Towards immunoproteasome-specific inhibitors: An improved synthesis of dihydroeponemycin Article

Ho, A, Cyrus, K, Kim, KB. (2005). Towards immunoproteasome-specific inhibitors: An improved synthesis of dihydroeponemycin . European Journal of Organic Chemistry, (22), 4829-4834. 10.1002/ejoc.200500437

cited authors

  • Ho, A; Cyrus, K; Kim, KB

abstract

  • Eponemycin, an antitumor and antiangiogenic epoxy ketone natural product, is previously shown to target proteasome for its activity. Although there have been many synthetic approaches developed, practical and efficient synthetic strategy for eponemycin has yet to be accomplished. Here, we report an efficient new route for the preparation of dihydroeponemycin, an active eponemycin derivative. This will aid the design of proteasome inhibitors with novel activity. © Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

authors

publication date

  • November 11, 2005

published in

Digital Object Identifier (DOI)

start page

  • 4829

end page

  • 4834

issue

  • 22