A microfluidic array of primary mammalian hepatocytes for use in high-throughput drug screening Conference

Kane, BJ, Zinner, MJ, Yarmush, ML et al. (2005). A microfluidic array of primary mammalian hepatocytes for use in high-throughput drug screening . 1 421-423.

cited authors

  • Kane, BJ; Zinner, MJ; Yarmush, ML; Toner, M

authors

abstract

  • Nearly half a billion dollars in resources are lost each time a drug candidate is withdrawn from the market by the Food and Drug Administration (FDA). The number of late-phase drug developmental failures due to liver toxicity could potentially be reduced through the use of hepatocyte-based systems capable of modelling the response of in vivo liver tissue to toxic insults. Here we report the development of a 64 (8×8) element array of microfluidic wells capable of supporting micropatterned primary rat hepatocytes in co-culture with 3T3-J2 fibroblasts. Copyright © 2005 by the Transducer Research Foundation, Inc.

publication date

  • January 1, 2005

start page

  • 421

end page

  • 423

volume

  • 1