Pullulan in biomedical research and development - A review Article

Singh, RS, Kaur, N, Hassan, M et al. (2021). Pullulan in biomedical research and development - A review . INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 166 694-706. 10.1016/j.ijbiomac.2020.10.227

cited authors

  • Singh, RS; Kaur, N; Hassan, M; Kennedy, JF

authors

abstract

  • Pullulan is an imperative microbial exo-polymer commercially produced by yeast like fungus Aureobasidium pullulans. Its structure contains maltosyl repeating units which comprises two α-(1 → 4) linked glucopyranose rings attached to one glucopyranose ring through α-(1 → 6) glycosidic bond. The co-existence of α-(1 → 6) and α-(1 → 4) glycosidic linkages endows distinctive physico-chemical properties to pullulan. It is highly biocompatible, non-toxic and non-carcinogenic in nature. It is extremely resistant to any mutagenicity or immunogenicity. The unique properties of pullulan make it a potent candidate for biomedical applications viz. drug delivery, gene delivery, tissue engineering, molecular chaperon, plasma expander, vaccination, etc. This review highlights the potential of pullulan in biomedical research and development.

publication date

  • January 1, 2021

published in

Digital Object Identifier (DOI)

start page

  • 694

end page

  • 706

volume

  • 166