Development and validation of simultaneous equation method for determination of metoprolol and amlodipine in combined dosage form Article

Chaudhary, J, Jain, A, Kaur, N et al. (2012). Development and validation of simultaneous equation method for determination of metoprolol and amlodipine in combined dosage form . 4(SUPPL.3), 191-194.

cited authors

  • Chaudhary, J; Jain, A; Kaur, N; Saini, V

authors

abstract

  • A simple, rapid, precise, accurate and economical spectrophotometric method requiring no prior separation has been developed for the simultaneous estimation of amlodipine and metoprolol in tablet dosage form. Amlodipine and Metoprolol exhibit absorption maxima at 237.5 and 223 nm respectively. The developed Simultaneous equation method obeyed Beer's Law in the concentration range of 5-25 μg/ml for both the drugs. The proposed method is recommended for routine analysis of amlodipine and metoprolol as it is rapid, precise, accurate and reproducible. The results of the tablet analysis were validated with respect to recovery (accuracy), linearity, limit of detection and limit of quantization according to ICH guidelines and found to be satisfactory.

publication date

  • June 26, 2012

start page

  • 191

end page

  • 194

volume

  • 4

issue

  • SUPPL.3