Computational Analysis of a Light-Weight SUVr Processing Technique for Neuroimaging Alzheimer's Disease Conference

Mayrand, RP, Freytes, CY, Sawada, LO et al. (2022). Computational Analysis of a Light-Weight SUVr Processing Technique for Neuroimaging Alzheimer's Disease . 1787-1791. 10.1109/CSCI58124.2022.00317

cited authors

  • Mayrand, RP; Freytes, CY; Sawada, LO; Adeyosoye, M; Cid, REC; Lowenstein, D; Duara, R; Adjouadi, M

authors

abstract

  • The Standard Uptake Value (SUV) is conventionally calculated using the ratio of the injected PET radiotracer dose and subject body weight (Binj). SUVs are used to obtain SUV ratios (SUVr), an important metric in many Alzheimer's Disease (AD) neuroimaging studies. However, SUVr can be obtained using only neuroimaging data, bypassing the need for Bin. This paper proposes the SUVr-LightWeight (SUVr-LW) algorithm which is not reliant on clinical data and instead focuses on PET intensity values. The SUVr-LW was evaluated using the Centiloid Project Florebetaben (FBB) subject cohort and reached a linear regression slope of 0.98, while the healthy control subjects produced a slope of 0.87.

publication date

  • January 1, 2022

Digital Object Identifier (DOI)

International Standard Book Number (ISBN) 13

start page

  • 1787

end page

  • 1791