Communication - Cucurbituril Mediated Electronic Identification of Single Nucleobases Article

Xiao, B, Li, Y, Chang, S. (2022). Communication - Cucurbituril Mediated Electronic Identification of Single Nucleobases . JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 169(5), 10.1149/1945-7111/ac700a

cited authors

  • Xiao, B; Li, Y; Chang, S

authors

abstract

  • Electronically detecting and identifying four DNA nucleosides offers great opportunity in DNA sequencing. By introducing a cage-shaped molecule cucurbit[7]uril (CB[7]) into the tunneling junction to capture nucleobases, we show that all four DNA nucleobases can be better detected and identified, in contrast to the results measured with bare electrodes, and a conductivity order of T < A ∼C < G can be clearly revealed with a correct single base read up to 84% from each individual tunneling signal. This work provides a unique electronic approach in identifying single DNA bases and paves the way for the realization of high-precision DNA single-molecule analysis using tunneling current.

publication date

  • May 1, 2022

published in

Digital Object Identifier (DOI)

volume

  • 169

issue

  • 5