Effect of 4000 IU Vitamin D3 Supplements on Advanced Glycation End Products (AGEs) Among Adults with Type 2 Diabetes and Hypovitaminosis D
Other Scholarly Work
Owusu, Justina, Huffman, Fatma, Liuzzi, Juan et al. (2020). Effect of 4000 IU Vitamin D3 Supplements on Advanced Glycation End Products (AGEs) Among Adults with Type 2 Diabetes and Hypovitaminosis D
. 4(Suppl 2), 1829-1829.
Owusu, Justina, Huffman, Fatma, Liuzzi, Juan et al. (2020). Effect of 4000 IU Vitamin D3 Supplements on Advanced Glycation End Products (AGEs) Among Adults with Type 2 Diabetes and Hypovitaminosis D
. 4(Suppl 2), 1829-1829.
Diabetes related complications include kidney, eye, heart diseases and amputations. Advanced Glycation End Products, (AGEs) are biomarkers of T2D. AGEs are covalent adducts formed from reactions between sugars and proteins or lipids. Vitamin D deficiency, prevalent with T2D, increases oxidative stress and inflammation that promotes the formation of AGEs. This study assessed the effect of 4000 IU vitamin D supplements on AGEs in adults with T2D and vitamin D deficiency/insufficiency.
Methods
We assessed changes in serum AGEs of 41 African Americans and Hispanics with T2D and hypovitaminosis D who were supplemented with 4000 IU of vitamin D3 for 6 months. Total AGEs were assessed using commercially available kits (Biotang Inc/TSZ Elisa, Waltham, MA, USA).
Results
The mean age of study participants was 54 ± 8 years. AGEs significantly increased at 3 months compared to baseline (Mean Difference = −13.70 ng/ml, P = 0.007). The mean level of AGEs decreased significantly at 6 months of supplementation (Mean Difference = 9.79 ng/ml, P = 0.020). Additionally, the mean serum levels of AGEs were significantly higher at 3 months compared to 6 months among study participants (Mean Difference = 24.52 ng/ml, P < 0.0001).
Conclusions
Daily supplementation of 4000 IU vitamin D3 reduced AGEs at 6 months but not at 3 months. Supplementation of this minority population with vitamin D may delay the accumulation of AGEs and complications related to T2D.
Funding Sources
Funding for this research was provided through an NIH/NIDDK sponsored grant.
