The ubiquitin-proteasome pathway and proteasome inhibitors Review

Myung, J, Kim, KB, Crews, CM. (2001). The ubiquitin-proteasome pathway and proteasome inhibitors . Medicinal Research Reviews, 21(4), 245-273. 10.1002/med.1009

cited authors

  • Myung, J; Kim, KB; Crews, CM

abstract

  • The ubiquitin-proteasome pathway has emerged as a central player in the regulation of several diverse cellular processes. Here, we describe the important components of this complex biochemical machinery as well as several important cellular substrates targeted by this pathway and examples of human diseases resulting from defects in various components of the ubiquitin-proteasome pathway. In addition, this review covers the chemistry of synthetic and natural proteasome inhibitors, emphasizing their mode of actions toward the 20S proteasome. Given the importance of proteasome-mediated protein degradation in various intracellular processes, inhibitors of this pathway will continue to serve as both molecular probes of major cellular networks as well as potential therapeutic agents for various human diseases. © 2001 John Wiley & Sons, Inc.

authors

publication date

  • July 4, 2001

published in

Digital Object Identifier (DOI)

start page

  • 245

end page

  • 273

volume

  • 21

issue

  • 4