Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration Article

Rayala, Ramanjaneyulu, Tiller, Annika, Majumder, Shahayra AA et al. (2023). Solid-Phase Synthesis of the Bicyclic Peptide OL-CTOP Containing Two Disulfide Bridges, and an Assessment of Its In Vivo μ-Opioid Receptor Antagonism after Nasal Administration . 28(4), 10.3390/molecules28041822

Open Access

cited authors

  • Rayala, Ramanjaneyulu; Tiller, Annika; Majumder, Shahayra AA; Stacy, Heather MM; Eans, Shainnel OO; Nedovic, Aleksandra; McLaughlin, Jay PP; Cudic, Predrag

sustainable development goals

authors

publication date

  • February 1, 2023

keywords

  • BOND FORMATION
  • Biochemistry & Molecular Biology
  • CTOP
  • CYSTEINE
  • Chemistry
  • Chemistry, Multidisciplinary
  • DESIGN
  • DOPAMINE
  • DRUG
  • IODINE OXIDATION
  • Life Sciences & Biomedicine
  • Physical Sciences
  • SELECTIVE PEPTIDE
  • SIDE REACTION
  • STABILITY
  • STRATEGIES
  • Science & Technology
  • antagonism
  • disulfide bond
  • intranasal delivery
  • morphine
  • mu-opioid receptor
  • odorranalectin
  • respiratory depression
  • solid-phase synthesis
  • trypsin

Digital Object Identifier (DOI)

publisher

  • MDPI

volume

  • 28

issue

  • 4