Kinetic spectrophotometric method for the estimation of Ofloxacin in pharmaceutical formulations Article

Kishore, L, Kumar, A, Nair, A et al. (2012). Kinetic spectrophotometric method for the estimation of Ofloxacin in pharmaceutical formulations . 56(4), 355-361.

cited authors

  • Kishore, L; Kumar, A; Nair, A; Kaur, N

authors

abstract

  • The objective of the current study was to develop a direct, sensitive spectrophotometric method based on the oxidation of Ofloxacin using potassium permanganate in alkaline medium. The rate of change of absorbance was measured at 603 nm. The initial rate method and fixed time method (at 4 min) are utilised to construct calibration graphs for calculating the concentration of the drug. The results were validated through inter day and intraday precision assays according to the ICH guidelines and also through recovery studies. Statistical comparison of the proposed methods with that of reference method shows excellent agreement and indicates no significant difference in their accuracy and precision. © 2012, Sociedad Química de México.

publication date

  • December 1, 2012

start page

  • 355

end page

  • 361

volume

  • 56

issue

  • 4