We consider a stochastic 2D liquid crystal model with a multiplicative noise of Lévy type, which models the dynamic of nematic liquid crystals under the influence of stochastic external forces of jump type. We derive a large deviation principle for the model. The proof is based on the weak convergence method introduced in [Budhiraja A, Dupuis P, Maroulas V. Variational representations for continuous time processes. Ann Inst Henri Poincar Probab Stat. 2011;47(3):725–747].