The pleiotropic role of galectin-3 in melanoma progression: Unraveling the enigma Article

Mohammed, NBB, Antonopoulos, A, Dell, A et al. (2023). The pleiotropic role of galectin-3 in melanoma progression: Unraveling the enigma . 157 157-193. 10.1016/bs.acr.2022.06.001

cited authors

  • Mohammed, NBB; Antonopoulos, A; Dell, A; Haslam, SM; Dimitroff, CJ

abstract

  • Melanoma is a highly aggressive skin cancer with poor outcomes associated with distant metastasis. Intrinsic properties of melanoma cells alongside the crosstalk between melanoma cells and surrounding microenvironment determine the tumor behavior. Galectin-3 (Gal-3), a ß-galactoside-binding lectin, has emerged as a major effector in cancer progression, including melanoma behavior. Data from melanoma models and patient studies reveal that Gal-3 expression is dysregulated, both intracellularly and extracellularly, throughout the stages of melanoma progression. This review summarizes the most recent data and hypotheses on Gal-3 and its tumor-modulating functions, highlighting its role in driving melanoma growth, invasion, and metastatic colonization. It also provides insight into potential Gal-3-targeted strategies for melanoma diagnosis and treatment.

publication date

  • January 1, 2023

Digital Object Identifier (DOI)

start page

  • 157

end page

  • 193

volume

  • 157