silverman, Edwin K; Singer-Berk, Moriel; Sklar, Pamela; Smith, Jonathan T; Smith, J Gustav; Soininen, Hilkka; Sokol, Harry; Son, Rachel G; Soto, Jose; Spector, Tim; Stevens, Christine; Stitziel, Nathan O; Sullivan, Patrick F; Suvisaari, Jaana; Tai, E Shyong; Tarasova, Yekaterina; Taylor, Kent D; Teo, Yik Ying; Tibbetts, Kathleen; Tolonen, Charlotte; Tsuang, Ming; Tuomi, Tiinamaija; Turner, Dan; Tusie-Luna, Teresa; Vartiainen, Erkki; Vawter, Marquis; Vittal, Christopher; Wade, Gordon; Wang, Lily; Wang, Qingbo; Wang, Arcturus; Ware, James S; Watkins, Hugh; Watts, Nicholas A; Weersma, Rinse K; Weisburd, Ben; Wessman, Maija; Whiffin, Nicola; Wilson, Michael W; Wilson, James G; Xavier, Ramnik J; Yohannes, Mary T

sustainable development goals

authors

publication date

  • January 4, 2024

published in

keywords

  • ANNOTATION
  • ASCL2
  • DOMINANCE ANALYSIS
  • EXPRESSION
  • GENES
  • IDENTIFICATION
  • Multidisciplinary Sciences
  • PLASMINOGEN
  • PREDICTORS
  • REGULATORY ELEMENTS
  • Science & Technology
  • Science & Technology - Other Topics
  • VARIANTS

Digital Object Identifier (DOI)

publisher

  • NATURE PORTFOLIO

volume

  • 625

issue

  • 7993