The objective of this study was to investigate the anti-inflammatory and analgesic activity of curcumin with combination of different drugs using carrageenan induced paw edema model and writhing test in mice. Nimesulide and tenoxicam were administered orally at different doses of 2.5, 5.0 and 7.5 mg/kg and the lower doses of these drugs were also administered orally with curcumin 60 mg/kg. After, 1 hour 0.1 ml of carrageenan (i.e. 10 mg/ml) was injected into the sub-plantar region of right hind paw of the Wistar Albino rats (150-200g) and paw volume was measured after 30 mins 1 hr, 2 hr and 3 hr using a Plethysmometer. In analgesic activity, the drug ketorolac was used with combination of curcumin and number of writhes induced by glacial acetic acid administration in mice were observed. Administration of carrageenan produced significant edema in the hind paw of rats. The edema was found to be significantly inhibited by combination of curcumin 60 mg/kg and the lower doses of nimesulide & tenoxicam in different time interval and having comparable effects as of higher doses of these drugs. Similar results were also observed in analgesic activity. From this study it can be concluded that curcumin having synergistic effect when administered with combination different anti-inflammatory and analgesic agents.